Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy
Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and...
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| Veröffentlicht in: | Nanoscale 2016-03, Vol.8 (12), p.649-6494 |
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| container_title | Nanoscale |
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| creator | Broekgaarden, M van Vught, R Oliveira, S Roovers, R. C van Bergen en Henegouwen, P. M. P Pieters, R. J Van Gulik, T. M Breukink, E Heger, M |
| description | Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.
An immunotargeted drug delivery system for hydrophobic photosensitizers was developed for application in photodynamic therapy of solid tumors. |
| doi_str_mv | 10.1039/c6nr00014b |
| format | Article |
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An immunotargeted drug delivery system for hydrophobic photosensitizers was developed for application in photodynamic therapy of solid tumors.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Cell Line, Tumor</subject><subject>Conjugation</subject><subject>Drug Carriers</subject><subject>Effectiveness</subject><subject>Humans</subject><subject>Indoles - chemistry</subject><subject>Kinetics</subject><subject>Liposomes</subject><subject>Liposomes - chemistry</subject><subject>Mice</subject><subject>Nanomedicine - methods</subject><subject>Organometallic Compounds - chemistry</subject><subject>Oxygen - chemistry</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - administration & dosage</subject><subject>Single-Domain Antibodies - chemistry</subject><subject>Strategy</subject><subject>Uptakes</subject><subject>Zinc</subject><subject>Zinc - chemistry</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1PHDEQxS0UlIMjDX0ilxHSgr32fpXhFD4kBFIC9cprj-982bU3trc4av5wDHc5ylTzRu83b4qH0Ckl55Sw5kKW1hNCKO8O0FFOOMkYq_JPe13yGToOYU1I2bCSfUazvGwKXtDiCL38NhGyMII02kgsnV1PSxGNs9hpHIxd9oCVG4SxWNhoOqcMBBwd7s3oghvSAnYlrExiXLnoAthgonkGj6cxij-Q7tTWUhsrhvQlrsCLcYNBp59Cbk7QoRZ9gC-7OUdPVz8fFzfZ3cP17eLHXSY5bWKWc6E1Z41QIHOo6k5AXnFVUmBQQ62gEKzmSmnQkgpoKC9yXahOVkqlAMXm6Ps2d_Tu7wQhtoMJEvpeWHBTaGlNCG8o4-T_aFXxghGS6Dk626LSuxA86Hb0ZhB-01LSvhXULsr7X-8FXSb42y536gZQe_RfIwn4ugV8kHv3o2H2CqBkmdE</recordid><startdate>20160328</startdate><enddate>20160328</enddate><creator>Broekgaarden, M</creator><creator>van Vught, R</creator><creator>Oliveira, S</creator><creator>Roovers, R. 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| fulltext | fulltext |
| identifier | ISSN: 2040-3364 |
| ispartof | Nanoscale, 2016-03, Vol.8 (12), p.649-6494 |
| issn | 2040-3364 2040-3372 |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Animals Antibodies Cell Line, Tumor Conjugation Drug Carriers Effectiveness Humans Indoles - chemistry Kinetics Liposomes Liposomes - chemistry Mice Nanomedicine - methods Organometallic Compounds - chemistry Oxygen - chemistry Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Single-Domain Antibodies - chemistry Strategy Uptakes Zinc Zinc - chemistry |
| title | Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy |
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