Activation of cytomegalovirus-specific CD8+ T-cell response by antibody-mediated peptide-major histocompatibility class I complexes

Imposing antigenicity on tumor cells is a key step toward successful cancer-immunotherapy. A cytomegalovirus-derived peptide recombinantly fused to a major histocompatibility class I complex and a monoclonal antibody can be targeted to tumor cells by antibody-mediated delivery and activate a strong...

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Veröffentlicht in:	Oncoimmunology 2016-01, Vol.5 (1), p.e1052930-e1052930
Hauptverfasser:	Schmittnaegel, Martina, Klein, Christian, Levitsky, Victor, Knoetgen, Hendrik
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody fusion Author's View CMV-pp65-specific CD8+ T cells major histocompatibility class I MHCI restricted T-cell activation targeted T-cell recruiter viral mimicry on cancer cells
Online-Zugang:	Volltext
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