Antibody Production in Plants and Green Algae
Monoclonal antibodies (mAbs) have a wide range of modern applications, including research, diagnostic, therapeutic, and industrial uses. Market demand for mAbs is high and continues to grow. Although mammalian systems, which currently dominate the biomanufacturing industry, produce effective and saf...
Gespeichert in:
| Veröffentlicht in: | Annual review of plant biology 2016-04, Vol.67 (1), p.669-701 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 701 |
|---|---|
| container_issue | 1 |
| container_start_page | 669 |
| container_title | Annual review of plant biology |
| container_volume | 67 |
| creator | Yusibov, Vidadi Kushnir, Natasha Streatfield, Stephen J |
| description | Monoclonal antibodies (mAbs) have a wide range of modern applications, including research, diagnostic, therapeutic, and industrial uses. Market demand for mAbs is high and continues to grow. Although mammalian systems, which currently dominate the biomanufacturing industry, produce effective and safe recombinant mAbs, they have a limited manufacturing capacity and high costs. Bacteria, yeast, and insect cell systems are highly scalable and cost effective but vary in their ability to produce appropriate posttranslationally modified mAbs. Plants and green algae are emerging as promising production platforms because of their time and cost efficiencies, scalability, lack of mammalian pathogens, and eukaryotic posttranslational protein modification machinery. So far, plant- and algae-derived mAbs have been produced predominantly as candidate therapeutics for infectious diseases and cancer. These candidates have been extensively evaluated in animal models, and some have shown efficacy in clinical trials. Here, we review ongoing efforts to advance the production of mAbs in plants and algae. |
| doi_str_mv | 10.1146/annurev-arplant-043015-111812 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_26905655</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808706474</sourcerecordid><originalsourceid>FETCH-LOGICAL-a500t-1808cb18b237bef6a87df423afdde7a04cfa7e8abc31052b377ca41c6691facb3</originalsourceid><addsrcrecordid>eNqVkctKxDAUhoMo3l9BCiK4iebkPgsX4-ANBGeh65CmqVQ66Zi0im9vxo4u3IirZPGd_8_Jh9AJkDMALs9tCEP0b9jGZWtDjwlnBAQGAA10A-2C4AJToGzz686wIETvoL2UXkgGOYVttEPlhAgpxC7C09A3ZVd9FPPYVYPrmy4UTSjmq_BU2FAVN9H7UEzbZ-sP0FZt2-QP1-c-erq-epzd4vuHm7vZ9B7b3NZj0ES7EnRJmSp9La1WVc0ps3VVeWUJd7VVXtvSMSCClkwpZzk4KSdQW1eyfXQ65i5j9zr41JtFk5xv86N8NySzKlBEcsX_RpUWSrCJJBk9_oW-dEMMeZFMTWhmpNSZuhgpF7uUoq_NMjYLGz8MELNSYNYKzFqBGRWYUUGeP1q3DOXCVz_T33-egcsRWOXYNic1_j39s-UTgAucSQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1792396668</pqid></control><display><type>article</type><title>Antibody Production in Plants and Green Algae</title><source>Annual Reviews</source><source>MEDLINE</source><creator>Yusibov, Vidadi ; Kushnir, Natasha ; Streatfield, Stephen J</creator><creatorcontrib>Yusibov, Vidadi ; Kushnir, Natasha ; Streatfield, Stephen J</creatorcontrib><description>Monoclonal antibodies (mAbs) have a wide range of modern applications, including research, diagnostic, therapeutic, and industrial uses. Market demand for mAbs is high and continues to grow. Although mammalian systems, which currently dominate the biomanufacturing industry, produce effective and safe recombinant mAbs, they have a limited manufacturing capacity and high costs. Bacteria, yeast, and insect cell systems are highly scalable and cost effective but vary in their ability to produce appropriate posttranslationally modified mAbs. Plants and green algae are emerging as promising production platforms because of their time and cost efficiencies, scalability, lack of mammalian pathogens, and eukaryotic posttranslational protein modification machinery. So far, plant- and algae-derived mAbs have been produced predominantly as candidate therapeutics for infectious diseases and cancer. These candidates have been extensively evaluated in animal models, and some have shown efficacy in clinical trials. Here, we review ongoing efforts to advance the production of mAbs in plants and algae.</description><identifier>ISSN: 1543-5008</identifier><identifier>EISSN: 1545-2123</identifier><identifier>DOI: 10.1146/annurev-arplant-043015-111812</identifier><identifier>PMID: 26905655</identifier><language>eng</language><publisher>United States: Annual Reviews</publisher><subject>Algae ; algae production ; Animal models ; Animals ; Antibodies, Monoclonal - biosynthesis ; Antibodies, Monoclonal - genetics ; Antibodies, Monoclonal - metabolism ; Antibody Formation ; Aquatic plants ; Bacteria ; Chlorophyta - genetics ; Chlorophyta - metabolism ; Genetic Engineering ; glycoengineering ; Infectious diseases ; Mammals ; Monoclonal antibodies ; monoclonal antibody ; Plant biology ; plant production ; Plants - genetics ; Plants - metabolism ; Plants, Genetically Modified ; Proteins ; Recombinant Proteins - biosynthesis ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; transgenic ; transient expression ; transplastomic ; Yeasts</subject><ispartof>Annual review of plant biology, 2016-04, Vol.67 (1), p.669-701</ispartof><rights>Copyright © 2016 by Annual Reviews. All rights reserved 2016</rights><rights>Copyright Annual Reviews, Inc. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a500t-1808cb18b237bef6a87df423afdde7a04cfa7e8abc31052b377ca41c6691facb3</citedby><cites>FETCH-LOGICAL-a500t-1808cb18b237bef6a87df423afdde7a04cfa7e8abc31052b377ca41c6691facb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-arplant-043015-111812?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-arplant-043015-111812$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,780,784,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26905655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yusibov, Vidadi</creatorcontrib><creatorcontrib>Kushnir, Natasha</creatorcontrib><creatorcontrib>Streatfield, Stephen J</creatorcontrib><title>Antibody Production in Plants and Green Algae</title><title>Annual review of plant biology</title><addtitle>Annu Rev Plant Biol</addtitle><description>Monoclonal antibodies (mAbs) have a wide range of modern applications, including research, diagnostic, therapeutic, and industrial uses. Market demand for mAbs is high and continues to grow. Although mammalian systems, which currently dominate the biomanufacturing industry, produce effective and safe recombinant mAbs, they have a limited manufacturing capacity and high costs. Bacteria, yeast, and insect cell systems are highly scalable and cost effective but vary in their ability to produce appropriate posttranslationally modified mAbs. Plants and green algae are emerging as promising production platforms because of their time and cost efficiencies, scalability, lack of mammalian pathogens, and eukaryotic posttranslational protein modification machinery. So far, plant- and algae-derived mAbs have been produced predominantly as candidate therapeutics for infectious diseases and cancer. These candidates have been extensively evaluated in animal models, and some have shown efficacy in clinical trials. Here, we review ongoing efforts to advance the production of mAbs in plants and algae.</description><subject>Algae</subject><subject>algae production</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - biosynthesis</subject><subject>Antibodies, Monoclonal - genetics</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Antibody Formation</subject><subject>Aquatic plants</subject><subject>Bacteria</subject><subject>Chlorophyta - genetics</subject><subject>Chlorophyta - metabolism</subject><subject>Genetic Engineering</subject><subject>glycoengineering</subject><subject>Infectious diseases</subject><subject>Mammals</subject><subject>Monoclonal antibodies</subject><subject>monoclonal antibody</subject><subject>Plant biology</subject><subject>plant production</subject><subject>Plants - genetics</subject><subject>Plants - metabolism</subject><subject>Plants, Genetically Modified</subject><subject>Proteins</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - metabolism</subject><subject>transgenic</subject><subject>transient expression</subject><subject>transplastomic</subject><subject>Yeasts</subject><issn>1543-5008</issn><issn>1545-2123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkctKxDAUhoMo3l9BCiK4iebkPgsX4-ANBGeh65CmqVQ66Zi0im9vxo4u3IirZPGd_8_Jh9AJkDMALs9tCEP0b9jGZWtDjwlnBAQGAA10A-2C4AJToGzz686wIETvoL2UXkgGOYVttEPlhAgpxC7C09A3ZVd9FPPYVYPrmy4UTSjmq_BU2FAVN9H7UEzbZ-sP0FZt2-QP1-c-erq-epzd4vuHm7vZ9B7b3NZj0ES7EnRJmSp9La1WVc0ps3VVeWUJd7VVXtvSMSCClkwpZzk4KSdQW1eyfXQ65i5j9zr41JtFk5xv86N8NySzKlBEcsX_RpUWSrCJJBk9_oW-dEMMeZFMTWhmpNSZuhgpF7uUoq_NMjYLGz8MELNSYNYKzFqBGRWYUUGeP1q3DOXCVz_T33-egcsRWOXYNic1_j39s-UTgAucSQ</recordid><startdate>20160429</startdate><enddate>20160429</enddate><creator>Yusibov, Vidadi</creator><creator>Kushnir, Natasha</creator><creator>Streatfield, Stephen J</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>M7N</scope></search><sort><creationdate>20160429</creationdate><title>Antibody Production in Plants and Green Algae</title><author>Yusibov, Vidadi ; Kushnir, Natasha ; Streatfield, Stephen J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a500t-1808cb18b237bef6a87df423afdde7a04cfa7e8abc31052b377ca41c6691facb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Algae</topic><topic>algae production</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - biosynthesis</topic><topic>Antibodies, Monoclonal - genetics</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>Antibody Formation</topic><topic>Aquatic plants</topic><topic>Bacteria</topic><topic>Chlorophyta - genetics</topic><topic>Chlorophyta - metabolism</topic><topic>Genetic Engineering</topic><topic>glycoengineering</topic><topic>Infectious diseases</topic><topic>Mammals</topic><topic>Monoclonal antibodies</topic><topic>monoclonal antibody</topic><topic>Plant biology</topic><topic>plant production</topic><topic>Plants - genetics</topic><topic>Plants - metabolism</topic><topic>Plants, Genetically Modified</topic><topic>Proteins</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - metabolism</topic><topic>transgenic</topic><topic>transient expression</topic><topic>transplastomic</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yusibov, Vidadi</creatorcontrib><creatorcontrib>Kushnir, Natasha</creatorcontrib><creatorcontrib>Streatfield, Stephen J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Annual review of plant biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yusibov, Vidadi</au><au>Kushnir, Natasha</au><au>Streatfield, Stephen J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody Production in Plants and Green Algae</atitle><jtitle>Annual review of plant biology</jtitle><addtitle>Annu Rev Plant Biol</addtitle><date>2016-04-29</date><risdate>2016</risdate><volume>67</volume><issue>1</issue><spage>669</spage><epage>701</epage><pages>669-701</pages><issn>1543-5008</issn><eissn>1545-2123</eissn><abstract>Monoclonal antibodies (mAbs) have a wide range of modern applications, including research, diagnostic, therapeutic, and industrial uses. Market demand for mAbs is high and continues to grow. Although mammalian systems, which currently dominate the biomanufacturing industry, produce effective and safe recombinant mAbs, they have a limited manufacturing capacity and high costs. Bacteria, yeast, and insect cell systems are highly scalable and cost effective but vary in their ability to produce appropriate posttranslationally modified mAbs. Plants and green algae are emerging as promising production platforms because of their time and cost efficiencies, scalability, lack of mammalian pathogens, and eukaryotic posttranslational protein modification machinery. So far, plant- and algae-derived mAbs have been produced predominantly as candidate therapeutics for infectious diseases and cancer. These candidates have been extensively evaluated in animal models, and some have shown efficacy in clinical trials. Here, we review ongoing efforts to advance the production of mAbs in plants and algae.</abstract><cop>United States</cop><pub>Annual Reviews</pub><pmid>26905655</pmid><doi>10.1146/annurev-arplant-043015-111812</doi><tpages>33</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1543-5008 |
| ispartof | Annual review of plant biology, 2016-04, Vol.67 (1), p.669-701 |
| issn | 1543-5008 1545-2123 |
| language | eng |
| recordid | cdi_pubmed_primary_26905655 |
| source | Annual Reviews; MEDLINE |
| subjects | Algae algae production Animal models Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Antibody Formation Aquatic plants Bacteria Chlorophyta - genetics Chlorophyta - metabolism Genetic Engineering glycoengineering Infectious diseases Mammals Monoclonal antibodies monoclonal antibody Plant biology plant production Plants - genetics Plants - metabolism Plants, Genetically Modified Proteins Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - metabolism transgenic transient expression transplastomic Yeasts |
| title | Antibody Production in Plants and Green Algae |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T00%3A57%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibody%20Production%20in%20Plants%20and%20Green%20Algae&rft.jtitle=Annual%20review%20of%20plant%20biology&rft.au=Yusibov,%20Vidadi&rft.date=2016-04-29&rft.volume=67&rft.issue=1&rft.spage=669&rft.epage=701&rft.pages=669-701&rft.issn=1543-5008&rft.eissn=1545-2123&rft_id=info:doi/10.1146/annurev-arplant-043015-111812&rft_dat=%3Cproquest_pubme%3E1808706474%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1792396668&rft_id=info:pmid/26905655&rfr_iscdi=true |