Antiproliferative activity of a series of cisplatin-based Pt()-acetylamido/carboxylato prodrugs

We report studies of a novel series of Pt( iv ) complexes exhibiting an asymmetric combination of acetylamido and carboxylato ligands in the axial positions. We demonstrate efficient synthesis of a series of analogues, differing in the alkyl chain length and hence lipophilicity, from a stable acetyl...

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