7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein

7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein

7-(Benzofuran-2-yl)-7-deazadeoxyguanosine ( BF dG) was synthesized and incorporated into an oligodeoxynucleotide (ODN). The single-stranded ODN containing BF dG shows 91-fold fluorescence enhancement upon binding of single-strand DNA binding protein. 7-(Benzofuran-2-yl)-7-deazadeoxyguanosine ( BF dG...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (19), p.389-3812
Hauptverfasser: Tokugawa, Munefumi, Masaki, Yoshiaki, Canggadibrata, Jan Christian, Kaneko, Kazuhei, Shiozawa, Takashi, Kanamori, Takashi, Grøtli, Morten, Wilhelmsson, L. Marcus, Sekine, Mitsuo, Seio, Kohji
Format: Artikel
Sprache:eng
Schlagworte:
Benzofurans - chemistry
Binding
Chemical Sciences
Deoxyribonucleic acid
DNA-Binding Proteins - chemistry
Fluorescence
Fluorescent Dyes - chemistry
Fysikalisk kemi
Kemi
Organic Chemistry
Organisk kemi
Physical Chemistry
Proteins
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Zusammenfassung:7-(Benzofuran-2-yl)-7-deazadeoxyguanosine ( BF dG) was synthesized and incorporated into an oligodeoxynucleotide (ODN). The single-stranded ODN containing BF dG shows 91-fold fluorescence enhancement upon binding of single-strand DNA binding protein. 7-(Benzofuran-2-yl)-7-deazadeoxyguanosine ( BF dG) was synthesized and incorporated into an oligodeoxynucleotide (ODN).
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c5cc09700b