Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats
The noninvasive assessment of flap viability in autologous reconstruction surgery is still an unmet clinical need. To cope with this problem, we developed a proof-of-principle fully automatized setup for fast time-gated diffuse optical tomography exploiting Mellin-Laplace transform to obtain three-d...
Gespeichert in:
| Veröffentlicht in: | Journal of biomedical optics 2016-02, Vol.21 (2), p.025004-025004 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 025004 |
|---|---|
| container_issue | 2 |
| container_start_page | 025004 |
| container_title | Journal of biomedical optics |
| container_volume | 21 |
| creator | Di Sieno, Laura Bettega, Georges Berger, Michel Hamou, Cynthia Aribert, Marion Mora, Alberto Dalla Puszka, Agathe Grateau, Henri Contini, Davide Hervé, Lionel Coll, Jean-Luc Dinten, Jean-Marc Pifferi, Antonio Planat-Chrétien, Anne |
| description | The noninvasive assessment of flap viability in autologous reconstruction surgery is still an unmet clinical need. To cope with this problem, we developed a proof-of-principle fully automatized setup for fast time-gated diffuse optical tomography exploiting Mellin-Laplace transform to obtain three-dimensional tomographic reconstructions of oxy- and deoxy-hemoglobin concentrations. We applied this method to perform preclinical tests on rats inducing total venous occlusion in the cutaneous abdominal flaps. Notwithstanding the use of just four source-detector couples, we could detect a spatially localized increase of deoxyhemoglobin following the occlusion (up to 550 μM in 54 min). Such capability to image spatio-temporal evolution of blood perfusion is a key issue for the noninvasive monitoring of flap viability. |
| doi_str_mv | 10.1117/1.JBO.21.2.025004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_26836208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1762680875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-68aafcde5337526b24dc115eb5ab6f177f37e771709af1d0fb8c2cd54f23d72a3</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxSMEoqXwAbggH-GQ4HESO8ttKZSCViqH5WxNYpt15cTBTlItnx6XlCLx5zSjmTc_jd7LsudACwAQr6H49PaqYFCwgrKa0upBdgo1pzljDTxMPW3KvOS8OcmexHhNKW34hj_OThhvSs5oc5od9_4GgyKDH-ywYLSLJhijjrHXw0S8IcbhSBaLrXV2OpIbOx3IZHudBx29W7QiyhozR038ONkOHZl8778GHA_HNwTJGHTn7LBudEzMgQSc4tPskUEX9bO7epZ9uXi_P7_Md1cfPp5vd3lXbaop5w2i6ZSuy1LUjLesUh1ArdsaW25ACFMKLQQIukEDipq26Vin6sqwUgmG5Vn2auUe0Mkx2B7DUXq08nK7k7czCsmtZMYCSfty1Y7Bf5vTs7K3sdPO4aD9HCUInqyjjaiTFFZpF3yMQZt7NlB5m44EmdKRDCSTazrp5sUdfm57re4vfsWRBPtVEEer5bWfw5Cs-c35bsc_oT9n25Ccd_rzu4u_1qMyCVv8C_v_R38ASmu2Kg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1762680875</pqid></control><display><type>article</type><title>Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats</title><source>Open Access: PubMed Central</source><source>MEDLINE</source><source>EZB Electronic Journals Library</source><creator>Di Sieno, Laura ; Bettega, Georges ; Berger, Michel ; Hamou, Cynthia ; Aribert, Marion ; Mora, Alberto Dalla ; Puszka, Agathe ; Grateau, Henri ; Contini, Davide ; Hervé, Lionel ; Coll, Jean-Luc ; Dinten, Jean-Marc ; Pifferi, Antonio ; Planat-Chrétien, Anne</creator><creatorcontrib>Di Sieno, Laura ; Bettega, Georges ; Berger, Michel ; Hamou, Cynthia ; Aribert, Marion ; Mora, Alberto Dalla ; Puszka, Agathe ; Grateau, Henri ; Contini, Davide ; Hervé, Lionel ; Coll, Jean-Luc ; Dinten, Jean-Marc ; Pifferi, Antonio ; Planat-Chrétien, Anne</creatorcontrib><description>The noninvasive assessment of flap viability in autologous reconstruction surgery is still an unmet clinical need. To cope with this problem, we developed a proof-of-principle fully automatized setup for fast time-gated diffuse optical tomography exploiting Mellin-Laplace transform to obtain three-dimensional tomographic reconstructions of oxy- and deoxy-hemoglobin concentrations. We applied this method to perform preclinical tests on rats inducing total venous occlusion in the cutaneous abdominal flaps. Notwithstanding the use of just four source-detector couples, we could detect a spatially localized increase of deoxyhemoglobin following the occlusion (up to 550 μM in 54 min). Such capability to image spatio-temporal evolution of blood perfusion is a key issue for the noninvasive monitoring of flap viability.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.JBO.21.2.025004</identifier><identifier>PMID: 26836208</identifier><language>eng</language><publisher>United States: Society of Photo-Optical Instrumentation Engineers</publisher><subject>Animals ; Bioengineering ; Female ; Image Processing, Computer-Assisted - methods ; Imaging ; Life Sciences ; Rats ; Rats, Wistar ; Surgical Flaps - physiology ; Tomography, Optical - methods</subject><ispartof>Journal of biomedical optics, 2016-02, Vol.21 (2), p.025004-025004</ispartof><rights>The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-68aafcde5337526b24dc115eb5ab6f177f37e771709af1d0fb8c2cd54f23d72a3</citedby><cites>FETCH-LOGICAL-c494t-68aafcde5337526b24dc115eb5ab6f177f37e771709af1d0fb8c2cd54f23d72a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26836208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01281208$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Sieno, Laura</creatorcontrib><creatorcontrib>Bettega, Georges</creatorcontrib><creatorcontrib>Berger, Michel</creatorcontrib><creatorcontrib>Hamou, Cynthia</creatorcontrib><creatorcontrib>Aribert, Marion</creatorcontrib><creatorcontrib>Mora, Alberto Dalla</creatorcontrib><creatorcontrib>Puszka, Agathe</creatorcontrib><creatorcontrib>Grateau, Henri</creatorcontrib><creatorcontrib>Contini, Davide</creatorcontrib><creatorcontrib>Hervé, Lionel</creatorcontrib><creatorcontrib>Coll, Jean-Luc</creatorcontrib><creatorcontrib>Dinten, Jean-Marc</creatorcontrib><creatorcontrib>Pifferi, Antonio</creatorcontrib><creatorcontrib>Planat-Chrétien, Anne</creatorcontrib><title>Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats</title><title>Journal of biomedical optics</title><addtitle>J. Biomed. Opt</addtitle><description>The noninvasive assessment of flap viability in autologous reconstruction surgery is still an unmet clinical need. To cope with this problem, we developed a proof-of-principle fully automatized setup for fast time-gated diffuse optical tomography exploiting Mellin-Laplace transform to obtain three-dimensional tomographic reconstructions of oxy- and deoxy-hemoglobin concentrations. We applied this method to perform preclinical tests on rats inducing total venous occlusion in the cutaneous abdominal flaps. Notwithstanding the use of just four source-detector couples, we could detect a spatially localized increase of deoxyhemoglobin following the occlusion (up to 550 μM in 54 min). Such capability to image spatio-temporal evolution of blood perfusion is a key issue for the noninvasive monitoring of flap viability.</description><subject>Animals</subject><subject>Bioengineering</subject><subject>Female</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Life Sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Surgical Flaps - physiology</subject><subject>Tomography, Optical - methods</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxSMEoqXwAbggH-GQ4HESO8ttKZSCViqH5WxNYpt15cTBTlItnx6XlCLx5zSjmTc_jd7LsudACwAQr6H49PaqYFCwgrKa0upBdgo1pzljDTxMPW3KvOS8OcmexHhNKW34hj_OThhvSs5oc5od9_4GgyKDH-ywYLSLJhijjrHXw0S8IcbhSBaLrXV2OpIbOx3IZHudBx29W7QiyhozR038ONkOHZl8778GHA_HNwTJGHTn7LBudEzMgQSc4tPskUEX9bO7epZ9uXi_P7_Md1cfPp5vd3lXbaop5w2i6ZSuy1LUjLesUh1ArdsaW25ACFMKLQQIukEDipq26Vin6sqwUgmG5Vn2auUe0Mkx2B7DUXq08nK7k7czCsmtZMYCSfty1Y7Bf5vTs7K3sdPO4aD9HCUInqyjjaiTFFZpF3yMQZt7NlB5m44EmdKRDCSTazrp5sUdfm57re4vfsWRBPtVEEer5bWfw5Cs-c35bsc_oT9n25Ccd_rzu4u_1qMyCVv8C_v_R38ASmu2Kg</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Di Sieno, Laura</creator><creator>Bettega, Georges</creator><creator>Berger, Michel</creator><creator>Hamou, Cynthia</creator><creator>Aribert, Marion</creator><creator>Mora, Alberto Dalla</creator><creator>Puszka, Agathe</creator><creator>Grateau, Henri</creator><creator>Contini, Davide</creator><creator>Hervé, Lionel</creator><creator>Coll, Jean-Luc</creator><creator>Dinten, Jean-Marc</creator><creator>Pifferi, Antonio</creator><creator>Planat-Chrétien, Anne</creator><general>Society of Photo-Optical Instrumentation Engineers</general><general>Society of Photo-optical Instrumentation Engineers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20160201</creationdate><title>Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats</title><author>Di Sieno, Laura ; Bettega, Georges ; Berger, Michel ; Hamou, Cynthia ; Aribert, Marion ; Mora, Alberto Dalla ; Puszka, Agathe ; Grateau, Henri ; Contini, Davide ; Hervé, Lionel ; Coll, Jean-Luc ; Dinten, Jean-Marc ; Pifferi, Antonio ; Planat-Chrétien, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-68aafcde5337526b24dc115eb5ab6f177f37e771709af1d0fb8c2cd54f23d72a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bioengineering</topic><topic>Female</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Imaging</topic><topic>Life Sciences</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Surgical Flaps - physiology</topic><topic>Tomography, Optical - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Sieno, Laura</creatorcontrib><creatorcontrib>Bettega, Georges</creatorcontrib><creatorcontrib>Berger, Michel</creatorcontrib><creatorcontrib>Hamou, Cynthia</creatorcontrib><creatorcontrib>Aribert, Marion</creatorcontrib><creatorcontrib>Mora, Alberto Dalla</creatorcontrib><creatorcontrib>Puszka, Agathe</creatorcontrib><creatorcontrib>Grateau, Henri</creatorcontrib><creatorcontrib>Contini, Davide</creatorcontrib><creatorcontrib>Hervé, Lionel</creatorcontrib><creatorcontrib>Coll, Jean-Luc</creatorcontrib><creatorcontrib>Dinten, Jean-Marc</creatorcontrib><creatorcontrib>Pifferi, Antonio</creatorcontrib><creatorcontrib>Planat-Chrétien, Anne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of biomedical optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Sieno, Laura</au><au>Bettega, Georges</au><au>Berger, Michel</au><au>Hamou, Cynthia</au><au>Aribert, Marion</au><au>Mora, Alberto Dalla</au><au>Puszka, Agathe</au><au>Grateau, Henri</au><au>Contini, Davide</au><au>Hervé, Lionel</au><au>Coll, Jean-Luc</au><au>Dinten, Jean-Marc</au><au>Pifferi, Antonio</au><au>Planat-Chrétien, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats</atitle><jtitle>Journal of biomedical optics</jtitle><addtitle>J. Biomed. Opt</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>21</volume><issue>2</issue><spage>025004</spage><epage>025004</epage><pages>025004-025004</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><abstract>The noninvasive assessment of flap viability in autologous reconstruction surgery is still an unmet clinical need. To cope with this problem, we developed a proof-of-principle fully automatized setup for fast time-gated diffuse optical tomography exploiting Mellin-Laplace transform to obtain three-dimensional tomographic reconstructions of oxy- and deoxy-hemoglobin concentrations. We applied this method to perform preclinical tests on rats inducing total venous occlusion in the cutaneous abdominal flaps. Notwithstanding the use of just four source-detector couples, we could detect a spatially localized increase of deoxyhemoglobin following the occlusion (up to 550 μM in 54 min). Such capability to image spatio-temporal evolution of blood perfusion is a key issue for the noninvasive monitoring of flap viability.</abstract><cop>United States</cop><pub>Society of Photo-Optical Instrumentation Engineers</pub><pmid>26836208</pmid><doi>10.1117/1.JBO.21.2.025004</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-3668 |
| ispartof | Journal of biomedical optics, 2016-02, Vol.21 (2), p.025004-025004 |
| issn | 1083-3668 1560-2281 |
| language | eng |
| recordid | cdi_pubmed_primary_26836208 |
| source | Open Access: PubMed Central; MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Bioengineering Female Image Processing, Computer-Assisted - methods Imaging Life Sciences Rats Rats, Wistar Surgical Flaps - physiology Tomography, Optical - methods |
| title | Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T11%3A29%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Toward%20noninvasive%20assessment%20of%20flap%20viability%20with%20time-resolved%20diffuse%20optical%20tomography:%20a%20preclinical%20test%20on%20rats&rft.jtitle=Journal%20of%20biomedical%20optics&rft.au=Di%20Sieno,%20Laura&rft.date=2016-02-01&rft.volume=21&rft.issue=2&rft.spage=025004&rft.epage=025004&rft.pages=025004-025004&rft.issn=1083-3668&rft.eissn=1560-2281&rft_id=info:doi/10.1117/1.JBO.21.2.025004&rft_dat=%3Cproquest_pubme%3E1762680875%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1762680875&rft_id=info:pmid/26836208&rfr_iscdi=true |