Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity

In this study we compared the effects of a diverse set of natural polyphenolics ligands on in silico interactive modelling, in vitro anti-aggregative properties and neuronal toxicity of β amyloid. The β amyloid-binding characteristics of optimised structural conformations of polyphenols with ascribe...

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Veröffentlicht in:	Food & function 2016-02, Vol.7 (2), p.1138-1146
Hauptverfasser:	Das, Sukanya, Stark, Lina, Musgrave, Ian F, Pukala, Tara, Smid, Scott D
Format:	Artikel
Sprache:	eng
Schlagworte:	alzheimers-disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Animals Biphenyl Compounds - pharmacology catechol-type flavonoids Cell Survival - drug effects Clinical Medicine endocannabinoid system Flavonoids - pharmacology Fluorescent Dyes - analysis Hydrolyzable Tannins - pharmacology in-vitro inhibitors Klinisk medicin Lignans - pharmacology Luteolin - pharmacology memory impairment Microscopy, Electron, Transmission mouse model Neuroprotective Agents - pharmacology nuclear factor PC12 Cells Peptide Fragments - antagonists & inhibitors Peptide Fragments - metabolism Polyphenols - pharmacology protein Rats Thiazoles - analysis thioflavin-t
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