Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99m Tc-tetrofosmin: Method and validation
The objective of this study was to measure myocardial blood flow (MBF) in humans using Tc-tetrofosmin and dynamic single-photon emission computed tomography (SPECT). Dynamic SPECT using Tc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT d...
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| Veröffentlicht in: | Journal of nuclear cardiology 2017-02, Vol.24 (1), p.268 |
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| creator | Shrestha, Uttam Sciammarella, Maria Alhassen, Fares Yeghiazarians, Yerem Ellin, Justin Verdin, Emily Boyle, Andrew Seo, Youngho Botvinick, Elias H Gullberg, Grant T |
| description | The objective of this study was to measure myocardial blood flow (MBF) in humans using
Tc-tetrofosmin and dynamic single-photon emission computed tomography (SPECT).
Dynamic SPECT using
Tc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT data were reconstructed using a 4D-spatiotemporal iterative reconstruction method. The data corresponding to 9 patients were used to determine the flow-extraction curve for
Tc-tefrofosmin while data from the remaining 7 patients were used for method validation. The nonlinear tracer correction parameters A and B for
Tc-tefrofosmin were estimated for the 9 patients by fitting the flow-extraction curve [Formula: see text] for K
values estimated with
Tc-tefrofosmin using SPECT and MBF values estimated with
N-NH
using PET. These parameters were then used to calculate MBF and coronary flow reserve (CFR) in three coronary territories (LAD, RCA, and LCX) using SPECT for an independent cohort of 7 patients. The results were then compared with that estimated with
N-NH
PET. The flow-dependent permeability surface-area product (PS) for
Tc-tefrofosmin was also estimated.
The estimated flow-extraction parameters for
Tc-tefrofosmin were found to be A = 0.91 ± 0.11, B = 0.34 ± 0.20 (R
= 0.49). The range of MBF in LAD, RCA, and LCX was 0.44-3.81 mL/min/g. The MBF between PET and SPECT in the group of independent cohort of 7 patients showed statistically significant correlation, r = 0.71 (P |
| doi_str_mv | 10.1007/s12350-015-0320-3 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_26715603</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>26715603</sourcerecordid><originalsourceid>FETCH-pubmed_primary_267156033</originalsourceid><addsrcrecordid>eNqFjs1KAzEURoMgbf15ADdyXyB6MyFT4rZU3BQEZ1_uTDJtJD9lkiiz9M1V1LWrs_gOH4exG4F3AnF9n0UjFXIUiqNskMszthJKNrxVSizZRc6viKil1gu2bNq1UC3KFfvYWcp1ssHGAmkE6nPytVgIcxpoMo489D4lA6NP7-AiHGugmKFmFw9g5kjBDfCjDvDyvN10QNGA1gG6gRdbpjSmHFx8gJ0tx6-n7_mNvDNUXIpX7Hwkn-31Ly_Z7eO22zzxU-2DNfvT5AJN8_6vWf4rfAJstlL7</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99m Tc-tetrofosmin: Method and validation</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Shrestha, Uttam ; Sciammarella, Maria ; Alhassen, Fares ; Yeghiazarians, Yerem ; Ellin, Justin ; Verdin, Emily ; Boyle, Andrew ; Seo, Youngho ; Botvinick, Elias H ; Gullberg, Grant T</creator><creatorcontrib>Shrestha, Uttam ; Sciammarella, Maria ; Alhassen, Fares ; Yeghiazarians, Yerem ; Ellin, Justin ; Verdin, Emily ; Boyle, Andrew ; Seo, Youngho ; Botvinick, Elias H ; Gullberg, Grant T</creatorcontrib><description>The objective of this study was to measure myocardial blood flow (MBF) in humans using
Tc-tetrofosmin and dynamic single-photon emission computed tomography (SPECT).
Dynamic SPECT using
Tc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT data were reconstructed using a 4D-spatiotemporal iterative reconstruction method. The data corresponding to 9 patients were used to determine the flow-extraction curve for
Tc-tefrofosmin while data from the remaining 7 patients were used for method validation. The nonlinear tracer correction parameters A and B for
Tc-tefrofosmin were estimated for the 9 patients by fitting the flow-extraction curve [Formula: see text] for K
values estimated with
Tc-tefrofosmin using SPECT and MBF values estimated with
N-NH
using PET. These parameters were then used to calculate MBF and coronary flow reserve (CFR) in three coronary territories (LAD, RCA, and LCX) using SPECT for an independent cohort of 7 patients. The results were then compared with that estimated with
N-NH
PET. The flow-dependent permeability surface-area product (PS) for
Tc-tefrofosmin was also estimated.
The estimated flow-extraction parameters for
Tc-tefrofosmin were found to be A = 0.91 ± 0.11, B = 0.34 ± 0.20 (R
= 0.49). The range of MBF in LAD, RCA, and LCX was 0.44-3.81 mL/min/g. The MBF between PET and SPECT in the group of independent cohort of 7 patients showed statistically significant correlation, r = 0.71 (P < .001). However, the corresponding CFR correlation was moderate r = 0.39 yet statistically significant (P = .037). The PS for
Tc-tefrofosmin was (0.019 ± 0.10)*MBF + (0.32 ± 0.16).
Dynamic cardiac SPECT using
Tc-tetrofosmin and a clinical two-headed SPECT/CT scanner can be a useful tool for estimation of MBF.</description><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-015-0320-3</identifier><identifier>PMID: 26715603</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Aged, 80 and over ; Algorithms ; Blood Flow Velocity ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - physiopathology ; Coronary Circulation - physiology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - physiopathology ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Middle Aged ; Myocardial Perfusion Imaging - methods ; Organophosphorus Compounds ; Organotechnetium Compounds ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon - methods</subject><ispartof>Journal of nuclear cardiology, 2017-02, Vol.24 (1), p.268</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26715603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shrestha, Uttam</creatorcontrib><creatorcontrib>Sciammarella, Maria</creatorcontrib><creatorcontrib>Alhassen, Fares</creatorcontrib><creatorcontrib>Yeghiazarians, Yerem</creatorcontrib><creatorcontrib>Ellin, Justin</creatorcontrib><creatorcontrib>Verdin, Emily</creatorcontrib><creatorcontrib>Boyle, Andrew</creatorcontrib><creatorcontrib>Seo, Youngho</creatorcontrib><creatorcontrib>Botvinick, Elias H</creatorcontrib><creatorcontrib>Gullberg, Grant T</creatorcontrib><title>Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99m Tc-tetrofosmin: Method and validation</title><title>Journal of nuclear cardiology</title><addtitle>J Nucl Cardiol</addtitle><description>The objective of this study was to measure myocardial blood flow (MBF) in humans using
Tc-tetrofosmin and dynamic single-photon emission computed tomography (SPECT).
Dynamic SPECT using
Tc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT data were reconstructed using a 4D-spatiotemporal iterative reconstruction method. The data corresponding to 9 patients were used to determine the flow-extraction curve for
Tc-tefrofosmin while data from the remaining 7 patients were used for method validation. The nonlinear tracer correction parameters A and B for
Tc-tefrofosmin were estimated for the 9 patients by fitting the flow-extraction curve [Formula: see text] for K
values estimated with
Tc-tefrofosmin using SPECT and MBF values estimated with
N-NH
using PET. These parameters were then used to calculate MBF and coronary flow reserve (CFR) in three coronary territories (LAD, RCA, and LCX) using SPECT for an independent cohort of 7 patients. The results were then compared with that estimated with
N-NH
PET. The flow-dependent permeability surface-area product (PS) for
Tc-tefrofosmin was also estimated.
The estimated flow-extraction parameters for
Tc-tefrofosmin were found to be A = 0.91 ± 0.11, B = 0.34 ± 0.20 (R
= 0.49). The range of MBF in LAD, RCA, and LCX was 0.44-3.81 mL/min/g. The MBF between PET and SPECT in the group of independent cohort of 7 patients showed statistically significant correlation, r = 0.71 (P < .001). However, the corresponding CFR correlation was moderate r = 0.39 yet statistically significant (P = .037). The PS for
Tc-tefrofosmin was (0.019 ± 0.10)*MBF + (0.32 ± 0.16).
Dynamic cardiac SPECT using
Tc-tetrofosmin and a clinical two-headed SPECT/CT scanner can be a useful tool for estimation of MBF.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Algorithms</subject><subject>Blood Flow Velocity</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Circulation - physiology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - physiopathology</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Organophosphorus Compounds</subject><subject>Organotechnetium Compounds</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjs1KAzEURoMgbf15ADdyXyB6MyFT4rZU3BQEZ1_uTDJtJD9lkiiz9M1V1LWrs_gOH4exG4F3AnF9n0UjFXIUiqNskMszthJKNrxVSizZRc6viKil1gu2bNq1UC3KFfvYWcp1ssHGAmkE6nPytVgIcxpoMo489D4lA6NP7-AiHGugmKFmFw9g5kjBDfCjDvDyvN10QNGA1gG6gRdbpjSmHFx8gJ0tx6-n7_mNvDNUXIpX7Hwkn-31Ly_Z7eO22zzxU-2DNfvT5AJN8_6vWf4rfAJstlL7</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Shrestha, Uttam</creator><creator>Sciammarella, Maria</creator><creator>Alhassen, Fares</creator><creator>Yeghiazarians, Yerem</creator><creator>Ellin, Justin</creator><creator>Verdin, Emily</creator><creator>Boyle, Andrew</creator><creator>Seo, Youngho</creator><creator>Botvinick, Elias H</creator><creator>Gullberg, Grant T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201702</creationdate><title>Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99m Tc-tetrofosmin: Method and validation</title><author>Shrestha, Uttam ; Sciammarella, Maria ; Alhassen, Fares ; Yeghiazarians, Yerem ; Ellin, Justin ; Verdin, Emily ; Boyle, Andrew ; Seo, Youngho ; Botvinick, Elias H ; Gullberg, Grant T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_267156033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Algorithms</topic><topic>Blood Flow Velocity</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Circulation - physiology</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - physiopathology</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Middle Aged</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>Organophosphorus Compounds</topic><topic>Organotechnetium Compounds</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shrestha, Uttam</creatorcontrib><creatorcontrib>Sciammarella, Maria</creatorcontrib><creatorcontrib>Alhassen, Fares</creatorcontrib><creatorcontrib>Yeghiazarians, Yerem</creatorcontrib><creatorcontrib>Ellin, Justin</creatorcontrib><creatorcontrib>Verdin, Emily</creatorcontrib><creatorcontrib>Boyle, Andrew</creatorcontrib><creatorcontrib>Seo, Youngho</creatorcontrib><creatorcontrib>Botvinick, Elias H</creatorcontrib><creatorcontrib>Gullberg, Grant T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shrestha, Uttam</au><au>Sciammarella, Maria</au><au>Alhassen, Fares</au><au>Yeghiazarians, Yerem</au><au>Ellin, Justin</au><au>Verdin, Emily</au><au>Boyle, Andrew</au><au>Seo, Youngho</au><au>Botvinick, Elias H</au><au>Gullberg, Grant T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99m Tc-tetrofosmin: Method and validation</atitle><jtitle>Journal of nuclear cardiology</jtitle><addtitle>J Nucl Cardiol</addtitle><date>2017-02</date><risdate>2017</risdate><volume>24</volume><issue>1</issue><spage>268</spage><pages>268-</pages><eissn>1532-6551</eissn><abstract>The objective of this study was to measure myocardial blood flow (MBF) in humans using
Tc-tetrofosmin and dynamic single-photon emission computed tomography (SPECT).
Dynamic SPECT using
Tc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT data were reconstructed using a 4D-spatiotemporal iterative reconstruction method. The data corresponding to 9 patients were used to determine the flow-extraction curve for
Tc-tefrofosmin while data from the remaining 7 patients were used for method validation. The nonlinear tracer correction parameters A and B for
Tc-tefrofosmin were estimated for the 9 patients by fitting the flow-extraction curve [Formula: see text] for K
values estimated with
Tc-tefrofosmin using SPECT and MBF values estimated with
N-NH
using PET. These parameters were then used to calculate MBF and coronary flow reserve (CFR) in three coronary territories (LAD, RCA, and LCX) using SPECT for an independent cohort of 7 patients. The results were then compared with that estimated with
N-NH
PET. The flow-dependent permeability surface-area product (PS) for
Tc-tefrofosmin was also estimated.
The estimated flow-extraction parameters for
Tc-tefrofosmin were found to be A = 0.91 ± 0.11, B = 0.34 ± 0.20 (R
= 0.49). The range of MBF in LAD, RCA, and LCX was 0.44-3.81 mL/min/g. The MBF between PET and SPECT in the group of independent cohort of 7 patients showed statistically significant correlation, r = 0.71 (P < .001). However, the corresponding CFR correlation was moderate r = 0.39 yet statistically significant (P = .037). The PS for
Tc-tefrofosmin was (0.019 ± 0.10)*MBF + (0.32 ± 0.16).
Dynamic cardiac SPECT using
Tc-tetrofosmin and a clinical two-headed SPECT/CT scanner can be a useful tool for estimation of MBF.</abstract><cop>United States</cop><pmid>26715603</pmid><doi>10.1007/s12350-015-0320-3</doi></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aged, 80 and over Algorithms Blood Flow Velocity Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - physiopathology Coronary Circulation - physiology Coronary Vessels - diagnostic imaging Coronary Vessels - physiopathology Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Middle Aged Myocardial Perfusion Imaging - methods Organophosphorus Compounds Organotechnetium Compounds Radiopharmaceuticals Reproducibility of Results Sensitivity and Specificity Tomography, Emission-Computed, Single-Photon - methods |
| title | Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99m Tc-tetrofosmin: Method and validation |
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