Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs

The objective of this study was to verify the effects of ethanol consumption and alcohol detoxification on the biomechanics, area and thickness of cortical and trabecular bone in rat femur. This was an experimental study in which 18 male Wistar rats were used, with 40 days of age, weighing 179 ± 2.5...

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Veröffentlicht in:Brazilian journal of biology 2015-11, Vol.75 (4), p.983
Hauptverfasser: Garcia, J A D, Souza, A L T, Cruz, L H C, Marques, P P, Camilli, J A, Nakagaki, W R, Esteves, A, Rossi-Junior, W C, Fernandes, G J M, Guerra, F D, Soares, E A
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container_end_page
container_issue 4
container_start_page 983
container_title Brazilian journal of biology
container_volume 75
creator Garcia, J A D
Souza, A L T
Cruz, L H C
Marques, P P
Camilli, J A
Nakagaki, W R
Esteves, A
Rossi-Junior, W C
Fernandes, G J M
Guerra, F D
Soares, E A
description The objective of this study was to verify the effects of ethanol consumption and alcohol detoxification on the biomechanics, area and thickness of cortical and trabecular bone in rat femur. This was an experimental study in which 18 male Wistar rats were used, with 40 days of age, weighing 179 ± 2.5 g. The rats were divided into three groups (n=06): CT (control), AC (chronic alcoholic), DT (detoxification). After experimental procedures, the animals were euthanized by an overdose of the anesthetic and their femurs were collected for mechanical testing and histological processing. All animals did not present malnutrition or dehydration during experimentation period. Morphometric analysis of cortical and trabecular bones in rat femurs demonstrated that AC animals showed inferior dimensions and alcohol detoxification (DT) allowed an enhancement in area and thickness of cortical and trabecular bone. Material and structural properties data of AC group highlighted the harmful effects of ethanol on bone mechanical properties. The results of this study demonstrated that chronic alcoholic rats (AC) presented major bone damage in all analyzed variables. Those findings suggested that alcohol detoxification is highly suggested in pre-operative planning and this corroborates to the success of bone surgery and bone tissue repair. Thanks to the financial support offered by PROBIC - UNIFENAS.
doi_str_mv 10.1590/1519-6984.04814
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subjects Animals
Biomechanical Phenomena
Ethanol - pharmacokinetics
Ethanol - pharmacology
Femur - drug effects
Inactivation, Metabolic
Male
Rats
Rats, Wistar
title Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
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