Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury
Background/Aims: This study aimed to examine antioxidants in patients with acute kidney injury (AKI) and determine whether serum protein thiol levels are associated with all-cause 90-day mortality in patients with hospital-acquired AKI. Methods: According to the RIFLE criteria, 160 patients with hos...
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| Veröffentlicht in: | Kidney & blood pressure research 2015-12, Vol.40 (6), p.623-629 |
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| container_title | Kidney & blood pressure research |
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| creator | Qian, Jing Fang, Junyan Zhu, Qiuyu Ma, Shuai Wang, Wenji Zheng, Ying Hao, Guihua Deng, Bo Zhao, Xiaojiao Ding, Feng |
| description | Background/Aims: This study aimed to examine antioxidants in patients with acute kidney injury (AKI) and determine whether serum protein thiol levels are associated with all-cause 90-day mortality in patients with hospital-acquired AKI. Methods: According to the RIFLE criteria, 160 patients with hospital-acquired AKI were enrolled in our prospective cohort study. As controls, 72 critically ill patients without AKI and 72 age and sex-matched healthy subjects were also recruited. Serum protein thiol levels were analyzed in relation to all-cause mortality of patients with AKI. Results: Serum protein thiol levels in AKI patients were lower than those in healthy people (p=0.010). Protein thiol levels showed a weak but significant positive correlation with serum albumin levels. The 90-day overall mortality rate was higher in AKI patients with high serum protein thiol levels than in those with low levels (p=0.032 by log rank test). In multivariate analysis (Cox regression), serum protein thiol levels (p=0.031) were independently associated with 90-day overall mortality after adjustment for age, sex, sepsis, and the Acute Physiology and Chronic Health Evaluation II score. Conclusions: Patients with hospital-acquired AKI have remarkably low serum protein thiol levels. Elevated protein thiol levels are associated with 90-day overall mortality in hospital-acquired AKI. |
| doi_str_mv | 10.1159/000368538 |
| format | Article |
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Methods: According to the RIFLE criteria, 160 patients with hospital-acquired AKI were enrolled in our prospective cohort study. As controls, 72 critically ill patients without AKI and 72 age and sex-matched healthy subjects were also recruited. Serum protein thiol levels were analyzed in relation to all-cause mortality of patients with AKI. Results: Serum protein thiol levels in AKI patients were lower than those in healthy people (p=0.010). Protein thiol levels showed a weak but significant positive correlation with serum albumin levels. The 90-day overall mortality rate was higher in AKI patients with high serum protein thiol levels than in those with low levels (p=0.032 by log rank test). In multivariate analysis (Cox regression), serum protein thiol levels (p=0.031) were independently associated with 90-day overall mortality after adjustment for age, sex, sepsis, and the Acute Physiology and Chronic Health Evaluation II score. Conclusions: Patients with hospital-acquired AKI have remarkably low serum protein thiol levels. Elevated protein thiol levels are associated with 90-day overall mortality in hospital-acquired AKI.</description><identifier>ISSN: 1420-4096</identifier><identifier>EISSN: 1423-0143</identifier><identifier>DOI: 10.1159/000368538</identifier><identifier>PMID: 26672792</identifier><identifier>CODEN: RPBIEL</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acute kidney injury ; Acute Kidney Injury - blood ; Acute Kidney Injury - mortality ; Adult ; Aged ; APACHE ; Blood Proteins - analysis ; China - epidemiology ; Cohort Studies ; Critical Illness - mortality ; Female ; Hospital Mortality ; Humans ; Iatrogenic Disease ; Male ; Middle Aged ; Mortality ; Original Paper ; Prospective Studies ; Risk Assessment ; Serum Albumin - analysis ; Serum protein thiols ; Sulfhydryl Compounds - blood ; Survival Analysis ; Treatment Outcome</subject><ispartof>Kidney & blood pressure research, 2015-12, Vol.40 (6), p.623-629</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>2015 S. Karger AG, Basel.</rights><rights>Copyright S. Karger AG Jan 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-6fb0ce7eae08f549a3ed5250ec07b5c63dbdaea807053d1375a385a9c6f7ada23</citedby><cites>FETCH-LOGICAL-c533t-6fb0ce7eae08f549a3ed5250ec07b5c63dbdaea807053d1375a385a9c6f7ada23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,2102,27635,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26672792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qian, Jing</creatorcontrib><creatorcontrib>Fang, Junyan</creatorcontrib><creatorcontrib>Zhu, Qiuyu</creatorcontrib><creatorcontrib>Ma, Shuai</creatorcontrib><creatorcontrib>Wang, Wenji</creatorcontrib><creatorcontrib>Zheng, Ying</creatorcontrib><creatorcontrib>Hao, Guihua</creatorcontrib><creatorcontrib>Deng, Bo</creatorcontrib><creatorcontrib>Zhao, Xiaojiao</creatorcontrib><creatorcontrib>Ding, Feng</creatorcontrib><title>Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury</title><title>Kidney & blood pressure research</title><addtitle>Kidney Blood Press Res</addtitle><description>Background/Aims: This study aimed to examine antioxidants in patients with acute kidney injury (AKI) and determine whether serum protein thiol levels are associated with all-cause 90-day mortality in patients with hospital-acquired AKI. Methods: According to the RIFLE criteria, 160 patients with hospital-acquired AKI were enrolled in our prospective cohort study. As controls, 72 critically ill patients without AKI and 72 age and sex-matched healthy subjects were also recruited. Serum protein thiol levels were analyzed in relation to all-cause mortality of patients with AKI. Results: Serum protein thiol levels in AKI patients were lower than those in healthy people (p=0.010). Protein thiol levels showed a weak but significant positive correlation with serum albumin levels. The 90-day overall mortality rate was higher in AKI patients with high serum protein thiol levels than in those with low levels (p=0.032 by log rank test). In multivariate analysis (Cox regression), serum protein thiol levels (p=0.031) were independently associated with 90-day overall mortality after adjustment for age, sex, sepsis, and the Acute Physiology and Chronic Health Evaluation II score. Conclusions: Patients with hospital-acquired AKI have remarkably low serum protein thiol levels. Elevated protein thiol levels are associated with 90-day overall mortality in hospital-acquired AKI.</description><subject>Acute kidney injury</subject><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - mortality</subject><subject>Adult</subject><subject>Aged</subject><subject>APACHE</subject><subject>Blood Proteins - analysis</subject><subject>China - epidemiology</subject><subject>Cohort Studies</subject><subject>Critical Illness - mortality</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Iatrogenic Disease</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Original Paper</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Serum Albumin - analysis</subject><subject>Serum protein thiols</subject><subject>Sulfhydryl Compounds - blood</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>1420-4096</issn><issn>1423-0143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNpt0U1v1DAQBmALUdEPOHBHKBKX9hCw4zh2jksFdNWVKFDO1sSetF6y8dZ2QPvvcbvbRao4-UOP3hl7CHnN6HvGRPuBUsobJbh6Ro5YXfGSspo_f9jTsqZtc0iOY1xmJiitXpDDqmlkJdvqiHz7gWFaFVfBJ3RjcX3r_FAs8DcOscjnK0gOxxSLPy7dFhc-rl2CoZyZu8kFtMXMTAmLS2dH3BTzcTmFzUty0MMQ8dVuPSE_P3-6Pr8oF1-_zM9ni9IIzlPZ9B01KBGQql7ULXC0ohIUDZWdMA23nQUERSUV3DIuBXAloDVNL8FCxU_IfJtrPSz1OrgVhI324PTDhQ83GkJyZkAtLQWLpu5AiBoqUB1I23bW9hYa02HOOt1mrYO_mzAmvXLR4DDAiH6KmknBWtXmX8v03RO69FMY80vvlZCKMa6yOtsqE3yMAft9g4zq-5np_cyyfbtLnLoV2r18HNK_kr8g3GDYg8uP37cRem37rN78V-2q_AWpyKZa</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Qian, Jing</creator><creator>Fang, Junyan</creator><creator>Zhu, Qiuyu</creator><creator>Ma, Shuai</creator><creator>Wang, Wenji</creator><creator>Zheng, Ying</creator><creator>Hao, Guihua</creator><creator>Deng, Bo</creator><creator>Zhao, Xiaojiao</creator><creator>Ding, Feng</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20151201</creationdate><title>Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury</title><author>Qian, Jing ; Fang, Junyan ; Zhu, Qiuyu ; Ma, Shuai ; Wang, Wenji ; Zheng, Ying ; Hao, Guihua ; Deng, Bo ; Zhao, Xiaojiao ; Ding, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-6fb0ce7eae08f549a3ed5250ec07b5c63dbdaea807053d1375a385a9c6f7ada23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute kidney injury</topic><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - mortality</topic><topic>Adult</topic><topic>Aged</topic><topic>APACHE</topic><topic>Blood Proteins - analysis</topic><topic>China - epidemiology</topic><topic>Cohort Studies</topic><topic>Critical Illness - mortality</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Iatrogenic Disease</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Original Paper</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Serum Albumin - analysis</topic><topic>Serum protein thiols</topic><topic>Sulfhydryl Compounds - blood</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qian, Jing</creatorcontrib><creatorcontrib>Fang, Junyan</creatorcontrib><creatorcontrib>Zhu, Qiuyu</creatorcontrib><creatorcontrib>Ma, Shuai</creatorcontrib><creatorcontrib>Wang, Wenji</creatorcontrib><creatorcontrib>Zheng, Ying</creatorcontrib><creatorcontrib>Hao, Guihua</creatorcontrib><creatorcontrib>Deng, Bo</creatorcontrib><creatorcontrib>Zhao, Xiaojiao</creatorcontrib><creatorcontrib>Ding, Feng</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Kidney & blood pressure research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qian, Jing</au><au>Fang, Junyan</au><au>Zhu, Qiuyu</au><au>Ma, Shuai</au><au>Wang, Wenji</au><au>Zheng, Ying</au><au>Hao, Guihua</au><au>Deng, Bo</au><au>Zhao, Xiaojiao</au><au>Ding, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury</atitle><jtitle>Kidney & blood pressure research</jtitle><addtitle>Kidney Blood Press Res</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>40</volume><issue>6</issue><spage>623</spage><epage>629</epage><pages>623-629</pages><issn>1420-4096</issn><eissn>1423-0143</eissn><coden>RPBIEL</coden><abstract>Background/Aims: This study aimed to examine antioxidants in patients with acute kidney injury (AKI) and determine whether serum protein thiol levels are associated with all-cause 90-day mortality in patients with hospital-acquired AKI. Methods: According to the RIFLE criteria, 160 patients with hospital-acquired AKI were enrolled in our prospective cohort study. As controls, 72 critically ill patients without AKI and 72 age and sex-matched healthy subjects were also recruited. Serum protein thiol levels were analyzed in relation to all-cause mortality of patients with AKI. Results: Serum protein thiol levels in AKI patients were lower than those in healthy people (p=0.010). Protein thiol levels showed a weak but significant positive correlation with serum albumin levels. The 90-day overall mortality rate was higher in AKI patients with high serum protein thiol levels than in those with low levels (p=0.032 by log rank test). In multivariate analysis (Cox regression), serum protein thiol levels (p=0.031) were independently associated with 90-day overall mortality after adjustment for age, sex, sepsis, and the Acute Physiology and Chronic Health Evaluation II score. Conclusions: Patients with hospital-acquired AKI have remarkably low serum protein thiol levels. Elevated protein thiol levels are associated with 90-day overall mortality in hospital-acquired AKI.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>26672792</pmid><doi>10.1159/000368538</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute kidney injury Acute Kidney Injury - blood Acute Kidney Injury - mortality Adult Aged APACHE Blood Proteins - analysis China - epidemiology Cohort Studies Critical Illness - mortality Female Hospital Mortality Humans Iatrogenic Disease Male Middle Aged Mortality Original Paper Prospective Studies Risk Assessment Serum Albumin - analysis Serum protein thiols Sulfhydryl Compounds - blood Survival Analysis Treatment Outcome |
| title | Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury |
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