Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?
The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the wor...
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| Veröffentlicht in: | Human vaccines & immunotherapeutics 2016-02, Vol.12 (2), p.344-350 |
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| creator | Azzari, Chiara Cortimiglia, Martina Nieddu, Francesco Moriondo, Maria Indolfi, Giuseppe Mattei, Romano Zuliani, Massimo Adriani, Beatrice Degl'Innocenti, Roberto Consales, Guglielmo Aquilini, Donatella Bini, Giancarlo Di Natale, Massimo Edoardo Canessa, Clementina Ricci, Silvia de Vitis, Elisa Mangone, Giusi Bechini, Angela Bonanni, Paolo Pasinato, Angela Resti, Massimo |
| description | The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas. Two hundred twenty-one patients (116 males, median 67.9 years) with IPD were studied (pneumonia n = 103, meningitis n = 61 sepsis n = 50, other n = 7). Two hundred twelve were serotyped. The most frequent serotypes were 3, (31/212; 14.6%), 19A, (19/212; 9.0%), 12 (17/212; 8.0%), 7F, (14/212; 6.6%). In NP of children, the frequency of those serotypes causing over 50% of IPD in adults was very low, ranging from 0.48% for serotype 7F to 7.9% for serotype 19A. On the other side serotype 5, very frequent in NP (18.7%) caused |
| doi_str_mv | 10.1080/21645515.2015.1102811 |
| format | Article |
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It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas. Two hundred twenty-one patients (116 males, median 67.9 years) with IPD were studied (pneumonia n = 103, meningitis n = 61 sepsis n = 50, other n = 7). Two hundred twelve were serotyped. The most frequent serotypes were 3, (31/212; 14.6%), 19A, (19/212; 9.0%), 12 (17/212; 8.0%), 7F, (14/212; 6.6%). In NP of children, the frequency of those serotypes causing over 50% of IPD in adults was very low, ranging from 0.48% for serotype 7F to 7.9% for serotype 19A. On the other side serotype 5, very frequent in NP (18.7%) caused <1% IPD. In conclusion serotypes causing IPD in adults are very rarely found in children NP. We suggest that herd protection obtainable with the additional 6 serotypes included in PCV13 may be more limited than that demonstrated with PCV7 in the past. In order to reduce the burden of disease in adults, adults should be offered a specific vaccination program with highly immunogenic PCV.</description><identifier>ISSN: 2164-5515</identifier><identifier>EISSN: 2164-554X</identifier><identifier>DOI: 10.1080/21645515.2015.1102811</identifier><identifier>PMID: 26647277</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Adult ; Aged ; Carrier State - microbiology ; Carrier State - prevention & control ; Child ; Child, Preschool ; Heptavalent Pneumococcal Conjugate Vaccine - immunology ; herd-protection ; Humans ; Immunity, Herd - immunology ; Immunization Programs ; invasive pneumococcal disease ; Italy ; Middle Aged ; nasopharyngeal carriage ; Nasopharynx - microbiology ; pneumococcal serotype ; Pneumococcal Vaccines - immunology ; Pneumonia, Pneumococcal - immunology ; Pneumonia, Pneumococcal - microbiology ; Pneumonia, Pneumococcal - prevention & control ; Realtime PCR ; Research Paper ; Serogroup ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - immunology ; Vaccination ; vaccine ; Vaccines, Conjugate - immunology</subject><ispartof>Human vaccines & immunotherapeutics, 2016-02, Vol.12 (2), p.344-350</ispartof><rights>2016 The Author(s). Published with license by Taylor & Francis Group, LLC © Chiara Azzari, Martina Cortimiglia, Francesco Nieddu, Maria Moriondo, Giuseppe Indolfi, Romano Mattei, Massimo Zuliani, Beatrice Adriani, Roberto Degl'Innocenti, Guglielmo Consales, Donatella Aquilini, Giancarlo Bini, Massimo Edoardo Di Natale, Clementina Canessa, Silvia Ricci, Elisa de Vitis, Giusi Mangone, Angela Bechini, Paolo Bonanni, Angela Pasinato, and Massimo Resti 2016</rights><rights>2016 The Author(s). Published with license by Taylor & Francis Group, LLC 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-8aac2053be8ca19e25e4b0ea8d302592dee870c89f1e2a7893306feedfba7b1b3</citedby><cites>FETCH-LOGICAL-c468t-8aac2053be8ca19e25e4b0ea8d302592dee870c89f1e2a7893306feedfba7b1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049737/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049737/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26647277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azzari, Chiara</creatorcontrib><creatorcontrib>Cortimiglia, Martina</creatorcontrib><creatorcontrib>Nieddu, Francesco</creatorcontrib><creatorcontrib>Moriondo, Maria</creatorcontrib><creatorcontrib>Indolfi, Giuseppe</creatorcontrib><creatorcontrib>Mattei, Romano</creatorcontrib><creatorcontrib>Zuliani, Massimo</creatorcontrib><creatorcontrib>Adriani, Beatrice</creatorcontrib><creatorcontrib>Degl'Innocenti, Roberto</creatorcontrib><creatorcontrib>Consales, Guglielmo</creatorcontrib><creatorcontrib>Aquilini, Donatella</creatorcontrib><creatorcontrib>Bini, Giancarlo</creatorcontrib><creatorcontrib>Di Natale, Massimo Edoardo</creatorcontrib><creatorcontrib>Canessa, Clementina</creatorcontrib><creatorcontrib>Ricci, Silvia</creatorcontrib><creatorcontrib>de Vitis, Elisa</creatorcontrib><creatorcontrib>Mangone, Giusi</creatorcontrib><creatorcontrib>Bechini, Angela</creatorcontrib><creatorcontrib>Bonanni, Paolo</creatorcontrib><creatorcontrib>Pasinato, Angela</creatorcontrib><creatorcontrib>Resti, Massimo</creatorcontrib><title>Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?</title><title>Human vaccines & immunotherapeutics</title><addtitle>Hum Vaccin Immunother</addtitle><description>The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas. Two hundred twenty-one patients (116 males, median 67.9 years) with IPD were studied (pneumonia n = 103, meningitis n = 61 sepsis n = 50, other n = 7). Two hundred twelve were serotyped. The most frequent serotypes were 3, (31/212; 14.6%), 19A, (19/212; 9.0%), 12 (17/212; 8.0%), 7F, (14/212; 6.6%). In NP of children, the frequency of those serotypes causing over 50% of IPD in adults was very low, ranging from 0.48% for serotype 7F to 7.9% for serotype 19A. On the other side serotype 5, very frequent in NP (18.7%) caused <1% IPD. In conclusion serotypes causing IPD in adults are very rarely found in children NP. We suggest that herd protection obtainable with the additional 6 serotypes included in PCV13 may be more limited than that demonstrated with PCV7 in the past. In order to reduce the burden of disease in adults, adults should be offered a specific vaccination program with highly immunogenic PCV.</description><subject>Adult</subject><subject>Aged</subject><subject>Carrier State - microbiology</subject><subject>Carrier State - prevention & control</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Heptavalent Pneumococcal Conjugate Vaccine - immunology</subject><subject>herd-protection</subject><subject>Humans</subject><subject>Immunity, Herd - immunology</subject><subject>Immunization Programs</subject><subject>invasive pneumococcal disease</subject><subject>Italy</subject><subject>Middle Aged</subject><subject>nasopharyngeal carriage</subject><subject>Nasopharynx - microbiology</subject><subject>pneumococcal serotype</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Pneumonia, Pneumococcal - immunology</subject><subject>Pneumonia, Pneumococcal - microbiology</subject><subject>Pneumonia, Pneumococcal - prevention & control</subject><subject>Realtime PCR</subject><subject>Research Paper</subject><subject>Serogroup</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Vaccination</subject><subject>vaccine</subject><subject>Vaccines, Conjugate - immunology</subject><issn>2164-5515</issn><issn>2164-554X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEolXpI4C8g820thPHCQsoqqBUqgQSILGzbuybxsiJg-3MMA_FO5J0fgQbvLB97e_cY_lk2XNGLxit6CVnZSEEExeczhNjlFeMPcpOl_OVEMX3x8c9EyfZeYw_6Dwk5UVZPs1OeFkWkkt5mv3-PODUe-21BkciBp-2IxJjYwq2mZL1A7EDATO5FMnGpm4u1xDt-gFCiEhgMAujIQSLgejOOhPwQXebwG1fky-dn5whGyT4a0SdSIfBkHE2m4vFwrcHi9QFP90vLi0MKb4ka9DaDrBgb59lT1pwEc_361n27cP7r9cfV3efbm6v392tdFFWaVUBaE5F3mClgdXIBRYNRahMTrmouUGsJNVV3TLkIKs6z2nZIpq2AdmwJj_L3uz6jlPTo9E4pABOjcH2ELbKg1X_3gy2U_d-rQQtapnLucGrfYPgf04Yk-pt1OgcDOinqJgsK1bWvMhnVOxQHXyMAdujDaNqSVsd0lZL2mqf9qx78fcbj6pDtjNwtQPmr_Shh40PzqgEW-dDG2DQNqr8_x5_ANbXv6E</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Azzari, Chiara</creator><creator>Cortimiglia, Martina</creator><creator>Nieddu, Francesco</creator><creator>Moriondo, Maria</creator><creator>Indolfi, Giuseppe</creator><creator>Mattei, Romano</creator><creator>Zuliani, Massimo</creator><creator>Adriani, Beatrice</creator><creator>Degl'Innocenti, Roberto</creator><creator>Consales, Guglielmo</creator><creator>Aquilini, Donatella</creator><creator>Bini, Giancarlo</creator><creator>Di Natale, Massimo Edoardo</creator><creator>Canessa, Clementina</creator><creator>Ricci, Silvia</creator><creator>de Vitis, Elisa</creator><creator>Mangone, Giusi</creator><creator>Bechini, Angela</creator><creator>Bonanni, Paolo</creator><creator>Pasinato, Angela</creator><creator>Resti, Massimo</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?</title><author>Azzari, Chiara ; Cortimiglia, Martina ; Nieddu, Francesco ; Moriondo, Maria ; Indolfi, Giuseppe ; Mattei, Romano ; Zuliani, Massimo ; Adriani, Beatrice ; Degl'Innocenti, Roberto ; Consales, Guglielmo ; Aquilini, Donatella ; Bini, Giancarlo ; Di Natale, Massimo Edoardo ; Canessa, Clementina ; Ricci, Silvia ; de Vitis, Elisa ; Mangone, Giusi ; Bechini, Angela ; Bonanni, Paolo ; Pasinato, Angela ; Resti, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-8aac2053be8ca19e25e4b0ea8d302592dee870c89f1e2a7893306feedfba7b1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carrier State - microbiology</topic><topic>Carrier State - prevention & control</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Heptavalent Pneumococcal Conjugate Vaccine - immunology</topic><topic>herd-protection</topic><topic>Humans</topic><topic>Immunity, Herd - immunology</topic><topic>Immunization Programs</topic><topic>invasive pneumococcal disease</topic><topic>Italy</topic><topic>Middle Aged</topic><topic>nasopharyngeal carriage</topic><topic>Nasopharynx - microbiology</topic><topic>pneumococcal serotype</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Pneumonia, Pneumococcal - immunology</topic><topic>Pneumonia, Pneumococcal - microbiology</topic><topic>Pneumonia, Pneumococcal - prevention & control</topic><topic>Realtime PCR</topic><topic>Research Paper</topic><topic>Serogroup</topic><topic>Streptococcus pneumoniae - classification</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Vaccination</topic><topic>vaccine</topic><topic>Vaccines, Conjugate - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azzari, Chiara</creatorcontrib><creatorcontrib>Cortimiglia, Martina</creatorcontrib><creatorcontrib>Nieddu, Francesco</creatorcontrib><creatorcontrib>Moriondo, Maria</creatorcontrib><creatorcontrib>Indolfi, Giuseppe</creatorcontrib><creatorcontrib>Mattei, Romano</creatorcontrib><creatorcontrib>Zuliani, Massimo</creatorcontrib><creatorcontrib>Adriani, Beatrice</creatorcontrib><creatorcontrib>Degl'Innocenti, Roberto</creatorcontrib><creatorcontrib>Consales, Guglielmo</creatorcontrib><creatorcontrib>Aquilini, Donatella</creatorcontrib><creatorcontrib>Bini, Giancarlo</creatorcontrib><creatorcontrib>Di Natale, Massimo Edoardo</creatorcontrib><creatorcontrib>Canessa, Clementina</creatorcontrib><creatorcontrib>Ricci, Silvia</creatorcontrib><creatorcontrib>de Vitis, Elisa</creatorcontrib><creatorcontrib>Mangone, Giusi</creatorcontrib><creatorcontrib>Bechini, Angela</creatorcontrib><creatorcontrib>Bonanni, Paolo</creatorcontrib><creatorcontrib>Pasinato, Angela</creatorcontrib><creatorcontrib>Resti, Massimo</creatorcontrib><collection>Taylor & Francis Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human vaccines & immunotherapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azzari, Chiara</au><au>Cortimiglia, Martina</au><au>Nieddu, Francesco</au><au>Moriondo, Maria</au><au>Indolfi, Giuseppe</au><au>Mattei, Romano</au><au>Zuliani, Massimo</au><au>Adriani, Beatrice</au><au>Degl'Innocenti, Roberto</au><au>Consales, Guglielmo</au><au>Aquilini, Donatella</au><au>Bini, Giancarlo</au><au>Di Natale, Massimo Edoardo</au><au>Canessa, Clementina</au><au>Ricci, Silvia</au><au>de Vitis, Elisa</au><au>Mangone, Giusi</au><au>Bechini, Angela</au><au>Bonanni, Paolo</au><au>Pasinato, Angela</au><au>Resti, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?</atitle><jtitle>Human vaccines & immunotherapeutics</jtitle><addtitle>Hum Vaccin Immunother</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>12</volume><issue>2</issue><spage>344</spage><epage>350</epage><pages>344-350</pages><issn>2164-5515</issn><eissn>2164-554X</eissn><abstract>The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas. Two hundred twenty-one patients (116 males, median 67.9 years) with IPD were studied (pneumonia n = 103, meningitis n = 61 sepsis n = 50, other n = 7). Two hundred twelve were serotyped. The most frequent serotypes were 3, (31/212; 14.6%), 19A, (19/212; 9.0%), 12 (17/212; 8.0%), 7F, (14/212; 6.6%). In NP of children, the frequency of those serotypes causing over 50% of IPD in adults was very low, ranging from 0.48% for serotype 7F to 7.9% for serotype 19A. On the other side serotype 5, very frequent in NP (18.7%) caused <1% IPD. In conclusion serotypes causing IPD in adults are very rarely found in children NP. We suggest that herd protection obtainable with the additional 6 serotypes included in PCV13 may be more limited than that demonstrated with PCV7 in the past. In order to reduce the burden of disease in adults, adults should be offered a specific vaccination program with highly immunogenic PCV.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>26647277</pmid><doi>10.1080/21645515.2015.1102811</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Carrier State - microbiology Carrier State - prevention & control Child Child, Preschool Heptavalent Pneumococcal Conjugate Vaccine - immunology herd-protection Humans Immunity, Herd - immunology Immunization Programs invasive pneumococcal disease Italy Middle Aged nasopharyngeal carriage Nasopharynx - microbiology pneumococcal serotype Pneumococcal Vaccines - immunology Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - prevention & control Realtime PCR Research Paper Serogroup Streptococcus pneumoniae - classification Streptococcus pneumoniae - immunology Vaccination vaccine Vaccines, Conjugate - immunology |
| title | Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination? |
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