The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

The advent of modern C-H functionalization chemistries has enabled medicinal chemists to consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C-H bonds of drug leads as points of diversification for generating new analogs. LSF approaches offer the promise of rapid ex...

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Veröffentlicht in:	Chemical Society reviews 2016-02, Vol.45 (3), p.546-576
Hauptverfasser:	Cernak, Tim, Dykstra, Kevin D, Tyagarajan, Sriram, Vachal, Petr, Krska, Shane W
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioactive Biology Blocking Chemists Drugs Hot spots Strategy
Online-Zugang:	Volltext
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