Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Context: Metformin hydrochloride is a biguanide derivative widely used for the treatment of type 2 diabetes, prescribed nearly to 120 million people worldwide. Metformin has a relatively low oral bioavailability (about 50-60%). Although the major effect of metformin is to decrease hepatic glucose ou...

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Veröffentlicht in:	Drug delivery 2016-10, Vol.23 (8), p.2796-2805
Hauptverfasser:	Cetin, Meltem, Sahin, Selma
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Chemistry, Pharmaceutical - methods diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Drug Delivery Systems - methods Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Metformin - administration & dosage Metformin - chemistry metformin hydrochloride microparticles nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry
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