ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes
Aim: Recent meta-analyses of the literature confirmed the association between the RR+RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athletic status in Europeans but not in Asians and Africans, while the association between the R577X genotype and elite endurance athlete status is...
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| Veröffentlicht in: | European journal of sport science 2016-09, Vol.16 (6), p.694-701 |
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| creator | Kikuchi, Naoki Miyamoto-Mikami, Eri Murakami, Haruka Nakamura, Tomohiro Min, Seok-Ki Mizuno, Masuhiko Naito, Hisashi Miyachi, Motohiko Nakazato, Koichi Fuku, Noriyuki |
| description | Aim: Recent meta-analyses of the literature confirmed the association between the RR+RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athletic status in Europeans but not in Asians and Africans, while the association between the R577X genotype and elite endurance athlete status is less convincing. The aim of the present study was to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. Methods: One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls were genotyped for the ACTN3 R577X polymorphism (rs1815739) by using the TaqMan® SNP Genotyping Assay. Results: Elite sprint/power athletes had a higher frequency of the RR+RX genotype than the controls (OR: 1.59, 95% CI: 1.16-2.18; P = .003). A significant linear correlation was found between the RR + RX genotype and athlete status (i.e. regional |
| doi_str_mv | 10.1080/17461391.2015.1071879 |
| format | Article |
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The aim of the present study was to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. Methods: One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls were genotyped for the ACTN3 R577X polymorphism (rs1815739) by using the TaqMan® SNP Genotyping Assay. Results: Elite sprint/power athletes had a higher frequency of the RR+RX genotype than the controls (OR: 1.59, 95% CI: 1.16-2.18; P = .003). A significant linear correlation was found between the RR + RX genotype and athlete status (i.e. regional < national < international) in sprint/power athletes (regional: 71%, national: 81%, international: 84%; P = .001 for trend) and long-distance runners (regional: 65%, national: 72%, international: 82%; P = .030 for trend). Conclusions: The data obtained for this large Asian (Japanese) cohort of track and field athletes served to confirm the association between the RR + RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athlete status and also the association between the ACTN3 RR + RX genotype and long-distance running athletic status.</description><identifier>ISSN: 1746-1391</identifier><identifier>EISSN: 1536-7290</identifier><identifier>DOI: 10.1080/17461391.2015.1071879</identifier><identifier>PMID: 26324221</identifier><language>eng</language><publisher>England: Routledge</publisher><subject>Actinin - genetics ; Asian ; Asian Continental Ancestry Group - genetics ; Asian Continental Ancestry Group - statistics & numerical data ; Athletes - statistics & numerical data ; Athletic Performance - statistics & numerical data ; endurance ; Genotype ; Humans ; Japan ; physical performance ; polymorphism ; Polymorphism, Single Nucleotide - genetics ; Sprint/power ; Track and Field</subject><ispartof>European journal of sport science, 2016-09, Vol.16 (6), p.694-701</ispartof><rights>2015 European College of Sport Science 2015</rights><rights>European College of Sport Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5206-c5950c24da8a5d78c2600653c90191be99290d8b085da9247142fe75b5a62ce3</citedby><cites>FETCH-LOGICAL-c5206-c5950c24da8a5d78c2600653c90191be99290d8b085da9247142fe75b5a62ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/17461391.2015.1071879$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/17461391.2015.1071879$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26324221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kikuchi, Naoki</creatorcontrib><creatorcontrib>Miyamoto-Mikami, Eri</creatorcontrib><creatorcontrib>Murakami, Haruka</creatorcontrib><creatorcontrib>Nakamura, Tomohiro</creatorcontrib><creatorcontrib>Min, Seok-Ki</creatorcontrib><creatorcontrib>Mizuno, Masuhiko</creatorcontrib><creatorcontrib>Naito, Hisashi</creatorcontrib><creatorcontrib>Miyachi, Motohiko</creatorcontrib><creatorcontrib>Nakazato, Koichi</creatorcontrib><creatorcontrib>Fuku, Noriyuki</creatorcontrib><title>ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes</title><title>European journal of sport science</title><addtitle>Eur J Sport Sci</addtitle><description>Aim: Recent meta-analyses of the literature confirmed the association between the RR+RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athletic status in Europeans but not in Asians and Africans, while the association between the R577X genotype and elite endurance athlete status is less convincing. The aim of the present study was to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. Methods: One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls were genotyped for the ACTN3 R577X polymorphism (rs1815739) by using the TaqMan® SNP Genotyping Assay. Results: Elite sprint/power athletes had a higher frequency of the RR+RX genotype than the controls (OR: 1.59, 95% CI: 1.16-2.18; P = .003). A significant linear correlation was found between the RR + RX genotype and athlete status (i.e. regional < national < international) in sprint/power athletes (regional: 71%, national: 81%, international: 84%; P = .001 for trend) and long-distance runners (regional: 65%, national: 72%, international: 82%; P = .030 for trend). Conclusions: The data obtained for this large Asian (Japanese) cohort of track and field athletes served to confirm the association between the RR + RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athlete status and also the association between the ACTN3 RR + RX genotype and long-distance running athletic status.</description><subject>Actinin - genetics</subject><subject>Asian</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Athletes - statistics & numerical data</subject><subject>Athletic Performance - statistics & numerical data</subject><subject>endurance</subject><subject>Genotype</subject><subject>Humans</subject><subject>Japan</subject><subject>physical performance</subject><subject>polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Sprint/power</subject><subject>Track and Field</subject><issn>1746-1391</issn><issn>1536-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu2zAQRYmiRd6f0IDLbuwOKfG1KeIYTlojSIHWi-4ImholKmRRIWUY_vvQsZNlmw1JDM69M7xDyGcGYwYavjJVSlYYNubARC4pppX5QE6YKORIcQMf8zszox10TE5T-guQC1wfkWMuC15yzk7IYjJd3Bf0l1DqD33ALgzbHqnrKuqGxxaHxtMeYx3iynUeadNRR1sXH5D68BjiQENN5653HSY8SDCdk0-1axNeHO4zsriZLabfR3c_b39MJ3cjLzjIfBoBnpeV005USnsuAaQovAFm2BKNyd-o9BK0qJzhpWIlr1GJpXCSeyzOyJe9bR_D0xrTYFdN8ti2eZqwTpZp0FJIyYv_o8qYTEouMir2qI8hpYi17WOzcnFrGdhd9PY1eruL3h6iz7rLQ4v1coXVm-o16wx82wObpsXt-1ztbP57en0DoI3MBld7g6Z7WcgmxLayg9u2IdYx76dJtvj3kM-WqKFN</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Kikuchi, Naoki</creator><creator>Miyamoto-Mikami, Eri</creator><creator>Murakami, Haruka</creator><creator>Nakamura, Tomohiro</creator><creator>Min, Seok-Ki</creator><creator>Mizuno, Masuhiko</creator><creator>Naito, Hisashi</creator><creator>Miyachi, Motohiko</creator><creator>Nakazato, Koichi</creator><creator>Fuku, Noriyuki</creator><general>Routledge</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>201609</creationdate><title>ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes</title><author>Kikuchi, Naoki ; Miyamoto-Mikami, Eri ; Murakami, Haruka ; Nakamura, Tomohiro ; Min, Seok-Ki ; Mizuno, Masuhiko ; Naito, Hisashi ; Miyachi, Motohiko ; Nakazato, Koichi ; Fuku, Noriyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5206-c5950c24da8a5d78c2600653c90191be99290d8b085da9247142fe75b5a62ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Actinin - genetics</topic><topic>Asian</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Athletes - statistics & numerical data</topic><topic>Athletic Performance - statistics & numerical data</topic><topic>endurance</topic><topic>Genotype</topic><topic>Humans</topic><topic>Japan</topic><topic>physical performance</topic><topic>polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Sprint/power</topic><topic>Track and Field</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikuchi, Naoki</creatorcontrib><creatorcontrib>Miyamoto-Mikami, Eri</creatorcontrib><creatorcontrib>Murakami, Haruka</creatorcontrib><creatorcontrib>Nakamura, Tomohiro</creatorcontrib><creatorcontrib>Min, Seok-Ki</creatorcontrib><creatorcontrib>Mizuno, Masuhiko</creatorcontrib><creatorcontrib>Naito, Hisashi</creatorcontrib><creatorcontrib>Miyachi, Motohiko</creatorcontrib><creatorcontrib>Nakazato, Koichi</creatorcontrib><creatorcontrib>Fuku, Noriyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>European journal of sport science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kikuchi, Naoki</au><au>Miyamoto-Mikami, Eri</au><au>Murakami, Haruka</au><au>Nakamura, Tomohiro</au><au>Min, Seok-Ki</au><au>Mizuno, Masuhiko</au><au>Naito, Hisashi</au><au>Miyachi, Motohiko</au><au>Nakazato, Koichi</au><au>Fuku, Noriyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes</atitle><jtitle>European journal of sport science</jtitle><addtitle>Eur J Sport Sci</addtitle><date>2016-09</date><risdate>2016</risdate><volume>16</volume><issue>6</issue><spage>694</spage><epage>701</epage><pages>694-701</pages><issn>1746-1391</issn><eissn>1536-7290</eissn><abstract>Aim: Recent meta-analyses of the literature confirmed the association between the RR+RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athletic status in Europeans but not in Asians and Africans, while the association between the R577X genotype and elite endurance athlete status is less convincing. The aim of the present study was to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. Methods: One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls were genotyped for the ACTN3 R577X polymorphism (rs1815739) by using the TaqMan® SNP Genotyping Assay. Results: Elite sprint/power athletes had a higher frequency of the RR+RX genotype than the controls (OR: 1.59, 95% CI: 1.16-2.18; P = .003). A significant linear correlation was found between the RR + RX genotype and athlete status (i.e. regional < national < international) in sprint/power athletes (regional: 71%, national: 81%, international: 84%; P = .001 for trend) and long-distance runners (regional: 65%, national: 72%, international: 82%; P = .030 for trend). Conclusions: The data obtained for this large Asian (Japanese) cohort of track and field athletes served to confirm the association between the RR + RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athlete status and also the association between the ACTN3 RR + RX genotype and long-distance running athletic status.</abstract><cop>England</cop><pub>Routledge</pub><pmid>26324221</pmid><doi>10.1080/17461391.2015.1071879</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of sport science, 2016-09, Vol.16 (6), p.694-701 |
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| source | MEDLINE; Taylor & Francis Journals Complete; Alma/SFX Local Collection |
| subjects | Actinin - genetics Asian Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - statistics & numerical data Athletes - statistics & numerical data Athletic Performance - statistics & numerical data endurance Genotype Humans Japan physical performance polymorphism Polymorphism, Single Nucleotide - genetics Sprint/power Track and Field |
| title | ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes |
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