Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

Sphingolipid metabolism has been identified as a potential therapeutic target in cancer. Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid metabolite produced by sphingosine kinases-1 and −2 (SPHK1 and SPHK2). Elevated SPHK1 has been found in numerous cancer types and been shown to co...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer biology & therapy 2015-12, Vol.16 (12), p.1830-1840
Hauptverfasser:	LeBlanc, Francis R, Liu, Xin, Hengst, Jeremy, Fox, Todd, Calvert, Valerie, Petricoin, Emanuel F, Yun, Jong, Feith, David J, Loughran, Thomas P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Caspases - metabolism Cell Survival - drug effects Enzyme Inhibitors - pharmacology G2 Phase Cell Cycle Checkpoints - drug effects Gene Expression Humans Hydrazines - pharmacology Janus Kinases - metabolism JNK Mitogen-Activated Protein Kinases - metabolism large granular lymphocyte Leukemia, Large Granular Lymphocytic - genetics Leukemia, Large Granular Lymphocytic - metabolism LGL leukemia Mitochondria - drug effects Mitochondria - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism natural killer p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrazoles - pharmacology Research Paper Signal Transduction SKI-178,SKI-II Sphingolipids - metabolism sphingosine kinase 1 STAT Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!