Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

Tripartite motif (TRIM) 21 is a cytosolic antibody receptor that neutralizes antibody-coated viruses that penetrate the cell and simultaneously activates innate immunity. Here we show that the conjugation of TRIM21 with K63-linked ubiquitin (Ub-63Ub) catalyzed by the sequential activity of nonredund...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-08, Vol.112 (32), p.10014-10019
Hauptverfasser:	Fletcher, Adam J., Mallery, Donna L., Watkinson, Ruth E., Dickson, Claire F., James, Leo C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Catalysis Cell Line Cytokines Cytokines - genetics Enzymes Humans Lysine - metabolism Mice Models, Biological Neutralization Neutralization Tests NF-kappa B - metabolism Polyubiquitin - metabolism Proteasome Endopeptidase Complex - metabolism Ribonucleoproteins - metabolism Sensors Signal Transduction Substrate Specificity Trans-Activators - metabolism Transcription, Genetic Ubiquitin-Conjugating Enzymes - metabolism Ubiquitination
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