Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness

Diastolic dysfunction in heart failure patients is evident from stiffening of the passive properties of the ventricular wall. Increased actomyosin interactions may significantly limit diastolic capacity, however, direct evidence is absent. From experiments at the cellular and whole organ level, in h...

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Veröffentlicht in:	The Journal of physiology 2015-09, Vol.593 (17), p.3899
Hauptverfasser:	Sequeira, Vasco, Najafi, Aref, McConnell, Mark, Fowler, Ewan D, Bollen, Ilse A E, Wüst, Rob C I, dos Remedios, Cris, Helmes, Michiel, White, Ed, Stienen, Ger J M, Tardiff, Jil, Kuster, Diederik W D, van der Velden, Jolanda
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin - physiology Adenosine Diphosphate - physiology Animals Calcium - physiology Cardiomyopathy, Dilated - physiopathology Creatine Kinase - antagonists & inhibitors Creatine Kinase - physiology Diastole Heart - physiology Humans Iodoacetamide - pharmacology Isometric Contraction Male Myocytes, Cardiac - physiology Rats, Wistar
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