Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway

Background: Berberine, a well-known component of the Chinese herbal medicine Huanglian, has wide range of biochemical and pharmacological effects, including antineoplastic effect, but the exact mechanisms remain unclear. The aim of the present study was to evaluate the potential chemo-sensitization...

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Veröffentlicht in:	Cellular physiology and biochemistry 2015-01, Vol.36 (3), p.956-965
Hauptverfasser:	Chen, Qiaoyun, Qin, Rong, Fang, Yue, Li, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Berberine Berberine - pharmacology Cell Line, Tumor Cisplatin Cisplatin - pharmacology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Drug Synergism Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Female G1 Phase Cell Cycle Checkpoints - drug effects Gene Expression Regulation, Neoplastic Genes, Reporter Humans Luciferases - genetics Luciferases - metabolism MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miR-93 Original Paper Ovarian cancer cells Ovary - drug effects Ovary - metabolism Ovary - pathology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - agonists PTEN Phosphohydrolase - antagonists & inhibitors PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Ribonucleosides - pharmacology RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction
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