Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum

The identification of new pathways governing myelination provides innovative avenues for remyelination. Liver X receptors (LXRs) α and β are nuclear receptors activated by oxysterols that originated from the oxidation of cholesterol. They are crucial for cholesterol homeostasis, amajor lipid constit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-06, Vol.112 (24), p.7587-7592
Hauptverfasser:	Meffre, Delphine, Shackleford, Ghjuvan’Ghjacumu, Hichor, Mehdi, Gorgievski, Victor, Tzavara, Eleni T., Trousson, Amalia, Ghoumari, Abdel M., Deboux, Cyrille, Oumesmar, Brahim Nait, Liere, Philippe, Schumacher, Michael, Baulieu, Etienne-Emile, Charbonnier, Frédéric, Grenier, Julien, Massaad, Charbel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell Differentiation - drug effects cerebellum Cerebellum - cytology Cerebellum - drug effects Cerebellum - physiology Cholesterol Cholesterol - metabolism Gene expression Gene Expression Regulation - drug effects Homeostasis Hydrocarbons, Fluorinated - pharmacology Hydroxycholesterols - pharmacology learning Life Sciences liver Liver X Receptors Male Mice Mice, Knockout myelin proteins myelin sheath Myelin Sheath - drug effects Myelin Sheath - genetics Myelin Sheath - physiology myelination Neurons and Cognition oligodendroglia Oligodendroglia - cytology Oligodendroglia - drug effects Oligodendroglia - metabolism Organ Culture Techniques Orphan Nuclear Receptors - agonists Orphan Nuclear Receptors - deficiency Orphan Nuclear Receptors - physiology Oxidation Promoter Regions, Genetic Proteins Psychomotor Performance - drug effects Psychomotor Performance - physiology receptors Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Spatial Learning - drug effects Spatial Learning - physiology Sulfonamides - pharmacology transcription (genetics)
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