Optimal flushing agents for integrated optical and acoustic imaging systems
An increasing number of integrated optical and acoustic intravascular imaging systems have been developed and hold great promise for accurately diagnosing vulnerable plaques and guiding atherosclerosis treatment. However, in any intravascular environment, the vascular lumen is filled with blood, a h...
Gespeichert in:
| Veröffentlicht in: | Journal of biomedical optics 2015-05, Vol.20 (5), p.056005-056005 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 056005 |
|---|---|
| container_issue | 5 |
| container_start_page | 056005 |
| container_title | Journal of biomedical optics |
| container_volume | 20 |
| creator | Li, Jiawen Minami, Hataka Steward, Earl Ma, Teng Mohar, Dilbahar Robertson, Claire Shung, Kirk Zhou, Qifa Patel, Pranav Chen, Zhongping |
| description | An increasing number of integrated optical and acoustic intravascular imaging systems have been developed and hold great promise for accurately diagnosing vulnerable plaques and guiding atherosclerosis treatment. However, in any intravascular environment, the vascular lumen is filled with blood, a high-scattering source for optical and high-frequency ultrasound signals. Blood must be flushed away to provide clearer images. To our knowledge, no research has been performed to find the ideal flushing agent for combined optical and acoustic imaging techniques. We selected three solutions as potential flushing agents for their image-enhancing effects: mannitol, dextran, and iohexol. Testing of these flushing agents was performed in a closed-loop circulation model and in vivo on rabbits. We found that a high concentration of dextran was the most useful for simultaneous intravascular ultrasound and optical coherence tomography imaging. |
| doi_str_mv | 10.1117/1.JBO.20.5.056005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_25985096</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1682204110</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-d62b7eea68cbb7a638a5cbfe8d2339fa4a090ea03ed72a25bb1dc5210f76e7fa3</originalsourceid><addsrcrecordid>eNp1kc1O3TAQhS1UVCjtA3RTZdlNwtiJHWdTidJSCki3C7q2HGccgnKT1E6Q6NN34AKFQlf-mXM-H88w9p5Dxjkv93l28nmVCchkBlIByC22y2mTCqH5K9qDztNcKb3D3sR4CQBaVeo12xGy0hIqtctOV9PcrW2f-H6JF93QJrbFYY6JH0PSDTO2wc7YJCPJHMns0CTWjUukY0LG9sYSr-OM6_iWbXvbR3x3t-6xn0dfzw-P07PVt--HB2epk1zOaaNEXSJapV1dl1bl2kpXe9SNyPPK28JCBWghx6YUVsi65o2TgoMvFZbe5nvs04Y7LfUaG0d5g-3NFChPuDaj7czTytBdmHa8MkWRS1EIAny8A4Tx14JxNusuOux7OyB9zXClhYCCcyAp30hdGGMM6B-e4WBuhmC4oSEYAUaazRDI8-FxvgfHfddJcL4RxKlDczkuYaB-_eX87qZ_obd3B4G63uOPL0fPylPjCZu9hP1_0D9L1q8X</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1682204110</pqid></control><display><type>article</type><title>Optimal flushing agents for integrated optical and acoustic imaging systems</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Li, Jiawen ; Minami, Hataka ; Steward, Earl ; Ma, Teng ; Mohar, Dilbahar ; Robertson, Claire ; Shung, Kirk ; Zhou, Qifa ; Patel, Pranav ; Chen, Zhongping</creator><creatorcontrib>Li, Jiawen ; Minami, Hataka ; Steward, Earl ; Ma, Teng ; Mohar, Dilbahar ; Robertson, Claire ; Shung, Kirk ; Zhou, Qifa ; Patel, Pranav ; Chen, Zhongping</creatorcontrib><description>An increasing number of integrated optical and acoustic intravascular imaging systems have been developed and hold great promise for accurately diagnosing vulnerable plaques and guiding atherosclerosis treatment. However, in any intravascular environment, the vascular lumen is filled with blood, a high-scattering source for optical and high-frequency ultrasound signals. Blood must be flushed away to provide clearer images. To our knowledge, no research has been performed to find the ideal flushing agent for combined optical and acoustic imaging techniques. We selected three solutions as potential flushing agents for their image-enhancing effects: mannitol, dextran, and iohexol. Testing of these flushing agents was performed in a closed-loop circulation model and in vivo on rabbits. We found that a high concentration of dextran was the most useful for simultaneous intravascular ultrasound and optical coherence tomography imaging.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.JBO.20.5.056005</identifier><identifier>PMID: 25985096</identifier><language>eng</language><publisher>United States: Society of Photo-Optical Instrumentation Engineers</publisher><subject>Animals ; Contrast Media ; Coronary Vessels - anatomy & histology ; Coronary Vessels - diagnostic imaging ; Dextrans ; Image Enhancement - methods ; Iohexol ; Mannitol ; Rabbits ; Reproducibility of Results ; Research Papers: Imaging ; Sensitivity and Specificity ; Tomography, Optical Coherence - methods ; Ultrasonography, Interventional - methods</subject><ispartof>Journal of biomedical optics, 2015-05, Vol.20 (5), p.056005-056005</ispartof><rights>2015 Society of Photo-Optical Instrumentation Engineers (SPIE)</rights><rights>2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 2015 Society of Photo-Optical Instrumentation Engineers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-d62b7eea68cbb7a638a5cbfe8d2339fa4a090ea03ed72a25bb1dc5210f76e7fa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435242/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435242/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25985096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jiawen</creatorcontrib><creatorcontrib>Minami, Hataka</creatorcontrib><creatorcontrib>Steward, Earl</creatorcontrib><creatorcontrib>Ma, Teng</creatorcontrib><creatorcontrib>Mohar, Dilbahar</creatorcontrib><creatorcontrib>Robertson, Claire</creatorcontrib><creatorcontrib>Shung, Kirk</creatorcontrib><creatorcontrib>Zhou, Qifa</creatorcontrib><creatorcontrib>Patel, Pranav</creatorcontrib><creatorcontrib>Chen, Zhongping</creatorcontrib><title>Optimal flushing agents for integrated optical and acoustic imaging systems</title><title>Journal of biomedical optics</title><addtitle>J. Biomed. Opt</addtitle><description>An increasing number of integrated optical and acoustic intravascular imaging systems have been developed and hold great promise for accurately diagnosing vulnerable plaques and guiding atherosclerosis treatment. However, in any intravascular environment, the vascular lumen is filled with blood, a high-scattering source for optical and high-frequency ultrasound signals. Blood must be flushed away to provide clearer images. To our knowledge, no research has been performed to find the ideal flushing agent for combined optical and acoustic imaging techniques. We selected three solutions as potential flushing agents for their image-enhancing effects: mannitol, dextran, and iohexol. Testing of these flushing agents was performed in a closed-loop circulation model and in vivo on rabbits. We found that a high concentration of dextran was the most useful for simultaneous intravascular ultrasound and optical coherence tomography imaging.</description><subject>Animals</subject><subject>Contrast Media</subject><subject>Coronary Vessels - anatomy & histology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Dextrans</subject><subject>Image Enhancement - methods</subject><subject>Iohexol</subject><subject>Mannitol</subject><subject>Rabbits</subject><subject>Reproducibility of Results</subject><subject>Research Papers: Imaging</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Ultrasonography, Interventional - methods</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1O3TAQhS1UVCjtA3RTZdlNwtiJHWdTidJSCki3C7q2HGccgnKT1E6Q6NN34AKFQlf-mXM-H88w9p5Dxjkv93l28nmVCchkBlIByC22y2mTCqH5K9qDztNcKb3D3sR4CQBaVeo12xGy0hIqtctOV9PcrW2f-H6JF93QJrbFYY6JH0PSDTO2wc7YJCPJHMns0CTWjUukY0LG9sYSr-OM6_iWbXvbR3x3t-6xn0dfzw-P07PVt--HB2epk1zOaaNEXSJapV1dl1bl2kpXe9SNyPPK28JCBWghx6YUVsi65o2TgoMvFZbe5nvs04Y7LfUaG0d5g-3NFChPuDaj7czTytBdmHa8MkWRS1EIAny8A4Tx14JxNusuOux7OyB9zXClhYCCcyAp30hdGGMM6B-e4WBuhmC4oSEYAUaazRDI8-FxvgfHfddJcL4RxKlDczkuYaB-_eX87qZ_obd3B4G63uOPL0fPylPjCZu9hP1_0D9L1q8X</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Li, Jiawen</creator><creator>Minami, Hataka</creator><creator>Steward, Earl</creator><creator>Ma, Teng</creator><creator>Mohar, Dilbahar</creator><creator>Robertson, Claire</creator><creator>Shung, Kirk</creator><creator>Zhou, Qifa</creator><creator>Patel, Pranav</creator><creator>Chen, Zhongping</creator><general>Society of Photo-Optical Instrumentation Engineers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150501</creationdate><title>Optimal flushing agents for integrated optical and acoustic imaging systems</title><author>Li, Jiawen ; Minami, Hataka ; Steward, Earl ; Ma, Teng ; Mohar, Dilbahar ; Robertson, Claire ; Shung, Kirk ; Zhou, Qifa ; Patel, Pranav ; Chen, Zhongping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-d62b7eea68cbb7a638a5cbfe8d2339fa4a090ea03ed72a25bb1dc5210f76e7fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Contrast Media</topic><topic>Coronary Vessels - anatomy & histology</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Dextrans</topic><topic>Image Enhancement - methods</topic><topic>Iohexol</topic><topic>Mannitol</topic><topic>Rabbits</topic><topic>Reproducibility of Results</topic><topic>Research Papers: Imaging</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Ultrasonography, Interventional - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jiawen</creatorcontrib><creatorcontrib>Minami, Hataka</creatorcontrib><creatorcontrib>Steward, Earl</creatorcontrib><creatorcontrib>Ma, Teng</creatorcontrib><creatorcontrib>Mohar, Dilbahar</creatorcontrib><creatorcontrib>Robertson, Claire</creatorcontrib><creatorcontrib>Shung, Kirk</creatorcontrib><creatorcontrib>Zhou, Qifa</creatorcontrib><creatorcontrib>Patel, Pranav</creatorcontrib><creatorcontrib>Chen, Zhongping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jiawen</au><au>Minami, Hataka</au><au>Steward, Earl</au><au>Ma, Teng</au><au>Mohar, Dilbahar</au><au>Robertson, Claire</au><au>Shung, Kirk</au><au>Zhou, Qifa</au><au>Patel, Pranav</au><au>Chen, Zhongping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimal flushing agents for integrated optical and acoustic imaging systems</atitle><jtitle>Journal of biomedical optics</jtitle><addtitle>J. Biomed. Opt</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>20</volume><issue>5</issue><spage>056005</spage><epage>056005</epage><pages>056005-056005</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><abstract>An increasing number of integrated optical and acoustic intravascular imaging systems have been developed and hold great promise for accurately diagnosing vulnerable plaques and guiding atherosclerosis treatment. However, in any intravascular environment, the vascular lumen is filled with blood, a high-scattering source for optical and high-frequency ultrasound signals. Blood must be flushed away to provide clearer images. To our knowledge, no research has been performed to find the ideal flushing agent for combined optical and acoustic imaging techniques. We selected three solutions as potential flushing agents for their image-enhancing effects: mannitol, dextran, and iohexol. Testing of these flushing agents was performed in a closed-loop circulation model and in vivo on rabbits. We found that a high concentration of dextran was the most useful for simultaneous intravascular ultrasound and optical coherence tomography imaging.</abstract><cop>United States</cop><pub>Society of Photo-Optical Instrumentation Engineers</pub><pmid>25985096</pmid><doi>10.1117/1.JBO.20.5.056005</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-3668 |
| ispartof | Journal of biomedical optics, 2015-05, Vol.20 (5), p.056005-056005 |
| issn | 1083-3668 1560-2281 |
| language | eng |
| recordid | cdi_pubmed_primary_25985096 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Contrast Media Coronary Vessels - anatomy & histology Coronary Vessels - diagnostic imaging Dextrans Image Enhancement - methods Iohexol Mannitol Rabbits Reproducibility of Results Research Papers: Imaging Sensitivity and Specificity Tomography, Optical Coherence - methods Ultrasonography, Interventional - methods |
| title | Optimal flushing agents for integrated optical and acoustic imaging systems |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T11%3A42%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Optimal%20flushing%20agents%20for%20integrated%20optical%20and%20acoustic%20imaging%20systems&rft.jtitle=Journal%20of%20biomedical%20optics&rft.au=Li,%20Jiawen&rft.date=2015-05-01&rft.volume=20&rft.issue=5&rft.spage=056005&rft.epage=056005&rft.pages=056005-056005&rft.issn=1083-3668&rft.eissn=1560-2281&rft_id=info:doi/10.1117/1.JBO.20.5.056005&rft_dat=%3Cproquest_pubme%3E1682204110%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1682204110&rft_id=info:pmid/25985096&rfr_iscdi=true |