IFNγ producing CD8+ T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas

Tumors with reduced expression of MHC class I (MHC-I) molecules may be unrecognized by tumor antigen-specific CD8 + T cells and thus constitute a challenge for cancer immunotherapy. Here we monitored development of autochthonous melanomas in TiRP mice that develop tumors expressing a known tumor ant...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Oncoimmunology 2015-02, Vol.4 (2), p.e974959-e974959
Hauptverfasser:	Buferne, Michel, Chasson, Lionel, Grange, Magali, Mas, Amandine, Arnoux, Fanny, Bertuzzi, Mélanie, Naquet, Philippe, Leserman, Lee, Schmitt-Verhulst, Anne-Marie, Auphan-Anezin, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	biofluorescence tumor imaging cancer-germline tumor antigen eTC, effector T cell immunotherapy LN, lymph node MFI, mean fluorescence intensity mouse melanoma model Original Research STAT5, Signal transducer and activator of transcription 5 TA, tumor antigen TILs, tumor infiltrating leukocytes transcription factor tumor escape variants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!