Tumor infiltrating lymphocytes in ovarian cancer

The accumulation of tumor infiltrating lymphocytes (TILs) in ovarian cancer is prognostic for increased survival while increases in immunosuppressive regulatory T-cells (Tregs) are associated with poor outcomes. Approaches that bolster tumor-reactive TILs may limit tumor progression. However, identi...

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Veröffentlicht in:	Cancer biology & therapy 2015-01, Vol.16 (6), p.807-820
Hauptverfasser:	Santoiemma, Phillip P, Powell, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Vaccines - immunology Clinical Trials as Topic Female Humans Immunomodulation immunosuppression immunotherapy Immunotherapy, Adoptive Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Lymphocyte Subsets - pathology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology ovarian cancer Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Prognosis prognostic factors regulatory T-cells Review Treatment Outcome tumor infiltrating lymphocytes Tumor Microenvironment - immunology
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