The Pyridone-Annelated Isoindigo (5‘-Cl) Induces Apoptosis, Dysregulation of Mitochondria and Formation of ROS in Leukemic HL-60 Cells

Background/Aims: In our quest to develop an isoindigo with improved efficacy and bioavailability, we recently synthesized a series of novel substituted pyridone-annelated isoindigo and evaluated their antiproliferative effects. We identified the compound [(E)-1-(5'-Chloro-2'-oxoindolin-3&#...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.35 (5), p.1958-1974
Hauptverfasser:	Saleh, Ayman M., Aljada, Ahmad, El-Abadelah, Mustafa M., Sabri, Salim S., Zahra, Jalal A., Nasr, Amre, Aziz, Mohammad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Amino Acid Chloromethyl Ketones - pharmacology Anticancer compound Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Bax Bcl-2 bcl-2-Associated X Protein - metabolism Cancer cells Caspases - metabolism Cell Line, Tumor Cytochromes Cytochromes c - metabolism Health aspects HL-60 Cells Humans Indoles - chemistry Indoles - pharmacology Leukemia research Leukemia, Promyelocytic, Acute - metabolism Leukemia, Promyelocytic, Acute - pathology Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - metabolism Mitochondria dysfunction Original Paper Phosphorylation - drug effects Phosphorylation of Bcl-2 Physiological aspects Proto-Oncogene Proteins c-bcl-2 - metabolism Pyridone-annelated isoindigo Pyridones - chemistry Pyridones - pharmacology Pyrrolidines - pharmacology Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Thiocarbamates - pharmacology
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