CTGF Positively Regulates BMP12 Induced Tenogenic Differentiation of Tendon Stem Cells and Signaling

Background/Aims: Disordered differentiation of tendon stem cells (TSCs) during repair of injured tendon can result in the pathogenesis of chronic tendinopathy. Understanding tenocyte differentiation may provide new therapeutic insights for the prevention and treatment of chronic tendinopathy. The ai...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.35 (5), p.1831-1845
Hauptverfasser:	Liu, Junpeng, Tao, Xu, Chen, Lei, Han, Weifeng, Zhou, You, Tang, Kanglai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism BMP-12/ Smad1/5/8 pathway Cell differentiation Cell Differentiation - drug effects Cell Lineage Cells, Cultured Cellular signal transduction Collagen Type I - metabolism Connective Tissue Growth Factor - antagonists & inhibitors Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - metabolism CTGF Growth Differentiation Factors - pharmacology Growth factors Health aspects Membrane Proteins - genetics Membrane Proteins - metabolism Original Paper Phosphorylation - drug effects Rats Rats, Sprague-Dawley RNA Interference Signal Transduction - drug effects Smad1 Protein - metabolism Smad5 Protein - metabolism Smad8 Protein - metabolism Stem cell research Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Tenascin - metabolism Tendon stem cells (TSCs) Tendons - cytology Tenogenic differentiation
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