Disposition of 5-Aminosalicylic Acid from 5-Aminosalicylic Acid-Delivering Drugs during Accelerated Intestinal Transit in Healthy Volunteers

In eight healthy volunteers accelerated intestinal transit time was induced with bisacodyl, and urinary and faecal excretion of sulphasalazine, olsalazine, 5-aminosalicylic acid (5-AS A), and acetyl-5-ASA was studied after a single oral dose of 3.3 mmol sulphasalazine, olsalazine, Pentasa±, and Salo...

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Veröffentlicht in:	Scandinavian journal of gastroenterology 1989, Vol.24 (10), p.1179-1185
Hauptverfasser:	Rijk, M. C. M., Van Hogezand, R. A., Schaik, A. Van, Van Tongeren, J. H. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminosalicylic acid Adult Aminosalicylic Acids - administration & dosage Aminosalicylic Acids - metabolism azodisal sodium (olsalazine) Bisacodyl - pharmacology Female Gastrointestinal Transit - drug effects Humans Male Mesalamine metabolism Middle Aged sali-cylazosulphapyridine Sulfasalazine - metabolism
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