Mechanisms of Autophagy
The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and i...
Gespeichert in:
| Veröffentlicht in: | Annual review of biophysics 2015-06, Vol.44 (1), p.101-122 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 122 |
|---|---|
| container_issue | 1 |
| container_start_page | 101 |
| container_title | Annual review of biophysics |
| container_volume | 44 |
| creator | Noda, Nobuo N Inagaki, Fuyuhiko |
| description | The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome. In this review, we describe from a structural-biological point of view the structure, interaction, and molecular roles of Atg proteins, especially those in the Atg1 complex and in the Atg conjugation systems. |
| doi_str_mv | 10.1146/annurev-biophys-060414-034248 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_25747593</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1691017394</sourcerecordid><originalsourceid>FETCH-LOGICAL-a505t-a84dc2394e3b907285d0b2e314ce2eef1f4358d7f5f60d102ea2a120a791ab4b3</originalsourceid><addsrcrecordid>eNqVkDtPwzAUhS0EoqUws6EuSCwGXz-TgaGteElFLCCxWU5yTYPyKHED6r8nVUJ3pnuH75wjfYRcArsGkPrGVVXb4DdN8nq92gbKNJMgKROSy-iAjCEWmgIX0eH-5-8jchLCJ2NKG6mPyYgrI42KxZicP2O6clUeyjCt_XTWbrpa97E9JUfeFQHPhjshb_d3r4tHunx5eFrMltQppjbURTJLuYgliiRmhkcqYwlHATJFjujBS6GizHjlNcuAcXTcAWfOxOASmYgJuep710391WLY2DIPKRaFq7BugwUdAwPTLXTobY-mTR1Cg96um7x0zdYCszs3dnBjBze2d2N7N13-YphqkxKzffpPRgfMe2DX44quKcef8M-VX70oeqI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1691017394</pqid></control><display><type>article</type><title>Mechanisms of Autophagy</title><source>Annual Reviews</source><source>MEDLINE</source><creator>Noda, Nobuo N ; Inagaki, Fuyuhiko</creator><creatorcontrib>Noda, Nobuo N ; Inagaki, Fuyuhiko</creatorcontrib><description>The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome. In this review, we describe from a structural-biological point of view the structure, interaction, and molecular roles of Atg proteins, especially those in the Atg1 complex and in the Atg conjugation systems.</description><identifier>ISSN: 1936-122X</identifier><identifier>EISSN: 1936-1238</identifier><identifier>DOI: 10.1146/annurev-biophys-060414-034248</identifier><identifier>PMID: 25747593</identifier><language>eng</language><publisher>United States: Annual Reviews</publisher><subject>Animals ; Atg1 complex ; Atg12-Atg5-Atg16 complex ; Atg8-PE ; autophagosome formation ; Autophagy ; Humans ; Multiprotein Complexes - chemistry ; Multiprotein Complexes - metabolism ; Phagosomes - metabolism ; pre-autophagsomal structure ; Saccharomyces cerevisiae ; structural biology ; Vesicular Transport Proteins - chemistry ; Vesicular Transport Proteins - metabolism</subject><ispartof>Annual review of biophysics, 2015-06, Vol.44 (1), p.101-122</ispartof><rights>Copyright © 2015 by Annual Reviews. All rights reserved 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a505t-a84dc2394e3b907285d0b2e314ce2eef1f4358d7f5f60d102ea2a120a791ab4b3</citedby><cites>FETCH-LOGICAL-a505t-a84dc2394e3b907285d0b2e314ce2eef1f4358d7f5f60d102ea2a120a791ab4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-biophys-060414-034248?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-biophys-060414-034248$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,776,780,4168,27901,27902,77996,77997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25747593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noda, Nobuo N</creatorcontrib><creatorcontrib>Inagaki, Fuyuhiko</creatorcontrib><title>Mechanisms of Autophagy</title><title>Annual review of biophysics</title><addtitle>Annu Rev Biophys</addtitle><description>The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome. In this review, we describe from a structural-biological point of view the structure, interaction, and molecular roles of Atg proteins, especially those in the Atg1 complex and in the Atg conjugation systems.</description><subject>Animals</subject><subject>Atg1 complex</subject><subject>Atg12-Atg5-Atg16 complex</subject><subject>Atg8-PE</subject><subject>autophagosome formation</subject><subject>Autophagy</subject><subject>Humans</subject><subject>Multiprotein Complexes - chemistry</subject><subject>Multiprotein Complexes - metabolism</subject><subject>Phagosomes - metabolism</subject><subject>pre-autophagsomal structure</subject><subject>Saccharomyces cerevisiae</subject><subject>structural biology</subject><subject>Vesicular Transport Proteins - chemistry</subject><subject>Vesicular Transport Proteins - metabolism</subject><issn>1936-122X</issn><issn>1936-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkDtPwzAUhS0EoqUws6EuSCwGXz-TgaGteElFLCCxWU5yTYPyKHED6r8nVUJ3pnuH75wjfYRcArsGkPrGVVXb4DdN8nq92gbKNJMgKROSy-iAjCEWmgIX0eH-5-8jchLCJ2NKG6mPyYgrI42KxZicP2O6clUeyjCt_XTWbrpa97E9JUfeFQHPhjshb_d3r4tHunx5eFrMltQppjbURTJLuYgliiRmhkcqYwlHATJFjujBS6GizHjlNcuAcXTcAWfOxOASmYgJuep710391WLY2DIPKRaFq7BugwUdAwPTLXTobY-mTR1Cg96um7x0zdYCszs3dnBjBze2d2N7N13-YphqkxKzffpPRgfMe2DX44quKcef8M-VX70oeqI</recordid><startdate>20150622</startdate><enddate>20150622</enddate><creator>Noda, Nobuo N</creator><creator>Inagaki, Fuyuhiko</creator><general>Annual Reviews</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150622</creationdate><title>Mechanisms of Autophagy</title><author>Noda, Nobuo N ; Inagaki, Fuyuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a505t-a84dc2394e3b907285d0b2e314ce2eef1f4358d7f5f60d102ea2a120a791ab4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Atg1 complex</topic><topic>Atg12-Atg5-Atg16 complex</topic><topic>Atg8-PE</topic><topic>autophagosome formation</topic><topic>Autophagy</topic><topic>Humans</topic><topic>Multiprotein Complexes - chemistry</topic><topic>Multiprotein Complexes - metabolism</topic><topic>Phagosomes - metabolism</topic><topic>pre-autophagsomal structure</topic><topic>Saccharomyces cerevisiae</topic><topic>structural biology</topic><topic>Vesicular Transport Proteins - chemistry</topic><topic>Vesicular Transport Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noda, Nobuo N</creatorcontrib><creatorcontrib>Inagaki, Fuyuhiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noda, Nobuo N</au><au>Inagaki, Fuyuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of Autophagy</atitle><jtitle>Annual review of biophysics</jtitle><addtitle>Annu Rev Biophys</addtitle><date>2015-06-22</date><risdate>2015</risdate><volume>44</volume><issue>1</issue><spage>101</spage><epage>122</epage><pages>101-122</pages><issn>1936-122X</issn><eissn>1936-1238</eissn><abstract>The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome. In this review, we describe from a structural-biological point of view the structure, interaction, and molecular roles of Atg proteins, especially those in the Atg1 complex and in the Atg conjugation systems.</abstract><cop>United States</cop><pub>Annual Reviews</pub><pmid>25747593</pmid><doi>10.1146/annurev-biophys-060414-034248</doi><tpages>22</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1936-122X |
| ispartof | Annual review of biophysics, 2015-06, Vol.44 (1), p.101-122 |
| issn | 1936-122X 1936-1238 |
| language | eng |
| recordid | cdi_pubmed_primary_25747593 |
| source | Annual Reviews; MEDLINE |
| subjects | Animals Atg1 complex Atg12-Atg5-Atg16 complex Atg8-PE autophagosome formation Autophagy Humans Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Phagosomes - metabolism pre-autophagsomal structure Saccharomyces cerevisiae structural biology Vesicular Transport Proteins - chemistry Vesicular Transport Proteins - metabolism |
| title | Mechanisms of Autophagy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T15%3A54%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanisms%20of%20Autophagy&rft.jtitle=Annual%20review%20of%20biophysics&rft.au=Noda,%20Nobuo%20N&rft.date=2015-06-22&rft.volume=44&rft.issue=1&rft.spage=101&rft.epage=122&rft.pages=101-122&rft.issn=1936-122X&rft.eissn=1936-1238&rft_id=info:doi/10.1146/annurev-biophys-060414-034248&rft_dat=%3Cproquest_pubme%3E1691017394%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1691017394&rft_id=info:pmid/25747593&rfr_iscdi=true |