Role of tenascins in the ECM of gliomas
Tenascins are a family of extracellular matrix molecules that are mainly expressed in embryonic development and down-regulated in adulthood. A re-expression in the adult occurs under pathological conditions such as inflammation, regeneration or neoplasia. As the most prominent member of the tenascin...
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| Veröffentlicht in: | Cell adhesion & migration 2015-01, Vol.9 (1-2), p.131-140 |
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| creator | Brösicke, Nicole Faissner, Andreas |
| description | Tenascins are a family of extracellular matrix molecules that are mainly expressed in embryonic development and down-regulated in adulthood. A re-expression in the adult occurs under pathological conditions such as inflammation, regeneration or neoplasia. As the most prominent member of the tenascin family, TN-C, is highly expressed in glioma tissue and rising evidence suggests that TN-C plays a crucial role in cell migration or invasion - the most fatal characteristics of glioma - also the other members of this protein family have been investigated with regard to their impact on glioma biology. For all tenascins correlations between the expression levels of the different family members and the degree of malignancy and invasiveness of glial tumors could be detected. Overall, the former and recent results in the research on glioma and tenascins point at distinct roles of each of the molecules in glioma biology and the devastating properties of these tumors. |
| doi_str_mv | 10.1080/19336918.2014.1000071 |
| format | Article |
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Overall, the former and recent results in the research on glioma and tenascins point at distinct roles of each of the molecules in glioma biology and the devastating properties of these tumors.</description><subject>Animals</subject><subject>Brain Neoplasms - metabolism</subject><subject>cell migration</subject><subject>Cell Movement - physiology</subject><subject>central nervous system</subject><subject>extracellular matrix</subject><subject>Extracellular Matrix - metabolism</subject><subject>extracellular matrix receptors</subject><subject>glial stem and progenitors cells</subject><subject>Glioma - metabolism</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Reviews</subject><subject>Tenascin - metabolism</subject><subject>tumor stem cells; angiogenesis</subject><issn>1933-6918</issn><issn>1933-6926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotlZ_gjI73UzNazLJRpRSH1ARRNchSTNtZGZSk6nSf29KH-jGu8nl5NxzLx8A5wgOEeTwGglCmEB8iCGiSUpVogPQX-s5E5gd7nvEe-Akxg8IC44YOwY9XDBRUIj74PLV1zbzVdbZVkXj2pi5NuvmNhuPntf6rHa-UfEUHFWqjvZs-w7A-_34bfSYT14enkZ3k9xQxrtcQ6ER04hzSJXGWBnGSiMgUgIbIriCZTmFylhOuCaMlKjUFSWKknSbLiEZgJtN7mKpGzs1tu2CquUiuEaFlfTKyb8_rZvLmf-SlGJcCpoCrrYBwX8ubexk46Kxda1a65dRJgAFFQXBIlmLjdUEH2Ow1X4NgnINWe4gyzVkuYWc5i5-37if2lFNhtuNwbWVD4369qGeyk6tah-qoFrjoiT_7_gBx_6JaA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Brösicke, Nicole</creator><creator>Faissner, Andreas</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Role of tenascins in the ECM of gliomas</title><author>Brösicke, Nicole ; Faissner, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-b09b16b18804ab22ac667c901a92c398a077d0ace838b363717bf43a43058b703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Brain Neoplasms - metabolism</topic><topic>cell migration</topic><topic>Cell Movement - physiology</topic><topic>central nervous system</topic><topic>extracellular matrix</topic><topic>Extracellular Matrix - metabolism</topic><topic>extracellular matrix receptors</topic><topic>glial stem and progenitors cells</topic><topic>Glioma - metabolism</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Reviews</topic><topic>Tenascin - metabolism</topic><topic>tumor stem cells; angiogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brösicke, Nicole</creatorcontrib><creatorcontrib>Faissner, Andreas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell adhesion & migration</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brösicke, Nicole</au><au>Faissner, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of tenascins in the ECM of gliomas</atitle><jtitle>Cell adhesion & migration</jtitle><addtitle>Cell Adh Migr</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>9</volume><issue>1-2</issue><spage>131</spage><epage>140</epage><pages>131-140</pages><issn>1933-6918</issn><eissn>1933-6926</eissn><abstract>Tenascins are a family of extracellular matrix molecules that are mainly expressed in embryonic development and down-regulated in adulthood. 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| ispartof | Cell adhesion & migration, 2015-01, Vol.9 (1-2), p.131-140 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Brain Neoplasms - metabolism cell migration Cell Movement - physiology central nervous system extracellular matrix Extracellular Matrix - metabolism extracellular matrix receptors glial stem and progenitors cells Glioma - metabolism Homeostasis - physiology Humans Reviews Tenascin - metabolism tumor stem cells angiogenesis |
| title | Role of tenascins in the ECM of gliomas |
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