In vitro and in vivo study of Baicalin-loaded mixed micelles for oral delivery

The aim of this work was to research the potential functions and the mechanism of absorption of the baicalin (BC)-loaded micelle system that contained Pluronic P123 copolymer (P123) and sodium taurocholate (ST) as carrier materials via oral delivery. Based on the numerous advantages of oral administ...

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Veröffentlicht in:	Drug delivery 2016-07, Vol.23 (6), p.1933-1939
Hauptverfasser:	Zhang, Haiqun, Yang, Xiaoye, Zhao, Lili, Jiao, Yan, Liu, Jiyong, Zhai, Guangxi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Baicalin Caco-2 Cells cellular uptake Chemistry, Pharmaceutical Delayed-Action Preparations - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry Flavonoids - administration & dosage Flavonoids - chemistry Humans Micelles mixed micelle oral pharmacokinetics studies Paclitaxel - administration & dosage Paclitaxel - chemistry Poloxalene - chemistry Rats Taurocholic Acid - chemistry X-Ray Diffraction
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