Efficacy and transdermal absorption of permethrin in scabies patients
The clinical efficacy and transdermal absorption of permethrin, a new synthetic insecticide was investigated in ten scabies patients. All patients were successfully treated with one application of a cream, containing 5% permethrin. Apart from mild postscabies dermatitis no side-effects were observed...
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| Veröffentlicht in: | Acta dermato-venereologica 1989, Vol.69 (2), p.170-173 |
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| container_end_page | 173 |
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| container_title | Acta dermato-venereologica |
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| creator | VAN DER RHEE, H. J FARQUHAR, J. A VERMEULEN, N. P. E |
| description | The clinical efficacy and transdermal absorption of permethrin, a new synthetic insecticide was investigated in ten scabies patients. All patients were successfully treated with one application of a cream, containing 5% permethrin. Apart from mild postscabies dermatitis no side-effects were observed. The mean weight of cream used per patient was 25 g (range 21-32; mean content of permethrin 1250 mg). The degree of permethrin absorption was assessed indirectly by determination of conjugated and unconjugated cis- and trans-CVA (a metabolite of permethrin) excretion in urine using two dimensional gas chromatography mass spectrometry. It was found that during the first 48 hours the mean estimated absorption was 6 mg (range 3-11), which is approximately 0.5% of the total dose. |
| format | Article |
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J ; FARQUHAR, J. A ; VERMEULEN, N. P. E</creator><creatorcontrib>VAN DER RHEE, H. J ; FARQUHAR, J. A ; VERMEULEN, N. P. E</creatorcontrib><description>The clinical efficacy and transdermal absorption of permethrin, a new synthetic insecticide was investigated in ten scabies patients. All patients were successfully treated with one application of a cream, containing 5% permethrin. Apart from mild postscabies dermatitis no side-effects were observed. The mean weight of cream used per patient was 25 g (range 21-32; mean content of permethrin 1250 mg). The degree of permethrin absorption was assessed indirectly by determination of conjugated and unconjugated cis- and trans-CVA (a metabolite of permethrin) excretion in urine using two dimensional gas chromatography mass spectrometry. It was found that during the first 48 hours the mean estimated absorption was 6 mg (range 3-11), which is approximately 0.5% of the total dose.</description><identifier>ISSN: 0001-5555</identifier><identifier>EISSN: 1651-2057</identifier><identifier>PMID: 2564238</identifier><identifier>CODEN: ADVEA4</identifier><language>eng</language><publisher>Uppsala: Acta dermato-venereologica</publisher><subject>Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Biological and medical sciences ; Female ; Humans ; Male ; Medical sciences ; Ointments ; Permethrin ; Pharmacology. Drug treatments ; Pyrethrins - administration & dosage ; Pyrethrins - adverse effects ; Pyrethrins - pharmacokinetics ; Scabies - metabolism ; Scabies - pathology ; Skin Absorption</subject><ispartof>Acta dermato-venereologica, 1989, Vol.69 (2), p.170-173</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7189995$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2564238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN DER RHEE, H. J</creatorcontrib><creatorcontrib>FARQUHAR, J. A</creatorcontrib><creatorcontrib>VERMEULEN, N. P. E</creatorcontrib><title>Efficacy and transdermal absorption of permethrin in scabies patients</title><title>Acta dermato-venereologica</title><addtitle>Acta Derm Venereol</addtitle><description>The clinical efficacy and transdermal absorption of permethrin, a new synthetic insecticide was investigated in ten scabies patients. All patients were successfully treated with one application of a cream, containing 5% permethrin. Apart from mild postscabies dermatitis no side-effects were observed. The mean weight of cream used per patient was 25 g (range 21-32; mean content of permethrin 1250 mg). The degree of permethrin absorption was assessed indirectly by determination of conjugated and unconjugated cis- and trans-CVA (a metabolite of permethrin) excretion in urine using two dimensional gas chromatography mass spectrometry. It was found that during the first 48 hours the mean estimated absorption was 6 mg (range 3-11), which is approximately 0.5% of the total dose.</description><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ointments</subject><subject>Permethrin</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrethrins - administration & dosage</subject><subject>Pyrethrins - adverse effects</subject><subject>Pyrethrins - pharmacokinetics</subject><subject>Scabies - metabolism</subject><subject>Scabies - pathology</subject><subject>Skin Absorption</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9T0tLAzEQDqLUWv0JQg5eFzJJ8zpKWbVQ8KLnMptNMLKPsImH_nsDLg4Dw_dg-L4rsgUloeFM6muyZYxBI-vckrucvyvkEsyGbLhUey7MlrRtCNGhu1CceloWnHLvlxEHil2el1TiPNE50FRJX76WONG62WEXfaYJS_RTyffkJuCQ_cN6d-Tzpf04vDWn99fj4fnUJC5kaazkjBnDQGjtoAfgFoy2Xu4114Zza0QfXAcYuGLegFSWBaWdQuRSMit25PHvb_rpRt-f0xJHXC7ntU7Vn1Yda8Qh1Dou5n-bBmOtleIXpppSog</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>VAN DER RHEE, H. J</creator><creator>FARQUHAR, J. A</creator><creator>VERMEULEN, N. P. E</creator><general>Acta dermato-venereologica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>1989</creationdate><title>Efficacy and transdermal absorption of permethrin in scabies patients</title><author>VAN DER RHEE, H. J ; FARQUHAR, J. A ; VERMEULEN, N. P. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-952008801377c1d11291879e54727822983dfcb1af260e815690f67c6aa255093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ointments</topic><topic>Permethrin</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrethrins - administration & dosage</topic><topic>Pyrethrins - adverse effects</topic><topic>Pyrethrins - pharmacokinetics</topic><topic>Scabies - metabolism</topic><topic>Scabies - pathology</topic><topic>Skin Absorption</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DER RHEE, H. J</creatorcontrib><creatorcontrib>FARQUHAR, J. A</creatorcontrib><creatorcontrib>VERMEULEN, N. P. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN DER RHEE, H. J</au><au>FARQUHAR, J. A</au><au>VERMEULEN, N. P. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and transdermal absorption of permethrin in scabies patients</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>1989</date><risdate>1989</risdate><volume>69</volume><issue>2</issue><spage>170</spage><epage>173</epage><pages>170-173</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><coden>ADVEA4</coden><abstract>The clinical efficacy and transdermal absorption of permethrin, a new synthetic insecticide was investigated in ten scabies patients. All patients were successfully treated with one application of a cream, containing 5% permethrin. Apart from mild postscabies dermatitis no side-effects were observed. The mean weight of cream used per patient was 25 g (range 21-32; mean content of permethrin 1250 mg). The degree of permethrin absorption was assessed indirectly by determination of conjugated and unconjugated cis- and trans-CVA (a metabolite of permethrin) excretion in urine using two dimensional gas chromatography mass spectrometry. It was found that during the first 48 hours the mean estimated absorption was 6 mg (range 3-11), which is approximately 0.5% of the total dose.</abstract><cop>Uppsala</cop><pub>Acta dermato-venereologica</pub><pmid>2564238</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Acta dermato-venereologica, 1989, Vol.69 (2), p.170-173 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Female Humans Male Medical sciences Ointments Permethrin Pharmacology. Drug treatments Pyrethrins - administration & dosage Pyrethrins - adverse effects Pyrethrins - pharmacokinetics Scabies - metabolism Scabies - pathology Skin Absorption |
| title | Efficacy and transdermal absorption of permethrin in scabies patients |
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