Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats

Abstract Gentamicin is commonly used against gram-negative microorganisms. Its therapeutic use is mainly limited by nephrotoxicity. This study was aimed at evaluating the effect of rutin on oxidative stress, inflammation, apoptosis, and autophagy in gentamicin-induced nephrotoxicity in rats. The rat...

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Veröffentlicht in:	Renal failure 2015-04, Vol.37 (3), p.518-525
Hauptverfasser:	Kandemir, Fatih Mehmet, Ozkaraca, Mustafa, Yildirim, Betul Apaydin, Hanedan, Basak, Kirbas, Akin, Kilic, Kubra, Aktas, Esra, Benzer, Fulya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology apoptosis Apoptosis - drug effects autophagy Autophagy - drug effects Disease Models, Animal Gentamicin Gentamicins - adverse effects Glutathione Peroxidase - metabolism Inflammation - drug therapy Inflammation - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - drug therapy Kidney Diseases - metabolism Kidney Diseases - physiopathology Kidney Function Tests Malondialdehyde - metabolism nephrotoxicity Nitric Oxide Synthase Type II - metabolism oxidative stress Oxidative Stress - drug effects Protective Agents - pharmacology Rats Rats, Sprague-Dawley rutin Rutin - pharmacology Superoxide Dismutase - metabolism
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