Phorbol esters inhibit chondrogenesis in limb mesenchyme by mechanisms independent of PGE2 or cyclic AMP1

Effects of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on chondrogenesis and concentrations of prostaglandin E2 (PGE2) and cyclic AMP (cAMP) were investigated in micromass cultures of chick limb mesenchyme derived from the distal tip of stage 25 limb buds. TPA completely inhibited c...

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Veröffentlicht in:	Experimental cell research 1989-12, Vol.185 (2), p.541
Hauptverfasser:	Biddulph, D M, Dozier, M M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage - cytology Cartilage - drug effects Cartilage - embryology Cells, Cultured Chick Embryo Cyclic AMP - metabolism Dinoprostone - metabolism Extremities Kinetics Tetradecanoylphorbol Acetate - pharmacology
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