Microtubule stabilization with paclitaxel does not protect against infarction in isolated rat hearts

What is the central question of this study? The microtubule network is disrupted during myocardial ischaemia-reperfusion injury. It was suggested that prevention of microtubule disruption with paclitaxel might reduce cardiac infarct size; however, the effects on infarction have not been studied. Wha...

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Veröffentlicht in:	Experimental physiology 2015-01, Vol.100 (1), p.23
Hauptverfasser:	Rodríguez-Sinovas, Antonio, Abad, Elena, Sánchez, Jose A, Fernández-Sanz, Celia, Inserte, Javier, Ruiz-Meana, Marisol, Alburquerque-Béjar, Juan José, García-Dorado, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Signaling - drug effects Colchicine - pharmacology Cytoprotection Dose-Response Relationship, Drug Heart Rate - drug effects In Vitro Techniques Male Mechanotransduction, Cellular - drug effects Microtubules - drug effects Microtubules - metabolism Microtubules - pathology Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Paclitaxel - pharmacology Rats, Sprague-Dawley Stress, Mechanical Tubulin Modulators - pharmacology Ventricular Function, Left - drug effects Ventricular Pressure - drug effects
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