Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits
Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondri...
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| Veröffentlicht in: | Frontiers in bioscience 2015-01, Vol.20 (5), p.892-901, Article 4343 |
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| creator | Iomdina, Elena N Khoroshilova-Maslova, Inna P Robustova, Olga V Averina, Olga A Kovaleva, Nadezhda A Aliev, Gjumrakch Reddy, V Prakash Zamyatnin, Jr, Andrey A Skulachev, Maxim V Senin, Ivan I Skulachev, Vladimir P |
| description | Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5-5 microM solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma. |
| doi_str_mv | 10.2741/4343 |
| format | Article |
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This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5-5 microM solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma.</description><identifier>ISSN: 1093-9946</identifier><identifier>EISSN: 2768-6698</identifier><identifier>EISSN: 1093-4715</identifier><identifier>DOI: 10.2741/4343</identifier><identifier>PMID: 25553485</identifier><language>eng</language><publisher>Singapore</publisher><subject>Animals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Disease Models, Animal ; Glaucoma - drug therapy ; Glaucoma - physiopathology ; Intraocular Pressure - drug effects ; Male ; Mitochondria - drug effects ; Plastoquinone - analogs & derivatives ; Plastoquinone - pharmacology ; Plastoquinone - therapeutic use ; Rabbits</subject><ispartof>Frontiers in bioscience, 2015-01, Vol.20 (5), p.892-901, Article 4343</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-d7b5fede887a54efe352d0a08ada88e2af81583c24f39f4f20865b8e97065a323</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25553485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iomdina, Elena N</creatorcontrib><creatorcontrib>Khoroshilova-Maslova, Inna P</creatorcontrib><creatorcontrib>Robustova, Olga V</creatorcontrib><creatorcontrib>Averina, Olga A</creatorcontrib><creatorcontrib>Kovaleva, Nadezhda A</creatorcontrib><creatorcontrib>Aliev, Gjumrakch</creatorcontrib><creatorcontrib>Reddy, V Prakash</creatorcontrib><creatorcontrib>Zamyatnin, Jr, Andrey A</creatorcontrib><creatorcontrib>Skulachev, Maxim V</creatorcontrib><creatorcontrib>Senin, Ivan I</creatorcontrib><creatorcontrib>Skulachev, Vladimir P</creatorcontrib><title>Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits</title><title>Frontiers in bioscience</title><addtitle>Front Biosci (Landmark Ed)</addtitle><description>Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5-5 microM solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Glaucoma - drug therapy</subject><subject>Glaucoma - physiopathology</subject><subject>Intraocular Pressure - drug effects</subject><subject>Male</subject><subject>Mitochondria - drug effects</subject><subject>Plastoquinone - analogs & derivatives</subject><subject>Plastoquinone - pharmacology</subject><subject>Plastoquinone - therapeutic use</subject><subject>Rabbits</subject><issn>1093-9946</issn><issn>2768-6698</issn><issn>1093-4715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtKAzEUQIMotrT9BcnC7WieM8lSii-oFFHXw53JTY22k5Kkon-vperqbA5ncQiZcnYhGsUvlVTyiIxFU5uqrq05JmPOrKysVfWIzHJ-Y4wJy7nV5pSMhNZaKqPHZPkQSuxf4-BSgKpAWmFBR2EoIX4G90P69P7IacIPTBkzXa1h18cNlLjLdI05xCHTMNAEXRdKnpITD-uMs19OyMvN9fP8rlosb-_nV4uql0yXyjWd9ujQmAa0Qo9SC8eAGXBgDArwhmsje6G8tF55wUytO4O2YbUGKeSEnB-6fYo5J_TtNoUNpK-Ws3a_pN0v-dHODtp2123Q_Ut_A-Q3ewZbrw</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Iomdina, Elena N</creator><creator>Khoroshilova-Maslova, Inna P</creator><creator>Robustova, Olga V</creator><creator>Averina, Olga A</creator><creator>Kovaleva, Nadezhda A</creator><creator>Aliev, Gjumrakch</creator><creator>Reddy, V Prakash</creator><creator>Zamyatnin, Jr, Andrey A</creator><creator>Skulachev, Maxim V</creator><creator>Senin, Ivan I</creator><creator>Skulachev, Vladimir P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20150101</creationdate><title>Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits</title><author>Iomdina, Elena N ; Khoroshilova-Maslova, Inna P ; Robustova, Olga V ; Averina, Olga A ; Kovaleva, Nadezhda A ; Aliev, Gjumrakch ; Reddy, V Prakash ; Zamyatnin, Jr, Andrey A ; Skulachev, Maxim V ; Senin, Ivan I ; Skulachev, Vladimir P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-d7b5fede887a54efe352d0a08ada88e2af81583c24f39f4f20865b8e97065a323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Glaucoma - drug therapy</topic><topic>Glaucoma - physiopathology</topic><topic>Intraocular Pressure - drug effects</topic><topic>Male</topic><topic>Mitochondria - drug effects</topic><topic>Plastoquinone - analogs & derivatives</topic><topic>Plastoquinone - pharmacology</topic><topic>Plastoquinone - therapeutic use</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iomdina, Elena N</creatorcontrib><creatorcontrib>Khoroshilova-Maslova, Inna P</creatorcontrib><creatorcontrib>Robustova, Olga V</creatorcontrib><creatorcontrib>Averina, Olga A</creatorcontrib><creatorcontrib>Kovaleva, Nadezhda A</creatorcontrib><creatorcontrib>Aliev, Gjumrakch</creatorcontrib><creatorcontrib>Reddy, V Prakash</creatorcontrib><creatorcontrib>Zamyatnin, Jr, Andrey A</creatorcontrib><creatorcontrib>Skulachev, Maxim V</creatorcontrib><creatorcontrib>Senin, Ivan I</creatorcontrib><creatorcontrib>Skulachev, Vladimir P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Frontiers in bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iomdina, Elena N</au><au>Khoroshilova-Maslova, Inna P</au><au>Robustova, Olga V</au><au>Averina, Olga A</au><au>Kovaleva, Nadezhda A</au><au>Aliev, Gjumrakch</au><au>Reddy, V Prakash</au><au>Zamyatnin, Jr, Andrey A</au><au>Skulachev, Maxim V</au><au>Senin, Ivan I</au><au>Skulachev, Vladimir P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits</atitle><jtitle>Frontiers in bioscience</jtitle><addtitle>Front Biosci (Landmark Ed)</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>20</volume><issue>5</issue><spage>892</spage><epage>901</epage><pages>892-901</pages><artnum>4343</artnum><issn>1093-9946</issn><eissn>2768-6698</eissn><eissn>1093-4715</eissn><abstract>Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. 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| subjects | Animals Antioxidants - pharmacology Antioxidants - therapeutic use Disease Models, Animal Glaucoma - drug therapy Glaucoma - physiopathology Intraocular Pressure - drug effects Male Mitochondria - drug effects Plastoquinone - analogs & derivatives Plastoquinone - pharmacology Plastoquinone - therapeutic use Rabbits |
| title | Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits |
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