The transcription factor p53: Not a repressor, solely an activator

The predominant function of the tumor suppressor p53 is transcriptional regulation. It is generally accepted that p53-dependent transcriptional activation occurs by binding to a specific recognition site in promoters of target genes. Additionally, several models for p53-dependent transcriptional rep...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2014-10, Vol.13 (19), p.3037-3058
Hauptverfasser:	Fischer, Martin, Steiner, Lydia, Engeland, Kurt
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites CDKN1A Chromatin Immunoprecipitation Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism DREAM complex E2F Transcription Factors - chemistry E2F Transcription Factors - genetics E2F Transcription Factors - metabolism E2F/RB complex genome-wide meta-analysis HCT116 Cells Humans Meta-Analysis as Topic Promoter Regions, Genetic Protein Binding Real-Time Polymerase Chain Reaction Repressor Proteins - genetics Repressor Proteins - metabolism Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism RNA, Messenger - metabolism RNA, Untranslated - metabolism Signal Transduction Transcriptional Activation Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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