RAD6 Promotes Homologous Recombination Repair by Activating the Autophagy-Mediated Degradation of Heterochromatin Protein HP1

Efficient DNA double-strand break (DSB) repair is critical for the maintenance of genome stability. Unrepaired or misrepaired DSBs cause chromosomal rearrangements that can result in severe consequences, such as tumorigenesis. RAD6 is an E2 ubiquitin-conjugating enzyme that plays a pivotal role in r...

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Veröffentlicht in:	Molecular and cellular biology 2015-01, Vol.35 (2), p.406-416
Hauptverfasser:	Chen, Su, Wang, Chen, Sun, Luxi, Wang, Da-Liang, Chen, Lu, Huang, Zhuan, Yang, Qi, Gao, Jie, Yang, Xi-Bin, Chang, Jian-Feng, Chen, Ping, Lan, Li, Mao, Zhiyong, Sun, Fang-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - genetics Cell Line Chromosomal Proteins, Non-Histone - metabolism Heterochromatin - metabolism Humans Recombinational DNA Repair - genetics Ubiquitin-Conjugating Enzymes - metabolism
Online-Zugang:	Volltext
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