CXCR4 WHIM-like frameshift and nonsense mutations promote ibrutinib resistance but do not supplant MYD88(L265P) -directed survival signalling in Waldenström macroglobulinaemia cells

CXCR4(WHIM) frameshift and nonsense mutations follow MYD88(L265P) as the most common somatic variants in Waldenström Macroglobulinaemia (WM), and impact clinical presentation and ibrutinib response. While the nonsense (CXCR4(S338X) ) mutation has been investigated, little is known about CXCR4 frames...

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Veröffentlicht in:	British journal of haematology 2015-03, Vol.168 (5), p.701
Hauptverfasser:	Cao, Yang, Hunter, Zachary R, Liu, Xia, Xu, Lian, Yang, Guang, Chen, Jie, Tsakmaklis, Nickolas, Kanan, Sandra, Castillo, Jorge J, Treon, Steven P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Apoptosis - drug effects Apoptosis - genetics Cell Survival - drug effects Cell Survival - genetics Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Codon, Nonsense Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Frameshift Mutation Humans Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Pyrazoles - pharmacology Pyrimidines - pharmacology Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Signal Transduction - drug effects Signal Transduction - genetics Tumor Cells, Cultured Waldenstrom Macroglobulinemia - genetics Waldenstrom Macroglobulinemia - metabolism Waldenstrom Macroglobulinemia - pathology
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