The Weaned Pig as a Model for Doxorubicin-Induced Mucositis

Background: Chemotherapy-induced mucositis (CIM) complicates cancer therapy and limits maximum tolerated doses and efficacy. Rodent models do not reproducibly mimic clinical CIM, so alternative models are needed. Methods: CIM severity was assessed after weaned pigs were treated with doxorubicin (5 a...

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Veröffentlicht in:	Chemotherapy (Basel) 2014-01, Vol.60 (1), p.24-36
Hauptverfasser:	Martin, Jamee, Howard, Scott C., Pillai, Asha, Vogel, Peter, Naren, Anjaparavanda P., Davis, Steven, Ringwald-Smith, Karen, Buddington, Karyl, Buddington, Randal K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity Biological and medical sciences Chemotherapy Disease Models, Animal Doxorubicin - toxicity Eating - drug effects Experimental Chemotherapy Glucose - metabolism Hogs Interleukin-10 - blood Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Medical sciences Mucositis - chemically induced Mucositis - pathology Mucous membrane Pharmacology. Drug treatments Side effects Swine Tumor Necrosis Factor-alpha - blood Weight Gain - drug effects
Online-Zugang:	Volltext
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