Inhibition of aflatoxin B1 binding to hepatic DNA by dehydroepiandrosterone in vivo

Dehydroepiandrosterone (DHEA) a naturally occurring steroid, has been reported to inhibit the binding of N-dimethylnitrosamine and 7,12-dimethylbenz[a]anthracene to DNA in vivo and to increase glutathione transferase activity. In this study, we have investigated if DHEA could protect hepatic DNA fro...

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Veröffentlicht in:	Carcinogenesis (New York) 1989-12, Vol.10 (12), p.2197-2200
Hauptverfasser:	Prassanna, Hullahalli R., Lu, Ming H., Beland, Frederick A., Hart, Ronald W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin B1 Aflatoxins - metabolism Aflatoxins - pharmacokinetics Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Dehydroepiandrosterone - metabolism DNA - isolation & purification DNA - metabolism Liver - drug effects Liver - metabolism Male Medical sciences Protein Binding Rats Rats, Inbred F344 Reference Values Subcellular Fractions - metabolism Tumors
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