Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells

IL-1 family member IL-37 limits innate inflammation in models of colitis and LPS-induced shock, but a role in adaptive immunity remains unknown. Here, we studied mice expressing human IL-37b isoform (IL-37tg) subjected to skin contact hypersensitivity (CHS) to dinitrofluorobenzene. CHS challenge to...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-10, Vol.111 (42), p.15178-15183
Hauptverfasser:	Luo, Yuchun, Cai, Xiangna, Liu, Sucai, Wang, Sen, Nold-Petry, Claudia A., Nold, Marcel F., Bufler, Philip, Norris, David, Dinarello, Charles A., Fujita, Mayumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Antigens Biological Sciences CD8-Positive T-Lymphocytes - cytology Cell Movement Cells Chemotaxis contact dermatitis Cytokines Cytokines - metabolism Dendritic cells Dendritic Cells - cytology Dermatitis, Contact - immunology Dinitrofluorobenzene - chemistry Flow Cytometry Gene expression Haptens - chemistry Humans hypersensitivity immune response Immunity, Innate Inflammation innate immunity interleukin-1 Interleukin-1 - metabolism lymph nodes Mice Mice, Inbred C57BL Mice, Transgenic migratory behavior Phagocytosis Rodents Sensitization Skin Skin - metabolism T lymphocytes T-Lymphocytes, Regulatory - cytology transgenic animals Vehicles
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