Label-free electrochemical detection of human methyltransferase from tumors

The role of abnormal DNA methyltransferase activity in the development and progression of cancer is an essential and rapidly growing area of research, both for improved diagnosis and treatment. However, current technologies for the assessment of methyltransferase activity, particularly from crude tu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-10, Vol.111 (42), p.14985-14989
Hauptverfasser:	Furst, Ariel L., Muren, Natalie B., Hill, Michael G., Barton, Jacqueline K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Catalysis Cell Line, Tumor Colorectal cancer Colorectal neoplasms Colorectal Neoplasms - metabolism Cultured cells Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation Electrocatalysis Electrochemistry - methods Electrodes Enzyme kinetics Enzymes HCT116 Cells Humans Methylation Neoplasms - metabolism Phosphates Physical Sciences Tissue culture techniques Tissue samples Tumors
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