Preparation and optimization of N-trimethyl-O-carboxymethyl chitosan nanoparticles for delivery of low-molecular-weight heparin

The aim of this study was preparation, optimization and in vitro characterization of nanoparticles composed of 6-[O-carboxymethyl]-[N,N,N-trimethyl] (TMCMC) for oral delivery of low-molecular-weight heparin. The chitosan derivative was synthesized. Nanoparticles were prepared using the polyelectroly...

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Veröffentlicht in:	Pharmaceutical development and technology 2016-01, Vol.21 (1), p.14-25
Hauptverfasser:	Mahjub, Reza, Heidari Shayesteh, Tavakol, Radmehr, Moojan, Vafaei, Seyed Yaser, Amini, Mohsen, Dinarvand, Rasoul, Dorkoosh, Farid Abedin
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cells Cell Survival - drug effects Chitosan - administration & dosage Chitosan - analogs & derivatives Chitosan - chemical synthesis Drug Delivery Systems - methods Heparin, Low-Molecular-Weight - administration & dosage Heparin, Low-Molecular-Weight - chemical synthesis Humans Low-molecular-weight heparin nanoparticle Nanoparticles - administration & dosage Nanoparticles - chemistry oral delivery Particle Size poly electrolyte complexation trimethyl carboxymethyl chitosan
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