Therapeutic Modulation of Urinary Bladder Function: Multiple Targets at Multiple Levels

Storage dysfunction of the urinary bladder, specifically overactive bladder syndrome, is a condition that occurs frequently in the general population. Historically, pathophysiological and treatment concepts related to overactive bladder have focused on smooth muscle cells. Although these are the cen...

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Veröffentlicht in:	Annual review of pharmacology and toxicology 2015-01, Vol.55 (1), p.269-287
1. Verfasser:	Michel, Martin C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Antagonists - therapeutic use Adrenergic beta-Agonists - therapeutic use adrenoceptor antagonist afferent nerve Animals Central Nervous System - drug effects Central Nervous System - metabolism Central Nervous System - physiopathology Humans Muscarinic Antagonists - therapeutic use muscarinic receptor antagonist Muscle, Smooth - drug effects Muscle, Smooth - innervation Muscle, Smooth - metabolism Muscle, Smooth - physiopathology Neurons, Afferent - drug effects Neurons, Afferent - metabolism Neurons, Efferent - drug effects Neurons, Efferent - metabolism Signal Transduction - drug effects Treatment Outcome Urinary Bladder - drug effects Urinary Bladder - innervation Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder - physiopathology Urinary Bladder Diseases - diagnosis Urinary Bladder Diseases - drug therapy Urinary Bladder Diseases - metabolism Urinary Bladder Diseases - physiopathology Urodynamics - drug effects Urological Agents - adverse effects Urological Agents - therapeutic use urothelium Urothelium - drug effects Urothelium - innervation Urothelium - metabolism Urothelium - physiopathology β-adrenoceptor agonist
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