EVALUATION OF THE EFFICACY OF CEFTRIAXONE IN ACUTE SUPPURATIVE OTITIS MEDIA AND ACUTE EXACERBATION OF CHRONIC SUPPURATIVE OTITIS MEDIA: A COMPARATIVE STUDY WITH CEFOTIAM AS THE CONTROL
In order to objectively evaluate the efficacy and the safety of ceftriaxone (CTRX) using once daily administration of 1g to cases of acute suppurative otitis media and acute exacerbation of chronic suppurative otitis media, a group comparison study by the envelope method was conducted using cefotiam...
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| Veröffentlicht in: | Japanese journal of antibiotics 1989/01/25, Vol.42(1), pp.212-247 |
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| creator | BABA, SHUNKICHI MORI, YOSHITO SUZUKI, KENJI UNNO, TOKUJI KAWABORI, SHINICHI YANAI, TORU NONAKA, SATOSHI TAKASAKA, TOMONORI AWATAGUCHI, TOSHIICHI FURUUCHI, ICHIRO TANIGAITO, YOSHIYUKI GOTOH, HIRONORI KIYONO, JIN KAWABATA, ISUZU KAWAMURA, SHOUZO UEHARA, NORIO ITABASHI, TAKATSUGU FUJIMAKI, YUTAKA NOMURA, YASUYA MIZUNO, MASAHIRO INOUE, NORIFUMI SHOUJI, MINORU ISHII, TETSUO TAKAYAMA, MIKIKO MIYAKE, HIROSATO SHINKAWA, ATSUSHI SAKAI, MAKOTO KOMATSU, NOBUYUKI MATSUKAWA, JUNICHI KAN, SHIMEI KIMURA, HIDENARI MARUO, TAKESHI ITOH, HARUO KINOSHITA, HARUJI KOBAYASHI, TAKEHIRO KAWAI, TAKASHI TAKANO, TSUYOSHI MATSUNAGA, TORU OGINO, HITOSHI ASAI, HIDEYO SHIRAISHI, TAKAYUKI SENBA, OSAMU NOTAKE, KEIKO TAMAKI, HIROMITSU KIMU, SONJIN TSUDA, MAMORU FURUKAWA, YUTAKA TAKEMOTO, ICHIE ISHIDA, MINORU TAYA, NAOZO NOIRI, TERUHISA HORI, TETSUJI MATSUNAGA, TAKASHI TANAKA, OSAMU OKASAKA, TOSHIAKI YANAGAWA, AKIHISA HYOU, YUKIKAZU KITAOKU, NORIYUKI KITAMURA, HIROYUKI NISHIKAWA, ATSUKO FUJITA, NOBUYA KASHIWAGI, NORIKO YANE, KATSUNARI HARADA, YASUO YAJIN, KOUJI TAGASHIRA, NOBUHARU SUZUKI, MAMORU TAKEBAYASHI, SYUBUN YASHIKI, TAKEO CHIKUIE, DAISUKE NODA, MASUHIRO OKAZAKI, HIDETO YOSHIOKA, TATSUO NINOMIYA, YUKO KIKUYA, YOSHINORI KUROKAWA, MICHINORI MURAKAMI, YUZURU MOGI, GORO KURONO, YUICHI YUMISAKI, AKITERU MORIMITSU, TAMOTSU SAKU, KAZUAKI HAYASHI, AKITOSHI MATSUMOTO, ICHIRO KASANO, FUJIHIKO OYAMA, MASARU FURUTA, SHIGERU NOBORI, TAKUO FUKAMI, KOZO FUKUDA, KATSUNORI HIROTA, TSUNEHARU MURANO, KENZO HASHIMOTO, MAKOTO HARAGUCHI, KANEAKI OHORI, YASUICHI IIDA, FUMIKO MATSUNAGA, SHINYA HANADA, TAKEHIRO DEGUCHI, KOUICHI NAKASHIMA, MITSUYOSHI |
| description | In order to objectively evaluate the efficacy and the safety of ceftriaxone (CTRX) using once daily administration of 1g to cases of acute suppurative otitis media and acute exacerbation of chronic suppurative otitis media, a group comparison study by the envelope method was conducted using cefotiam (CTM) as the control drug (2g twice daily). The results obtained are summarized as follows. 1. Clinical efficacies evaluated by the committee were 71% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 63% and 60%, respectively, for chronic suppurative otitis media. When all cases were considered both groups evidenced a clinical efficacy of 64%, and no significant difference was observed between the 2 groups. 2. Clinical efficacies evaluated by the physician in charge were 65% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 72% and 60%, respectively, for chronic suppurative otitis media. When all cases were considered efficacies were, respectively, 70% and 64%, showing no significant difference between the 2 groups. 3. Bacteriological efficacies were 88% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 74% and 62%, respectively, for chronic suppurative otitis media. With all cases bacterial eradication rates were, respectively, 76% and 67%. Bacterial eradication rates were always higher for the CTRX group than for the CTM group, but the difference was not significant between the 2 groups. 4. Against infections caused by Staphylococcus aureus alone, CTRX showed equal clinical and bacteriological efficacies to CTM. 5. As side effects, dermatitis, vomiting, and malaise were observed in 5 cases (4%) of the CTRX group and 3 cases (3%) of the CTM group. As clinical testing abnormalities, elevations of GOT, GPT, and Al-P, and thrombocytopenia were noted only in 3 cases (5%) of the CTRX group. Furthermore, all of these abnormalities were temporary and of moderate degree or mild, thus the safety of either drug was considered high. 6. Clinical utilities were 71% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 72% and 62%, respectively, for chronic suppurative otitis media. When all cases were included, they were 72% and 66%, respectively, and there was no significant difference between the 2 groups. It is concluded from the above results that CTRX is a highly useful drug with once daily administration of 1g in the treatment of suppurativ |
| doi_str_mv | 10.11553/antibiotics1968b.42.212 |
| format | Article |
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MORI, YOSHITO ; SUZUKI, KENJI ; UNNO, TOKUJI ; KAWABORI, SHINICHI ; YANAI, TORU ; NONAKA, SATOSHI ; TAKASAKA, TOMONORI ; AWATAGUCHI, TOSHIICHI ; FURUUCHI, ICHIRO ; TANIGAITO, YOSHIYUKI ; GOTOH, HIRONORI ; KIYONO, JIN ; KAWABATA, ISUZU ; KAWAMURA, SHOUZO ; UEHARA, NORIO ; ITABASHI, TAKATSUGU ; FUJIMAKI, YUTAKA ; NOMURA, YASUYA ; MIZUNO, MASAHIRO ; INOUE, NORIFUMI ; SHOUJI, MINORU ; ISHII, TETSUO ; TAKAYAMA, MIKIKO ; MIYAKE, HIROSATO ; SHINKAWA, ATSUSHI ; SAKAI, MAKOTO ; KOMATSU, NOBUYUKI ; MATSUKAWA, JUNICHI ; KAN, SHIMEI ; KIMURA, HIDENARI ; MARUO, TAKESHI ; ITOH, HARUO ; KINOSHITA, HARUJI ; KOBAYASHI, TAKEHIRO ; KAWAI, TAKASHI ; TAKANO, TSUYOSHI ; MATSUNAGA, TORU ; OGINO, HITOSHI ; ASAI, HIDEYO ; SHIRAISHI, TAKAYUKI ; SENBA, OSAMU ; NOTAKE, KEIKO ; TAMAKI, HIROMITSU ; KIMU, SONJIN ; TSUDA, MAMORU ; FURUKAWA, YUTAKA ; TAKEMOTO, ICHIE ; ISHIDA, MINORU ; TAYA, NAOZO ; NOIRI, TERUHISA ; HORI, TETSUJI ; MATSUNAGA, TAKASHI ; TANAKA, OSAMU ; OKASAKA, TOSHIAKI ; YANAGAWA, AKIHISA ; HYOU, YUKIKAZU ; KITAOKU, NORIYUKI ; KITAMURA, HIROYUKI ; NISHIKAWA, ATSUKO ; FUJITA, NOBUYA ; KASHIWAGI, NORIKO ; YANE, KATSUNARI ; HARADA, YASUO ; YAJIN, KOUJI ; TAGASHIRA, NOBUHARU ; SUZUKI, MAMORU ; TAKEBAYASHI, SYUBUN ; YASHIKI, TAKEO ; CHIKUIE, DAISUKE ; NODA, MASUHIRO ; OKAZAKI, HIDETO ; YOSHIOKA, TATSUO ; NINOMIYA, YUKO ; KIKUYA, YOSHINORI ; KUROKAWA, MICHINORI ; MURAKAMI, YUZURU ; MOGI, GORO ; KURONO, YUICHI ; YUMISAKI, AKITERU ; MORIMITSU, TAMOTSU ; SAKU, KAZUAKI ; HAYASHI, AKITOSHI ; MATSUMOTO, ICHIRO ; KASANO, FUJIHIKO ; OYAMA, MASARU ; FURUTA, SHIGERU ; NOBORI, TAKUO ; FUKAMI, KOZO ; FUKUDA, KATSUNORI ; HIROTA, TSUNEHARU ; MURANO, KENZO ; HASHIMOTO, MAKOTO ; HARAGUCHI, KANEAKI ; OHORI, YASUICHI ; IIDA, FUMIKO ; MATSUNAGA, SHINYA ; HANADA, TAKEHIRO ; DEGUCHI, KOUICHI ; NAKASHIMA, MITSUYOSHI</creator><creatorcontrib>BABA, SHUNKICHI ; MORI, YOSHITO ; SUZUKI, KENJI ; UNNO, TOKUJI ; KAWABORI, SHINICHI ; YANAI, TORU ; NONAKA, SATOSHI ; TAKASAKA, TOMONORI ; AWATAGUCHI, TOSHIICHI ; FURUUCHI, ICHIRO ; TANIGAITO, YOSHIYUKI ; GOTOH, HIRONORI ; KIYONO, JIN ; KAWABATA, ISUZU ; KAWAMURA, SHOUZO ; UEHARA, NORIO ; ITABASHI, TAKATSUGU ; FUJIMAKI, YUTAKA ; NOMURA, YASUYA ; MIZUNO, MASAHIRO ; INOUE, NORIFUMI ; SHOUJI, MINORU ; ISHII, TETSUO ; TAKAYAMA, MIKIKO ; MIYAKE, HIROSATO ; SHINKAWA, ATSUSHI ; SAKAI, MAKOTO ; KOMATSU, NOBUYUKI ; MATSUKAWA, JUNICHI ; KAN, SHIMEI ; KIMURA, HIDENARI ; MARUO, TAKESHI ; ITOH, HARUO ; KINOSHITA, HARUJI ; KOBAYASHI, TAKEHIRO ; KAWAI, TAKASHI ; TAKANO, TSUYOSHI ; MATSUNAGA, TORU ; OGINO, HITOSHI ; ASAI, HIDEYO ; SHIRAISHI, TAKAYUKI ; SENBA, OSAMU ; NOTAKE, KEIKO ; TAMAKI, HIROMITSU ; KIMU, SONJIN ; TSUDA, MAMORU ; FURUKAWA, YUTAKA ; TAKEMOTO, ICHIE ; ISHIDA, MINORU ; TAYA, NAOZO ; NOIRI, TERUHISA ; HORI, TETSUJI ; MATSUNAGA, TAKASHI ; TANAKA, OSAMU ; OKASAKA, TOSHIAKI ; YANAGAWA, AKIHISA ; HYOU, YUKIKAZU ; KITAOKU, NORIYUKI ; KITAMURA, HIROYUKI ; NISHIKAWA, ATSUKO ; FUJITA, NOBUYA ; KASHIWAGI, NORIKO ; YANE, KATSUNARI ; HARADA, YASUO ; YAJIN, KOUJI ; TAGASHIRA, NOBUHARU ; SUZUKI, MAMORU ; TAKEBAYASHI, SYUBUN ; YASHIKI, TAKEO ; CHIKUIE, DAISUKE ; NODA, MASUHIRO ; OKAZAKI, HIDETO ; YOSHIOKA, TATSUO ; NINOMIYA, YUKO ; KIKUYA, YOSHINORI ; KUROKAWA, MICHINORI ; MURAKAMI, YUZURU ; MOGI, GORO ; KURONO, YUICHI ; YUMISAKI, AKITERU ; MORIMITSU, TAMOTSU ; SAKU, KAZUAKI ; HAYASHI, AKITOSHI ; MATSUMOTO, ICHIRO ; KASANO, FUJIHIKO ; OYAMA, MASARU ; FURUTA, SHIGERU ; NOBORI, TAKUO ; FUKAMI, KOZO ; FUKUDA, KATSUNORI ; HIROTA, TSUNEHARU ; MURANO, KENZO ; HASHIMOTO, MAKOTO ; HARAGUCHI, KANEAKI ; OHORI, YASUICHI ; IIDA, FUMIKO ; MATSUNAGA, SHINYA ; HANADA, TAKEHIRO ; DEGUCHI, KOUICHI ; NAKASHIMA, MITSUYOSHI</creatorcontrib><description>In order to objectively evaluate the efficacy and the safety of ceftriaxone (CTRX) using once daily administration of 1g to cases of acute suppurative otitis media and acute exacerbation of chronic suppurative otitis media, a group comparison study by the envelope method was conducted using cefotiam (CTM) as the control drug (2g twice daily). The results obtained are summarized as follows. 1. Clinical efficacies evaluated by the committee were 71% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 63% and 60%, respectively, for chronic suppurative otitis media. When all cases were considered both groups evidenced a clinical efficacy of 64%, and no significant difference was observed between the 2 groups. 2. Clinical efficacies evaluated by the physician in charge were 65% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 72% and 60%, respectively, for chronic suppurative otitis media. When all cases were considered efficacies were, respectively, 70% and 64%, showing no significant difference between the 2 groups. 3. Bacteriological efficacies were 88% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 74% and 62%, respectively, for chronic suppurative otitis media. With all cases bacterial eradication rates were, respectively, 76% and 67%. Bacterial eradication rates were always higher for the CTRX group than for the CTM group, but the difference was not significant between the 2 groups. 4. Against infections caused by Staphylococcus aureus alone, CTRX showed equal clinical and bacteriological efficacies to CTM. 5. As side effects, dermatitis, vomiting, and malaise were observed in 5 cases (4%) of the CTRX group and 3 cases (3%) of the CTM group. As clinical testing abnormalities, elevations of GOT, GPT, and Al-P, and thrombocytopenia were noted only in 3 cases (5%) of the CTRX group. Furthermore, all of these abnormalities were temporary and of moderate degree or mild, thus the safety of either drug was considered high. 6. Clinical utilities were 71% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 72% and 62%, respectively, for chronic suppurative otitis media. When all cases were included, they were 72% and 66%, respectively, and there was no significant difference between the 2 groups. It is concluded from the above results that CTRX is a highly useful drug with once daily administration of 1g in the treatment of suppurative otitis media.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.42.212</identifier><identifier>PMID: 2523493</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacterial Infections - drug therapy ; Bacterial Infections - microbiology ; Cefotiam - administration & dosage ; Cefotiam - adverse effects ; Cefotiam - therapeutic use ; Ceftriaxone - administration & dosage ; Ceftriaxone - adverse effects ; Ceftriaxone - therapeutic use ; Drug Eruptions - etiology ; Drug Evaluation ; Female ; Humans ; Japan ; Male ; Middle Aged ; Multicenter Studies as Topic ; Otitis Media - drug therapy ; Otitis Media, Suppurative - drug therapy ; Otitis Media, Suppurative - microbiology ; Thrombocytopenia - chemically induced ; Vomiting - chemically induced</subject><ispartof>The Japanese Journal of Antibiotics, 1989/01/25, Vol.42(1), pp.212-247</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2523493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BABA, SHUNKICHI</creatorcontrib><creatorcontrib>MORI, YOSHITO</creatorcontrib><creatorcontrib>SUZUKI, KENJI</creatorcontrib><creatorcontrib>UNNO, TOKUJI</creatorcontrib><creatorcontrib>KAWABORI, SHINICHI</creatorcontrib><creatorcontrib>YANAI, TORU</creatorcontrib><creatorcontrib>NONAKA, SATOSHI</creatorcontrib><creatorcontrib>TAKASAKA, TOMONORI</creatorcontrib><creatorcontrib>AWATAGUCHI, TOSHIICHI</creatorcontrib><creatorcontrib>FURUUCHI, ICHIRO</creatorcontrib><creatorcontrib>TANIGAITO, YOSHIYUKI</creatorcontrib><creatorcontrib>GOTOH, HIRONORI</creatorcontrib><creatorcontrib>KIYONO, JIN</creatorcontrib><creatorcontrib>KAWABATA, ISUZU</creatorcontrib><creatorcontrib>KAWAMURA, SHOUZO</creatorcontrib><creatorcontrib>UEHARA, NORIO</creatorcontrib><creatorcontrib>ITABASHI, TAKATSUGU</creatorcontrib><creatorcontrib>FUJIMAKI, YUTAKA</creatorcontrib><creatorcontrib>NOMURA, YASUYA</creatorcontrib><creatorcontrib>MIZUNO, MASAHIRO</creatorcontrib><creatorcontrib>INOUE, NORIFUMI</creatorcontrib><creatorcontrib>SHOUJI, MINORU</creatorcontrib><creatorcontrib>ISHII, TETSUO</creatorcontrib><creatorcontrib>TAKAYAMA, MIKIKO</creatorcontrib><creatorcontrib>MIYAKE, HIROSATO</creatorcontrib><creatorcontrib>SHINKAWA, ATSUSHI</creatorcontrib><creatorcontrib>SAKAI, MAKOTO</creatorcontrib><creatorcontrib>KOMATSU, NOBUYUKI</creatorcontrib><creatorcontrib>MATSUKAWA, JUNICHI</creatorcontrib><creatorcontrib>KAN, SHIMEI</creatorcontrib><creatorcontrib>KIMURA, HIDENARI</creatorcontrib><creatorcontrib>MARUO, TAKESHI</creatorcontrib><creatorcontrib>ITOH, HARUO</creatorcontrib><creatorcontrib>KINOSHITA, HARUJI</creatorcontrib><creatorcontrib>KOBAYASHI, TAKEHIRO</creatorcontrib><creatorcontrib>KAWAI, TAKASHI</creatorcontrib><creatorcontrib>TAKANO, TSUYOSHI</creatorcontrib><creatorcontrib>MATSUNAGA, TORU</creatorcontrib><creatorcontrib>OGINO, HITOSHI</creatorcontrib><creatorcontrib>ASAI, HIDEYO</creatorcontrib><creatorcontrib>SHIRAISHI, TAKAYUKI</creatorcontrib><creatorcontrib>SENBA, OSAMU</creatorcontrib><creatorcontrib>NOTAKE, KEIKO</creatorcontrib><creatorcontrib>TAMAKI, HIROMITSU</creatorcontrib><creatorcontrib>KIMU, SONJIN</creatorcontrib><creatorcontrib>TSUDA, MAMORU</creatorcontrib><creatorcontrib>FURUKAWA, YUTAKA</creatorcontrib><creatorcontrib>TAKEMOTO, ICHIE</creatorcontrib><creatorcontrib>ISHIDA, MINORU</creatorcontrib><creatorcontrib>TAYA, NAOZO</creatorcontrib><creatorcontrib>NOIRI, TERUHISA</creatorcontrib><creatorcontrib>HORI, TETSUJI</creatorcontrib><creatorcontrib>MATSUNAGA, TAKASHI</creatorcontrib><creatorcontrib>TANAKA, OSAMU</creatorcontrib><creatorcontrib>OKASAKA, TOSHIAKI</creatorcontrib><creatorcontrib>YANAGAWA, AKIHISA</creatorcontrib><creatorcontrib>HYOU, YUKIKAZU</creatorcontrib><creatorcontrib>KITAOKU, NORIYUKI</creatorcontrib><creatorcontrib>KITAMURA, HIROYUKI</creatorcontrib><creatorcontrib>NISHIKAWA, ATSUKO</creatorcontrib><creatorcontrib>FUJITA, NOBUYA</creatorcontrib><creatorcontrib>KASHIWAGI, NORIKO</creatorcontrib><creatorcontrib>YANE, KATSUNARI</creatorcontrib><creatorcontrib>HARADA, YASUO</creatorcontrib><creatorcontrib>YAJIN, KOUJI</creatorcontrib><creatorcontrib>TAGASHIRA, NOBUHARU</creatorcontrib><creatorcontrib>SUZUKI, MAMORU</creatorcontrib><creatorcontrib>TAKEBAYASHI, SYUBUN</creatorcontrib><creatorcontrib>YASHIKI, TAKEO</creatorcontrib><creatorcontrib>CHIKUIE, DAISUKE</creatorcontrib><creatorcontrib>NODA, MASUHIRO</creatorcontrib><creatorcontrib>OKAZAKI, HIDETO</creatorcontrib><creatorcontrib>YOSHIOKA, TATSUO</creatorcontrib><creatorcontrib>NINOMIYA, YUKO</creatorcontrib><creatorcontrib>KIKUYA, YOSHINORI</creatorcontrib><creatorcontrib>KUROKAWA, MICHINORI</creatorcontrib><creatorcontrib>MURAKAMI, YUZURU</creatorcontrib><creatorcontrib>MOGI, GORO</creatorcontrib><creatorcontrib>KURONO, YUICHI</creatorcontrib><creatorcontrib>YUMISAKI, AKITERU</creatorcontrib><creatorcontrib>MORIMITSU, TAMOTSU</creatorcontrib><creatorcontrib>SAKU, KAZUAKI</creatorcontrib><creatorcontrib>HAYASHI, AKITOSHI</creatorcontrib><creatorcontrib>MATSUMOTO, ICHIRO</creatorcontrib><creatorcontrib>KASANO, FUJIHIKO</creatorcontrib><creatorcontrib>OYAMA, MASARU</creatorcontrib><creatorcontrib>FURUTA, SHIGERU</creatorcontrib><creatorcontrib>NOBORI, TAKUO</creatorcontrib><creatorcontrib>FUKAMI, KOZO</creatorcontrib><creatorcontrib>FUKUDA, KATSUNORI</creatorcontrib><creatorcontrib>HIROTA, TSUNEHARU</creatorcontrib><creatorcontrib>MURANO, KENZO</creatorcontrib><creatorcontrib>HASHIMOTO, MAKOTO</creatorcontrib><creatorcontrib>HARAGUCHI, KANEAKI</creatorcontrib><creatorcontrib>OHORI, YASUICHI</creatorcontrib><creatorcontrib>IIDA, FUMIKO</creatorcontrib><creatorcontrib>MATSUNAGA, SHINYA</creatorcontrib><creatorcontrib>HANADA, TAKEHIRO</creatorcontrib><creatorcontrib>DEGUCHI, KOUICHI</creatorcontrib><creatorcontrib>NAKASHIMA, MITSUYOSHI</creatorcontrib><title>EVALUATION OF THE EFFICACY OF CEFTRIAXONE IN ACUTE SUPPURATIVE OTITIS MEDIA AND ACUTE EXACERBATION OF CHRONIC SUPPURATIVE OTITIS MEDIA: A COMPARATIVE STUDY WITH CEFOTIAM AS THE CONTROL</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>In order to objectively evaluate the efficacy and the safety of ceftriaxone (CTRX) using once daily administration of 1g to cases of acute suppurative otitis media and acute exacerbation of chronic suppurative otitis media, a group comparison study by the envelope method was conducted using cefotiam (CTM) as the control drug (2g twice daily). The results obtained are summarized as follows. 1. Clinical efficacies evaluated by the committee were 71% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 63% and 60%, respectively, for chronic suppurative otitis media. When all cases were considered both groups evidenced a clinical efficacy of 64%, and no significant difference was observed between the 2 groups. 2. Clinical efficacies evaluated by the physician in charge were 65% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 72% and 60%, respectively, for chronic suppurative otitis media. When all cases were considered efficacies were, respectively, 70% and 64%, showing no significant difference between the 2 groups. 3. Bacteriological efficacies were 88% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 74% and 62%, respectively, for chronic suppurative otitis media. With all cases bacterial eradication rates were, respectively, 76% and 67%. Bacterial eradication rates were always higher for the CTRX group than for the CTM group, but the difference was not significant between the 2 groups. 4. Against infections caused by Staphylococcus aureus alone, CTRX showed equal clinical and bacteriological efficacies to CTM. 5. As side effects, dermatitis, vomiting, and malaise were observed in 5 cases (4%) of the CTRX group and 3 cases (3%) of the CTM group. As clinical testing abnormalities, elevations of GOT, GPT, and Al-P, and thrombocytopenia were noted only in 3 cases (5%) of the CTRX group. Furthermore, all of these abnormalities were temporary and of moderate degree or mild, thus the safety of either drug was considered high. 6. Clinical utilities were 71% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 72% and 62%, respectively, for chronic suppurative otitis media. When all cases were included, they were 72% and 66%, respectively, and there was no significant difference between the 2 groups. It is concluded from the above results that CTRX is a highly useful drug with once daily administration of 1g in the treatment of suppurative otitis media.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - microbiology</subject><subject>Cefotiam - administration & dosage</subject><subject>Cefotiam - adverse effects</subject><subject>Cefotiam - therapeutic use</subject><subject>Ceftriaxone - administration & dosage</subject><subject>Ceftriaxone - adverse effects</subject><subject>Ceftriaxone - therapeutic use</subject><subject>Drug Eruptions - etiology</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multicenter Studies as Topic</subject><subject>Otitis Media - drug therapy</subject><subject>Otitis Media, Suppurative - drug therapy</subject><subject>Otitis Media, Suppurative - microbiology</subject><subject>Thrombocytopenia - chemically induced</subject><subject>Vomiting - chemically induced</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1OwkAUhSdGgwR5BJN5gWLnt9PlOExlDLaktARXzQwtWgJoWlz4Aj63JRAWJm7uzc059-TkAwAif4QQY-TB7g-1qz8O9apFIRduRPEII3wF-hgJ7jEaBNeg7xMuPBwIdAuGbVs7n6BA4C6hB3qYYUJD0gc_eiGnucxMEsMkgtlEQx1FRkn1eryVjrLUyGUSa2hiKFWeaTjPZ7M87X4WGiaZycwcvuixkVDG47NFL6XS6eMlV03SJDbq39c7cLO227YanvcA5JHO1MSbJk9dmam3QdgnXoi72pathAgop9yFJVqVfsARcoxjx0RJKspIaUMaWsTImq390Cclok5whx0ZgPtT7ueX21Vl8dnUO9t8F2cenf580jftwb5VF902HextVfwlX1BcoOPo8F9Mq3fbFNWe_AJGUHXK</recordid><startdate>198901</startdate><enddate>198901</enddate><creator>BABA, SHUNKICHI</creator><creator>MORI, YOSHITO</creator><creator>SUZUKI, KENJI</creator><creator>UNNO, TOKUJI</creator><creator>KAWABORI, SHINICHI</creator><creator>YANAI, TORU</creator><creator>NONAKA, SATOSHI</creator><creator>TAKASAKA, TOMONORI</creator><creator>AWATAGUCHI, TOSHIICHI</creator><creator>FURUUCHI, ICHIRO</creator><creator>TANIGAITO, YOSHIYUKI</creator><creator>GOTOH, HIRONORI</creator><creator>KIYONO, JIN</creator><creator>KAWABATA, ISUZU</creator><creator>KAWAMURA, SHOUZO</creator><creator>UEHARA, NORIO</creator><creator>ITABASHI, TAKATSUGU</creator><creator>FUJIMAKI, YUTAKA</creator><creator>NOMURA, YASUYA</creator><creator>MIZUNO, MASAHIRO</creator><creator>INOUE, NORIFUMI</creator><creator>SHOUJI, MINORU</creator><creator>ISHII, TETSUO</creator><creator>TAKAYAMA, MIKIKO</creator><creator>MIYAKE, HIROSATO</creator><creator>SHINKAWA, ATSUSHI</creator><creator>SAKAI, MAKOTO</creator><creator>KOMATSU, NOBUYUKI</creator><creator>MATSUKAWA, JUNICHI</creator><creator>KAN, SHIMEI</creator><creator>KIMURA, HIDENARI</creator><creator>MARUO, TAKESHI</creator><creator>ITOH, HARUO</creator><creator>KINOSHITA, HARUJI</creator><creator>KOBAYASHI, TAKEHIRO</creator><creator>KAWAI, TAKASHI</creator><creator>TAKANO, TSUYOSHI</creator><creator>MATSUNAGA, TORU</creator><creator>OGINO, HITOSHI</creator><creator>ASAI, HIDEYO</creator><creator>SHIRAISHI, TAKAYUKI</creator><creator>SENBA, OSAMU</creator><creator>NOTAKE, KEIKO</creator><creator>TAMAKI, HIROMITSU</creator><creator>KIMU, SONJIN</creator><creator>TSUDA, MAMORU</creator><creator>FURUKAWA, YUTAKA</creator><creator>TAKEMOTO, ICHIE</creator><creator>ISHIDA, MINORU</creator><creator>TAYA, NAOZO</creator><creator>NOIRI, TERUHISA</creator><creator>HORI, TETSUJI</creator><creator>MATSUNAGA, TAKASHI</creator><creator>TANAKA, OSAMU</creator><creator>OKASAKA, TOSHIAKI</creator><creator>YANAGAWA, AKIHISA</creator><creator>HYOU, YUKIKAZU</creator><creator>KITAOKU, NORIYUKI</creator><creator>KITAMURA, HIROYUKI</creator><creator>NISHIKAWA, ATSUKO</creator><creator>FUJITA, NOBUYA</creator><creator>KASHIWAGI, NORIKO</creator><creator>YANE, KATSUNARI</creator><creator>HARADA, YASUO</creator><creator>YAJIN, KOUJI</creator><creator>TAGASHIRA, NOBUHARU</creator><creator>SUZUKI, MAMORU</creator><creator>TAKEBAYASHI, SYUBUN</creator><creator>YASHIKI, TAKEO</creator><creator>CHIKUIE, DAISUKE</creator><creator>NODA, MASUHIRO</creator><creator>OKAZAKI, HIDETO</creator><creator>YOSHIOKA, TATSUO</creator><creator>NINOMIYA, YUKO</creator><creator>KIKUYA, YOSHINORI</creator><creator>KUROKAWA, MICHINORI</creator><creator>MURAKAMI, YUZURU</creator><creator>MOGI, GORO</creator><creator>KURONO, YUICHI</creator><creator>YUMISAKI, AKITERU</creator><creator>MORIMITSU, TAMOTSU</creator><creator>SAKU, KAZUAKI</creator><creator>HAYASHI, AKITOSHI</creator><creator>MATSUMOTO, ICHIRO</creator><creator>KASANO, FUJIHIKO</creator><creator>OYAMA, MASARU</creator><creator>FURUTA, SHIGERU</creator><creator>NOBORI, TAKUO</creator><creator>FUKAMI, KOZO</creator><creator>FUKUDA, KATSUNORI</creator><creator>HIROTA, TSUNEHARU</creator><creator>MURANO, KENZO</creator><creator>HASHIMOTO, MAKOTO</creator><creator>HARAGUCHI, KANEAKI</creator><creator>OHORI, YASUICHI</creator><creator>IIDA, FUMIKO</creator><creator>MATSUNAGA, SHINYA</creator><creator>HANADA, TAKEHIRO</creator><creator>DEGUCHI, KOUICHI</creator><creator>NAKASHIMA, MITSUYOSHI</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198901</creationdate><title>EVALUATION OF THE EFFICACY OF CEFTRIAXONE IN ACUTE SUPPURATIVE OTITIS MEDIA AND ACUTE EXACERBATION OF CHRONIC SUPPURATIVE OTITIS MEDIA</title><author>BABA, SHUNKICHI ; MORI, YOSHITO ; SUZUKI, KENJI ; UNNO, TOKUJI ; KAWABORI, SHINICHI ; YANAI, TORU ; NONAKA, SATOSHI ; TAKASAKA, TOMONORI ; AWATAGUCHI, TOSHIICHI ; FURUUCHI, ICHIRO ; TANIGAITO, YOSHIYUKI ; GOTOH, HIRONORI ; KIYONO, JIN ; KAWABATA, ISUZU ; KAWAMURA, SHOUZO ; UEHARA, NORIO ; ITABASHI, TAKATSUGU ; FUJIMAKI, YUTAKA ; NOMURA, YASUYA ; MIZUNO, MASAHIRO ; INOUE, NORIFUMI ; SHOUJI, MINORU ; ISHII, TETSUO ; TAKAYAMA, MIKIKO ; MIYAKE, HIROSATO ; SHINKAWA, ATSUSHI ; SAKAI, MAKOTO ; KOMATSU, NOBUYUKI ; MATSUKAWA, JUNICHI ; KAN, SHIMEI ; KIMURA, HIDENARI ; MARUO, TAKESHI ; ITOH, HARUO ; KINOSHITA, HARUJI ; KOBAYASHI, TAKEHIRO ; KAWAI, TAKASHI ; TAKANO, TSUYOSHI ; MATSUNAGA, TORU ; OGINO, HITOSHI ; ASAI, HIDEYO ; SHIRAISHI, TAKAYUKI ; SENBA, OSAMU ; NOTAKE, KEIKO ; TAMAKI, HIROMITSU ; KIMU, SONJIN ; TSUDA, MAMORU ; FURUKAWA, YUTAKA ; TAKEMOTO, ICHIE ; ISHIDA, MINORU ; TAYA, NAOZO ; NOIRI, TERUHISA ; HORI, TETSUJI ; MATSUNAGA, TAKASHI ; TANAKA, OSAMU ; OKASAKA, TOSHIAKI ; YANAGAWA, AKIHISA ; HYOU, YUKIKAZU ; KITAOKU, NORIYUKI ; KITAMURA, HIROYUKI ; NISHIKAWA, ATSUKO ; FUJITA, NOBUYA ; KASHIWAGI, NORIKO ; YANE, KATSUNARI ; HARADA, YASUO ; YAJIN, KOUJI ; TAGASHIRA, NOBUHARU ; SUZUKI, MAMORU ; TAKEBAYASHI, SYUBUN ; YASHIKI, TAKEO ; CHIKUIE, DAISUKE ; NODA, MASUHIRO ; OKAZAKI, HIDETO ; YOSHIOKA, TATSUO ; NINOMIYA, YUKO ; KIKUYA, YOSHINORI ; KUROKAWA, MICHINORI ; MURAKAMI, YUZURU ; MOGI, GORO ; KURONO, YUICHI ; YUMISAKI, AKITERU ; MORIMITSU, TAMOTSU ; SAKU, KAZUAKI ; HAYASHI, AKITOSHI ; MATSUMOTO, ICHIRO ; KASANO, FUJIHIKO ; OYAMA, MASARU ; FURUTA, SHIGERU ; NOBORI, TAKUO ; FUKAMI, KOZO ; FUKUDA, KATSUNORI ; HIROTA, TSUNEHARU ; MURANO, KENZO ; HASHIMOTO, MAKOTO ; HARAGUCHI, KANEAKI ; OHORI, YASUICHI ; IIDA, FUMIKO ; MATSUNAGA, SHINYA ; HANADA, TAKEHIRO ; DEGUCHI, KOUICHI ; NAKASHIMA, MITSUYOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1203-92234a5c8874646b9d1cd07611b562b58d3e453da949a153f5f0903d14b86b2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1989</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - microbiology</topic><topic>Cefotiam - administration & dosage</topic><topic>Cefotiam - adverse effects</topic><topic>Cefotiam - therapeutic use</topic><topic>Ceftriaxone - administration & dosage</topic><topic>Ceftriaxone - adverse effects</topic><topic>Ceftriaxone - therapeutic use</topic><topic>Drug Eruptions - etiology</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multicenter Studies as Topic</topic><topic>Otitis Media - drug therapy</topic><topic>Otitis Media, Suppurative - drug therapy</topic><topic>Otitis Media, Suppurative - microbiology</topic><topic>Thrombocytopenia - chemically induced</topic><topic>Vomiting - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BABA, SHUNKICHI</creatorcontrib><creatorcontrib>MORI, YOSHITO</creatorcontrib><creatorcontrib>SUZUKI, 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(Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BABA, SHUNKICHI</au><au>MORI, YOSHITO</au><au>SUZUKI, KENJI</au><au>UNNO, TOKUJI</au><au>KAWABORI, SHINICHI</au><au>YANAI, TORU</au><au>NONAKA, SATOSHI</au><au>TAKASAKA, TOMONORI</au><au>AWATAGUCHI, TOSHIICHI</au><au>FURUUCHI, ICHIRO</au><au>TANIGAITO, YOSHIYUKI</au><au>GOTOH, HIRONORI</au><au>KIYONO, JIN</au><au>KAWABATA, ISUZU</au><au>KAWAMURA, SHOUZO</au><au>UEHARA, NORIO</au><au>ITABASHI, TAKATSUGU</au><au>FUJIMAKI, YUTAKA</au><au>NOMURA, YASUYA</au><au>MIZUNO, MASAHIRO</au><au>INOUE, NORIFUMI</au><au>SHOUJI, MINORU</au><au>ISHII, TETSUO</au><au>TAKAYAMA, MIKIKO</au><au>MIYAKE, HIROSATO</au><au>SHINKAWA, ATSUSHI</au><au>SAKAI, MAKOTO</au><au>KOMATSU, NOBUYUKI</au><au>MATSUKAWA, JUNICHI</au><au>KAN, SHIMEI</au><au>KIMURA, HIDENARI</au><au>MARUO, TAKESHI</au><au>ITOH, HARUO</au><au>KINOSHITA, HARUJI</au><au>KOBAYASHI, TAKEHIRO</au><au>KAWAI, TAKASHI</au><au>TAKANO, TSUYOSHI</au><au>MATSUNAGA, TORU</au><au>OGINO, HITOSHI</au><au>ASAI, HIDEYO</au><au>SHIRAISHI, TAKAYUKI</au><au>SENBA, OSAMU</au><au>NOTAKE, KEIKO</au><au>TAMAKI, HIROMITSU</au><au>KIMU, SONJIN</au><au>TSUDA, MAMORU</au><au>FURUKAWA, YUTAKA</au><au>TAKEMOTO, ICHIE</au><au>ISHIDA, MINORU</au><au>TAYA, NAOZO</au><au>NOIRI, TERUHISA</au><au>HORI, TETSUJI</au><au>MATSUNAGA, TAKASHI</au><au>TANAKA, OSAMU</au><au>OKASAKA, TOSHIAKI</au><au>YANAGAWA, AKIHISA</au><au>HYOU, YUKIKAZU</au><au>KITAOKU, NORIYUKI</au><au>KITAMURA, HIROYUKI</au><au>NISHIKAWA, ATSUKO</au><au>FUJITA, NOBUYA</au><au>KASHIWAGI, NORIKO</au><au>YANE, KATSUNARI</au><au>HARADA, YASUO</au><au>YAJIN, KOUJI</au><au>TAGASHIRA, NOBUHARU</au><au>SUZUKI, MAMORU</au><au>TAKEBAYASHI, SYUBUN</au><au>YASHIKI, TAKEO</au><au>CHIKUIE, DAISUKE</au><au>NODA, MASUHIRO</au><au>OKAZAKI, HIDETO</au><au>YOSHIOKA, TATSUO</au><au>NINOMIYA, YUKO</au><au>KIKUYA, YOSHINORI</au><au>KUROKAWA, MICHINORI</au><au>MURAKAMI, YUZURU</au><au>MOGI, GORO</au><au>KURONO, YUICHI</au><au>YUMISAKI, AKITERU</au><au>MORIMITSU, TAMOTSU</au><au>SAKU, KAZUAKI</au><au>HAYASHI, AKITOSHI</au><au>MATSUMOTO, ICHIRO</au><au>KASANO, FUJIHIKO</au><au>OYAMA, MASARU</au><au>FURUTA, SHIGERU</au><au>NOBORI, TAKUO</au><au>FUKAMI, KOZO</au><au>FUKUDA, KATSUNORI</au><au>HIROTA, TSUNEHARU</au><au>MURANO, KENZO</au><au>HASHIMOTO, MAKOTO</au><au>HARAGUCHI, KANEAKI</au><au>OHORI, YASUICHI</au><au>IIDA, FUMIKO</au><au>MATSUNAGA, SHINYA</au><au>HANADA, TAKEHIRO</au><au>DEGUCHI, KOUICHI</au><au>NAKASHIMA, MITSUYOSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EVALUATION OF THE EFFICACY OF CEFTRIAXONE IN ACUTE SUPPURATIVE OTITIS MEDIA AND ACUTE EXACERBATION OF CHRONIC SUPPURATIVE OTITIS MEDIA: A COMPARATIVE STUDY WITH CEFOTIAM AS THE CONTROL</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1989-01</date><risdate>1989</risdate><volume>42</volume><issue>1</issue><spage>212</spage><epage>247</epage><pages>212-247</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>In order to objectively evaluate the efficacy and the safety of ceftriaxone (CTRX) using once daily administration of 1g to cases of acute suppurative otitis media and acute exacerbation of chronic suppurative otitis media, a group comparison study by the envelope method was conducted using cefotiam (CTM) as the control drug (2g twice daily). The results obtained are summarized as follows. 1. Clinical efficacies evaluated by the committee were 71% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 63% and 60%, respectively, for chronic suppurative otitis media. When all cases were considered both groups evidenced a clinical efficacy of 64%, and no significant difference was observed between the 2 groups. 2. Clinical efficacies evaluated by the physician in charge were 65% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 72% and 60%, respectively, for chronic suppurative otitis media. When all cases were considered efficacies were, respectively, 70% and 64%, showing no significant difference between the 2 groups. 3. Bacteriological efficacies were 88% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 74% and 62%, respectively, for chronic suppurative otitis media. With all cases bacterial eradication rates were, respectively, 76% and 67%. Bacterial eradication rates were always higher for the CTRX group than for the CTM group, but the difference was not significant between the 2 groups. 4. Against infections caused by Staphylococcus aureus alone, CTRX showed equal clinical and bacteriological efficacies to CTM. 5. As side effects, dermatitis, vomiting, and malaise were observed in 5 cases (4%) of the CTRX group and 3 cases (3%) of the CTM group. As clinical testing abnormalities, elevations of GOT, GPT, and Al-P, and thrombocytopenia were noted only in 3 cases (5%) of the CTRX group. Furthermore, all of these abnormalities were temporary and of moderate degree or mild, thus the safety of either drug was considered high. 6. Clinical utilities were 71% in the CTRX group and 86% in the CTM group for acute suppurative otitis media, and 72% and 62%, respectively, for chronic suppurative otitis media. When all cases were included, they were 72% and 66%, respectively, and there was no significant difference between the 2 groups. It is concluded from the above results that CTRX is a highly useful drug with once daily administration of 1g in the treatment of suppurative otitis media.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>2523493</pmid><doi>10.11553/antibiotics1968b.42.212</doi><tpages>36</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1989/01/25, Vol.42(1), pp.212-247 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
| recordid | cdi_pubmed_primary_2523493 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Bacterial Infections - drug therapy Bacterial Infections - microbiology Cefotiam - administration & dosage Cefotiam - adverse effects Cefotiam - therapeutic use Ceftriaxone - administration & dosage Ceftriaxone - adverse effects Ceftriaxone - therapeutic use Drug Eruptions - etiology Drug Evaluation Female Humans Japan Male Middle Aged Multicenter Studies as Topic Otitis Media - drug therapy Otitis Media, Suppurative - drug therapy Otitis Media, Suppurative - microbiology Thrombocytopenia - chemically induced Vomiting - chemically induced |
| title | EVALUATION OF THE EFFICACY OF CEFTRIAXONE IN ACUTE SUPPURATIVE OTITIS MEDIA AND ACUTE EXACERBATION OF CHRONIC SUPPURATIVE OTITIS MEDIA: A COMPARATIVE STUDY WITH CEFOTIAM AS THE CONTROL |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T00%3A07%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_jstag&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=EVALUATION%20OF%20THE%20EFFICACY%20OF%20CEFTRIAXONE%20IN%20ACUTE%20SUPPURATIVE%20OTITIS%20MEDIA%20AND%20ACUTE%20EXACERBATION%20OF%20CHRONIC%20SUPPURATIVE%20OTITIS%20MEDIA:%20A%20COMPARATIVE%20STUDY%20WITH%20CEFOTIAM%20AS%20THE%20CONTROL&rft.jtitle=Japanese%20journal%20of%20antibiotics&rft.au=BABA,%20SHUNKICHI&rft.date=1989-01&rft.volume=42&rft.issue=1&rft.spage=212&rft.epage=247&rft.pages=212-247&rft.issn=0368-2781&rft.eissn=2186-5477&rft_id=info:doi/10.11553/antibiotics1968b.42.212&rft_dat=%3Cpubmed_jstag%3E2523493%3C/pubmed_jstag%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/2523493&rfr_iscdi=true |