Metabolic stability and inhibitory effect of O-methylated theaflavins on H2O2-induced oxidative damage in human HepG2 cells

Seven new O-methylated theaflavins (TFs) were synthesized by using O-methyltransferase from an edible mushroom. Using TFs and O-methylated TFs, metabolic stability in pooled human liver S9 fractions and inhibitory effect on H 2 O 2 -induced oxidative damage in human HepG2 cells were investigated. In...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2014, Vol.78 (7), p.1140-1146
Hauptverfasser:	Tanaka, Yoshihisa, Kirita, Masanobu, Abe, Yuko, Miyata, Satoshi, Tagashira, Motoyuki, Kanda, Tomomasa, Maeda-Yamamoto, Mari
Format:	Artikel
Sprache:	eng
Schlagworte:	Biflavonoids - chemical synthesis Biflavonoids - chemistry Biflavonoids - metabolism Biflavonoids - pharmacology black tea Catechin - chemical synthesis Catechin - chemistry Catechin - metabolism Catechin - pharmacology Drug Stability Hep G2 Cells Humans Hydrogen Peroxide - pharmacology metabolic stability Methylation O-methylated theaflavin oxidative damage Oxidative Stress - drug effects Oxygen - chemistry polyphenol
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