Hemolysis-induced lethality involves inflammasome activation by heme

The increase of extracellular heme is a hallmark of hemolysis or extensive cell damage. Heme has prooxidant, cytotoxic, and inflammatory effects, playing a central role in the pathogenesis of malaria, sepsis, and sickle cell disease. However, the mechanisms by which heme is sensed by innate immune c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-09, Vol.111 (39), p.E4110-E4118
Hauptverfasser:	Dutra, Fabianno F, Alves, Letícia S, Rodrigues, Danielle, Fernandez, Patricia L, de Oliveira, Rosane B, Golenbock, Douglas T, Zamboni, Dario S, Bozza, Marcelo T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Animals Apoptosis Biological Sciences Carrier Proteins - genetics Carrier Proteins - metabolism Caspase 1 - deficiency Caspase 1 - genetics Caspase 1 - metabolism Cells Cytotoxicity heme Heme - chemistry Heme - immunology Heme - metabolism hemolysis Hemolysis - immunology Hemolysis - physiology Humans immunologic receptors Inflammasomes - immunology Inflammasomes - metabolism inflammation interleukin-1beta Interleukin-1beta - metabolism leucine Macrophage Activation macrophages Macrophages - immunology Macrophages - metabolism malaria Male Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Models, Biological NADPH Oxidase 2 NADPH Oxidases - metabolism NLR Family, Pyrin Domain-Containing 3 Protein Oxygen Pathogenesis PNAS Plus Potassium - metabolism Protoporphyrins - chemistry Protoporphyrins - metabolism Reactive Oxygen Species - metabolism sepsis (infection) sickle cell anemia
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!