Glia selectively approach synapses on thin dendritic spines
This paper examines the relationship between the morphological modality of 189 dendritic spines and the surrounding astroglia using full three-dimensional reconstructions of neuropil fragments. An integrative measure of three-dimensional glial coverage confirms that thin spine postsynaptic densities...
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| Veröffentlicht in: | Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2014-10, Vol.369 (1654), p.20140047-20140047 |
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| container_end_page | 20140047 |
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| container_issue | 1654 |
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| container_title | Philosophical transactions of the Royal Society of London. Series B. Biological sciences |
| container_volume | 369 |
| creator | Medvedev, Nikolai Popov, Victor Henneberger, Christian Kraev, Igor Rusakov, Dmitri A. Stewart, Michael G. |
| description | This paper examines the relationship between the morphological modality of 189 dendritic spines and the surrounding astroglia using full three-dimensional reconstructions of neuropil fragments. An integrative measure of three-dimensional glial coverage confirms that thin spine postsynaptic densities are more tightly surrounded by glia. This distinction suggests that diffusion-dependent synapse–glia communication near ‘learning’ synapses (associated with thin spines) could be stronger than that near ‘memory’ synapses (associated with larger spines). |
| doi_str_mv | 10.1098/rstb.2014.0047 |
| format | Article |
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An integrative measure of three-dimensional glial coverage confirms that thin spine postsynaptic densities are more tightly surrounded by glia. 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| identifier | ISSN: 0962-8436 |
| ispartof | Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2014-10, Vol.369 (1654), p.20140047-20140047 |
| issn | 0962-8436 1471-2970 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central |
| subjects | Animals Dendritic Spines - physiology Glia Protection Image Processing, Computer-Assisted Male Microscopy, Electron Microscopy, Fluorescence Models, Neurological Neuroglia - physiology Neuropil - physiology Patch-Clamp Techniques Rats Rats, Wistar Synapses Synapses - physiology Thin Spines |
| title | Glia selectively approach synapses on thin dendritic spines |
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