Biophysics of protein evolution and evolutionary protein biophysics

The study of molecular evolution at the level of protein-coding genes often entails comparing large datasets of sequences to infer their evolutionary relationships. Despite the importance of a protein's structure and conformational dynamics to its function and thus its fitness, common phylogene...

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Veröffentlicht in:	Journal of the Royal Society interface 2014-11, Vol.11 (100), p.20140419-20140419
Hauptverfasser:	Sikosek, Tobias, Chan, Hue Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Conformational Dynamics Evolution, Molecular Headline Review Hidden States Promiscuous Functions Protein Folding Protein Stability Proteins - chemistry Proteins - genetics Protein–protein Interactions Review Review Articles
Online-Zugang:	Volltext
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