IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcγRIIB-deficient rheumatoid arthritis mouse model

Abstract Objective. We earlier found that TNFα but not interleukin (IL)-17 is indispensable in the pathogenesis of spontaneously occurring rheumatoid arthritis (RA)-like disease in our newly established FcγRIIB-deficient C57BL/6 (B6) mouse model, designated KO1. Here, we examined the role of IL-6 in...

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Veröffentlicht in:	Modern rheumatology 2015-03, Vol.25 (2), p.270-277
Hauptverfasser:	Ohtsuji, Mareki, Lin, Qingshun, Nishikawa, Keiko, Ohtsuji, Naomi, Okazaki, Hideki, Tsurui, Hiromichi, Amano, Hirofumi, Shirai, Toshikazu, Nishimoto, Norihiro, Nishimura, Hiroyuki, Hirose, Sachiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - pathology Autoantibodies - immunology Cytokines - genetics Cytokines - metabolism Disease Models, Animal Interleukin-6 Joints - drug effects Joints - immunology Joints - pathology MCP-1 Mice OPG Osteoclastogenesis Osteoclasts - drug effects Osteoclasts - immunology Osteoclasts - pathology Osteoprotegerin - genetics Osteoprotegerin - metabolism RANK Ligand - genetics RANK Ligand - metabolism RANKL Receptor Activator of Nuclear Factor-kappa B - genetics Receptor Activator of Nuclear Factor-kappa B - metabolism Receptors, IgG - genetics Receptors, IgG - metabolism Receptors, Interleukin-6 - immunology Severity of Illness Index
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