The effect of cores and coating dispersion composition on the mechanical and adhesion properties of hydroxypropyl methylcellulose films
The influence of different additives on the mechanical properties of hydroxypropyl methylcellulose (HPMC) free films was studied using tensile testing. Free films were prepared using the cast method and sliced into bands, and their tensile strength and maximal elongation at break was measured. The r...
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| Veröffentlicht in: | Pharmazie 2014-08, Vol.69 (8), p.595-601 |
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| creator | Banovec, M Planinsek, O Vrecer, F |
| description | The influence of different additives on the mechanical properties of hydroxypropyl methylcellulose (HPMC) free films was studied using tensile testing. Free films were prepared using the cast method and sliced into bands, and their tensile strength and maximal elongation at break was
measured. The results showed that the addition of PEG 400 and polysorbate 80 into the coating formulation had the most influence on the films' mechanical properties compared to the HPMC film used as a control. Tablet cores composed of microcrystalline cellulose and lactose with and without
Mg stearate and compressed at three different compression forces were tested for wettability with coating formulations containing PEG 400 and polysorbate 80. For formulations with no Mg stearate added, the contact angle decreased with increasing core hardness and it also coincided with greater
adhesion force of the coating. The addition of Mg stearate in the core led to reduced adhesion of the film coating with PEG 400, whereas the influence on the adhesion force of the film coating containing polysorbate 80 was negligible. The results also show that the adhesion force, regardless
of the tablet core formulation, is highest at medium core hardness. |
| doi_str_mv | 10.1691/ph.2014.3228 |
| format | Article |
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measured. The results showed that the addition of PEG 400 and polysorbate 80 into the coating formulation had the most influence on the films' mechanical properties compared to the HPMC film used as a control. Tablet cores composed of microcrystalline cellulose and lactose with and without
Mg stearate and compressed at three different compression forces were tested for wettability with coating formulations containing PEG 400 and polysorbate 80. For formulations with no Mg stearate added, the contact angle decreased with increasing core hardness and it also coincided with greater
adhesion force of the coating. The addition of Mg stearate in the core led to reduced adhesion of the film coating with PEG 400, whereas the influence on the adhesion force of the film coating containing polysorbate 80 was negligible. The results also show that the adhesion force, regardless
of the tablet core formulation, is highest at medium core hardness.</description><identifier>ISSN: 0031-7144</identifier><identifier>DOI: 10.1691/ph.2014.3228</identifier><identifier>PMID: 25158570</identifier><language>eng</language><publisher>Germany: Govi-Verlag</publisher><subject>Adhesiveness ; Chemistry, Pharmaceutical ; Excipients - chemistry ; Hardness ; Hypromellose Derivatives ; Methylcellulose - analogs & derivatives ; Methylcellulose - chemistry ; Plasticizers ; Porosity ; Solubility ; Stearic Acids ; Tablets ; Tensile Strength</subject><ispartof>Pharmazie, 2014-08, Vol.69 (8), p.595-601</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>288,314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25158570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banovec, M</creatorcontrib><creatorcontrib>Planinsek, O</creatorcontrib><creatorcontrib>Vrecer, F</creatorcontrib><title>The effect of cores and coating dispersion composition on the mechanical and adhesion properties of hydroxypropyl methylcellulose films</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><addtitle>Pharmazie</addtitle><description>The influence of different additives on the mechanical properties of hydroxypropyl methylcellulose (HPMC) free films was studied using tensile testing. Free films were prepared using the cast method and sliced into bands, and their tensile strength and maximal elongation at break was
measured. The results showed that the addition of PEG 400 and polysorbate 80 into the coating formulation had the most influence on the films' mechanical properties compared to the HPMC film used as a control. Tablet cores composed of microcrystalline cellulose and lactose with and without
Mg stearate and compressed at three different compression forces were tested for wettability with coating formulations containing PEG 400 and polysorbate 80. For formulations with no Mg stearate added, the contact angle decreased with increasing core hardness and it also coincided with greater
adhesion force of the coating. The addition of Mg stearate in the core led to reduced adhesion of the film coating with PEG 400, whereas the influence on the adhesion force of the film coating containing polysorbate 80 was negligible. The results also show that the adhesion force, regardless
of the tablet core formulation, is highest at medium core hardness.</description><subject>Adhesiveness</subject><subject>Chemistry, Pharmaceutical</subject><subject>Excipients - chemistry</subject><subject>Hardness</subject><subject>Hypromellose Derivatives</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Methylcellulose - chemistry</subject><subject>Plasticizers</subject><subject>Porosity</subject><subject>Solubility</subject><subject>Stearic Acids</subject><subject>Tablets</subject><subject>Tensile Strength</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv1DAQhX0A0dJy44xy5LKLHSde54gKtEgVvZSzNWuPN66cONhORfoH-Ns42-2xI0t-Gr33aTRDyEdGt0x07MvUb2vKmi2va_mGnFPK2WbHmuaMvE_pgdJa1EK-I2d1y1rZ7ug5-XffY4XWos5VsJUOEVMFoykKshsPlXFpwphcGEtrmEJyedXl5ZIcUPcwOg3-GALT49E6xVBS2RVYofaLieHvsjYXXzK5X7xG72cfElbW-SFdkrcWfMIPp_-C_P7x_f7qZnN7d_3z6uvtxvGG581OWgOSCoTGtlBKWta2oIU2jRRcCkGBSmj2GsWeS2MaztrOAupWM9Q7fkE-P3PLMH9mTFkNLq2zwIhhTqrQZMsk72ixfjpZ5_2ARk3RDRAX9bK8Yvj1bCh7wjGDeghzHMv0yml1CI9OrQdY968eRTdKVdOaUcm4Yox2yqCF2WeVIarDk0qiAL-9AjzSph7iAE9qPXFBryW6k6BSQczHFv8PChajUw</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Banovec, M</creator><creator>Planinsek, O</creator><creator>Vrecer, F</creator><general>Govi-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>The effect of cores and coating dispersion composition on the mechanical and adhesion properties of hydroxypropyl methylcellulose films</title><author>Banovec, M ; Planinsek, O ; Vrecer, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i343t-78fda806ea4f5aaaa8f155ac6cd48638660a08a4bce6b38dd43159faec5c1ec73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adhesiveness</topic><topic>Chemistry, Pharmaceutical</topic><topic>Excipients - chemistry</topic><topic>Hardness</topic><topic>Hypromellose Derivatives</topic><topic>Methylcellulose - analogs & derivatives</topic><topic>Methylcellulose - chemistry</topic><topic>Plasticizers</topic><topic>Porosity</topic><topic>Solubility</topic><topic>Stearic Acids</topic><topic>Tablets</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banovec, M</creatorcontrib><creatorcontrib>Planinsek, O</creatorcontrib><creatorcontrib>Vrecer, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banovec, M</au><au>Planinsek, O</au><au>Vrecer, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of cores and coating dispersion composition on the mechanical and adhesion properties of hydroxypropyl methylcellulose films</atitle><jtitle>Pharmazie</jtitle><stitle>Pharmazie</stitle><addtitle>Pharmazie</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>69</volume><issue>8</issue><spage>595</spage><epage>601</epage><pages>595-601</pages><issn>0031-7144</issn><abstract>The influence of different additives on the mechanical properties of hydroxypropyl methylcellulose (HPMC) free films was studied using tensile testing. Free films were prepared using the cast method and sliced into bands, and their tensile strength and maximal elongation at break was
measured. The results showed that the addition of PEG 400 and polysorbate 80 into the coating formulation had the most influence on the films' mechanical properties compared to the HPMC film used as a control. Tablet cores composed of microcrystalline cellulose and lactose with and without
Mg stearate and compressed at three different compression forces were tested for wettability with coating formulations containing PEG 400 and polysorbate 80. For formulations with no Mg stearate added, the contact angle decreased with increasing core hardness and it also coincided with greater
adhesion force of the coating. The addition of Mg stearate in the core led to reduced adhesion of the film coating with PEG 400, whereas the influence on the adhesion force of the film coating containing polysorbate 80 was negligible. The results also show that the adhesion force, regardless
of the tablet core formulation, is highest at medium core hardness.</abstract><cop>Germany</cop><pub>Govi-Verlag</pub><pmid>25158570</pmid><doi>10.1691/ph.2014.3228</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pharmazie, 2014-08, Vol.69 (8), p.595-601 |
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| language | eng |
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| source | MEDLINE; IngentaConnect Open Access; EZB Electronic Journals Library |
| subjects | Adhesiveness Chemistry, Pharmaceutical Excipients - chemistry Hardness Hypromellose Derivatives Methylcellulose - analogs & derivatives Methylcellulose - chemistry Plasticizers Porosity Solubility Stearic Acids Tablets Tensile Strength |
| title | The effect of cores and coating dispersion composition on the mechanical and adhesion properties of hydroxypropyl methylcellulose films |
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