The degradation of haem by carbon tetrachloride: Metabolic activation requires a free axial coordination site on the haem iron and electron donation

1. The ability of haem to catalyse the reductive activation of carbon tetrachloride (CCl4) in vitro has been investigated under anaerobic conditions, using methaemalbumin (MHA) and either sodium dithionite or NADPH together with NADPH-cytochrome P-450 reductase (EC 1.6.2.4) as the reducing agents. 2...

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Veröffentlicht in:	Xenobiotica 1989, Vol.19 (9), p.1023-1035
Hauptverfasser:	Manno, M., King, L. J., De Matteis, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carbon Tetrachloride - pharmacology Chemical and industrial products toxicology. Toxic occupational diseases Chemical Phenomena Chemistry Dithionite Hemeproteins - metabolism Medical sciences Methemalbumin - metabolism Microsomes, Liver - metabolism NADPH-Ferrihemoprotein Reductase - metabolism Rats Rats, Inbred Strains Solvents Toxicology
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